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Volumn 13, Issue 6, 2014, Pages 737-749

Immunological aspects of using plant cells as delivery vehicles for oral vaccines

Author keywords

adjuvant; bioencapsulation; glycosylation; low cost vaccine; oral immunogenicity; secondary metabolites

Indexed keywords

ADHESIVE AGENT; ANTIGEN; GLYCAN DERIVATIVE; POLYSACCHARIDE; VACCINE; EDIBLE VACCINE;

EID: 84901029646     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.2014.913483     Document Type: Review
Times cited : (58)

References (98)
  • 1
    • 79953697416 scopus 로고    scopus 로고
    • Clinical development of plant-produced recombinant pharmaceuticals: Vaccines antibodies and beyond
    • Yusibov V, Streatfield SJ, Kushnir N. Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond. Hum Vaccin 2011; 7(3):313-21
    • (2011) Hum Vaccin , vol.7 , Issue.3 , pp. 313-321
    • Yusibov, V.1    Streatfield, S.J.2    Kushnir, N.3
  • 2
    • 84882646501 scopus 로고    scopus 로고
    • Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification
    • Yuki Y, Mejima M, Kurokawa S, et al. Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol J 2013;11(7):799-808
    • (2013) Plant Biotechnol J , vol.11 , Issue.7 , pp. 799-808
    • Yuki, Y.1    Mejima, M.2    Kurokawa, S.3
  • 3
    • 67849130904 scopus 로고    scopus 로고
    • Plant-based oral vaccines: Results of human trials
    • Tacket CO. Plant-based oral vaccines: results of human trials. Curr Top Microbiol Immunol 2009;332:103-17
    • (2009) Curr Top Microbiol Immunol , vol.332 , pp. 103-117
    • Tacket, C.O.1
  • 4
    • 1642563969 scopus 로고    scopus 로고
    • On risk and plant-based biopharmaceuticals
    • Peterson RK, Arntzen CJ. On risk and plant-based biopharmaceuticals. Trends Biotechnol 2004;22(2):64-6
    • (2004) Trends Biotechnol , vol.22 , Issue.2 , pp. 64-66
    • Peterson, R.K.1    Arntzen, C.J.2
  • 5
    • 84881341607 scopus 로고    scopus 로고
    • Subcellular accumulation and modification of pharmaceutical proteins in different plant tissues
    • Hofbauer A, Stoger E. Subcellular accumulation and modification of pharmaceutical proteins in different plant tissues. Curr Pharm Des 2013;19(31): 5495-502
    • (2013) Curr Pharm des , vol.19 , Issue.31 , pp. 5495-5502
    • Hofbauer, A.1    Stoger, E.2
  • 6
    • 84877999567 scopus 로고    scopus 로고
    • Green factories for biopharmaceuticals
    • Melnik S, Stoger E. Green factories for biopharmaceuticals. Curr Med Chem 2013; 20(8):1038-46
    • (2013) Curr Med Chem , vol.20 , Issue.8 , pp. 1038-1046
    • Melnik, S.1    Stoger, E.2
  • 8
    • 0029841664 scopus 로고    scopus 로고
    • M cells in Peyer's patches of the intestine
    • Gebert A, Rothkotter HJ, Pabst R. M cells in Peyer's patches of the intestine. Int Rev Cytol 1996;167:91-159
    • (1996) Int Rev Cytol , vol.167 , pp. 91-159
    • Gebert, A.1    Rothkotter, H.J.2    Pabst, R.3
  • 9
    • 0030576516 scopus 로고    scopus 로고
    • Epithelial M cells, gateways for mucosal infection and immunization
    • Neutra MR, Frey A, Kraehenbuhl JP. Epithelial M cells, gateways for mucosal infection and immunization. Cell 1996; 86(3):345-8
    • (1996) Cell , vol.86 , Issue.3 , pp. 345-348
    • Neutra, M.R.1    Frey, A.2    Kraehenbuhl, J.P.3
  • 10
    • 77955278520 scopus 로고    scopus 로고
    • Enemy at the gates: Dendritic cells and immunity to mucosal pathogens
    • Soloff AC, Barratt-Boyes SM. Enemy at the gates: dendritic cells and immunity to mucosal pathogens. Cell Res 2010;20(8): 872-85
    • (2010) Cell Res , vol.20 , Issue.8 , pp. 872-885
    • Soloff, A.C.1    Barratt-Boyes, S.M.2
  • 11
    • 33846844985 scopus 로고    scopus 로고
    • Generation of gut-homing T cells and their localization to the small intestinal mucosa
    • Johansson-Lindbom B, Agace WW. Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunol Rev 2007;215:226-42
    • (2007) Immunol Rev , vol.215 , pp. 226-242
    • Johansson-Lindbom, B.1    Agace, W.W.2
  • 12
    • 33947491839 scopus 로고    scopus 로고
    • Gut lymphocyte migration, we are halfway 'home'
    • McGhee JR, Kunisawa J, Kiyono H. Gut lymphocyte migration, we are halfway 'home'. Trends Immunol 2007;28(4):150-3
    • (2007) Trends Immunol , vol.28 , Issue.4 , pp. 150-153
    • McGhee, J.R.1    Kunisawa, J.2    Kiyono, H.3
  • 13
    • 33751223544 scopus 로고    scopus 로고
    • Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    • Mora JR, Iwata M, Eksteen B, et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 2006;314(5802):1157-60
    • (2006) Science , vol.314 , Issue.5802 , pp. 1157-1160
    • Mora, J.R.1    Iwata, M.2    Eksteen, B.3
  • 14
    • 34249710939 scopus 로고    scopus 로고
    • Induction of organ-selective CD4+ regulatory T cell homing
    • Siewert C, Menning A, Dudda J, et al. Induction of organ-selective CD4+ regulatory T cell homing. Eur J Immunol 2007;37(4):978-89
    • (2007) Eur J Immunol , vol.37 , Issue.4 , pp. 978-989
    • Siewert, C.1    Menning, A.2    Dudda, J.3
  • 16
    • 0037391351 scopus 로고    scopus 로고
    • Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties
    • Bilsborough J, George TC, Norment A, Viney JL. Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties. Immunology 2003;108(4):481-92
    • (2003) Immunology , vol.108 , Issue.4 , pp. 481-492
    • Bilsborough, J.1    George, T.C.2    Norment, A.3    Viney, J.L.4
  • 17
    • 33645054315 scopus 로고    scopus 로고
    • Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells
    • Worbs T, Bode U, Yan S, et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 2006;203(3): 519-27
    • (2006) J Exp Med , vol.203 , Issue.3 , pp. 519-527
    • Worbs, T.1    Bode, U.2    Yan, S.3
  • 18
    • 48449103933 scopus 로고    scopus 로고
    • Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration
    • Guetard D, Greco R, Cervantes Gonzalez M, et al. Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration. Vaccine 2008;26(35): 4477-85
    • (2008) Vaccine , vol.26 , Issue.35 , pp. 4477-4485
    • Guetard, D.1    Greco, R.2    Cervantes Gonzalez, M.3
  • 19
    • 0031762753 scopus 로고    scopus 로고
    • A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes
    • Arakawa T, Yu J, Chong DK, et al. A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes. Nat Biotechnol 1998;16(10):934-8
    • (1998) Nat Biotechnol , vol.16 , Issue.10 , pp. 934-938
    • Arakawa, T.1    Yu, J.2    Chong, D.K.3
  • 20
    • 77649232515 scopus 로고    scopus 로고
    • Expression of a ricin toxin B subunit: Insulin fusion protein in edible plant tissues
    • Carter JE, Odumosu O, Langridge WHR. Expression of a ricin toxin B subunit: insulin fusion protein in edible plant tissues. Mol Biotechnol 2010;44(2):90-100
    • (2010) Mol Biotechnol , vol.44 , Issue.2 , pp. 90-100
    • Carter, J.E.1    Odumosu, O.2    Langridge, W.H.R.3
  • 21
    • 84876318983 scopus 로고    scopus 로고
    • Production of a chimeric allergen derived from the major allergen group 1 of house dust mite species in Nicotiana benthamiana
    • Li C, Jiang Y, Guo W, Liu Z. Production of a chimeric allergen derived from the major allergen group 1 of house dust mite species in Nicotiana benthamiana. Hum Immunol 2013;74(5):531-7
    • (2013) Hum Immunol , vol.74 , Issue.5 , pp. 531-537
    • Li, C.1    Jiang, Y.2    Guo, W.3    Liu, Z.4
  • 22
    • 80052516050 scopus 로고    scopus 로고
    • Construction of a der p2-transgenic plant for the alleviation of airway inflammation
    • Lee CC, Ho H, Lee KT, et al. Construction of a Der p2-transgenic plant for the alleviation of airway inflammation. Cell Mol Immunol 2011;8(5):404-14
    • (2011) Cell Mol Immunol , vol.8 , Issue.5 , pp. 404-414
    • Lee, C.C.1    Ho, H.2    Lee, K.T.3
  • 23
    • 33846588530 scopus 로고    scopus 로고
    • A rice-based edible vaccine expressing multiple T-cell epitopes to induce oral tolerance and inhibit allergy
    • Takaiwa F. A rice-based edible vaccine expressing multiple T-cell epitopes to induce oral tolerance and inhibit allergy. Immunol Allergy Clin North Am 2007;27(1):129-39
    • (2007) Immunol Allergy Clin North Am , vol.27 , Issue.1 , pp. 129-139
    • Takaiwa, F.1
  • 24
    • 84871687702 scopus 로고    scopus 로고
    • Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollinosis
    • Wakasa Y, Takagi H, Hirose S, et al. Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollinosis. Plant Biotechnol J 2013;11(1): 66-76
    • (2013) Plant Biotechnol J , vol.11 , Issue.1 , pp. 66-76
    • Wakasa, Y.1    Takagi, H.2    Hirose, S.3
  • 25
    • 84869468695 scopus 로고    scopus 로고
    • Optimizing efficacy of mucosal vaccines
    • Gebril A, Alsaadi M, Acevedo R, et al. Optimizing efficacy of mucosal vaccines. Expert Rev Vaccines 2012;11(9):1139-55
    • (2012) Expert Rev Vaccines , vol.11 , Issue.9 , pp. 1139-1155
    • Gebril, A.1    Alsaadi, M.2    Acevedo, R.3
  • 27
    • 33744523262 scopus 로고    scopus 로고
    • Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines
    • Ernst WA, Kim HJ, Tumpey TM, et al. Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines. Vaccine 2006; 24(24):5158-68
    • (2006) Vaccine , vol.24 , Issue.24 , pp. 5158-5168
    • Ernst, W.A.1    Kim, H.J.2    Tumpey, T.M.3
  • 28
    • 9644281079 scopus 로고    scopus 로고
    • Protection against influenza virus infection by intranasal administration of hemagglutinin vaccine with chitin microparticles as an adjuvant
    • Hasegawa H, Ichinohe T, Strong P, et al. Protection against influenza virus infection by intranasal administration of hemagglutinin vaccine with chitin microparticles as an adjuvant. J Med Virol 2005;75(1):130-6
    • (2005) J Med Virol , vol.75 , Issue.1 , pp. 130-136
    • Hasegawa, H.1    Ichinohe, T.2    Strong, P.3
  • 29
    • 33750728433 scopus 로고    scopus 로고
    • Targeting dendritic cells with biomaterials, developing the next generation of vaccines
    • Reddy ST, Swartz MA, Hubbell JA. Targeting dendritic cells with biomaterials, developing the next generation of vaccines. Trends Immunol 2006;27(12):573-9
    • (2006) Trends Immunol , vol.27 , Issue.12 , pp. 573-579
    • Reddy, S.T.1    Swartz, M.A.2    Hubbell, J.A.3
  • 30
    • 62849109927 scopus 로고    scopus 로고
    • Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems
    • Sharma S, Mukkur TK, Benson HA, Chen Y. Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems. J Pharm Sci 2009;98(3):812-43
    • (2009) J Pharm Sci , vol.98 , Issue.3 , pp. 812-843
    • Sharma, S.1    Mukkur, T.K.2    Benson, H.A.3    Chen, Y.4
  • 31
    • 0026473039 scopus 로고
    • Immunologic aspects of liposomes: Presentation and processing of liposomal proteinand phospholipid antigens
    • Alving CR. Immunologic aspects of liposomes: presentation and processing of liposomal proteinand phospholipid antigens. Biochim Biophys Acta 1992;1113(3-4): 307-22
    • (1992) Biochim Biophys Acta , vol.1113 , Issue.3-4 , pp. 307-322
    • Alving, C.R.1
  • 32
    • 23644456486 scopus 로고    scopus 로고
    • Drug delivery systems using immobilized intact liposomes: A comparative and critical review
    • Brochu H, Polidori A, Pucci B, Vermette P. Drug delivery systems using immobilized intact liposomes: a comparative and critical review. Curr Drug Deliv 2004;1(3):299-312
    • (2004) Curr Drug Deliv , vol.1 , Issue.3 , pp. 299-312
    • Brochu, H.1    Polidori, A.2    Pucci, B.3    Vermette, P.4
  • 33
    • 0025129271 scopus 로고
    • Immunological adjuvants: A role for liposomes
    • Gregoriadis G. Immunological adjuvants: a role for liposomes. Immunol Today 1990; 11(3):89-97
    • (1990) Immunol Today , vol.11 , Issue.3 , pp. 89-97
    • Gregoriadis, G.1
  • 34
    • 84859085735 scopus 로고    scopus 로고
    • Novel vaccine development strategies for inducing mucosal immunity
    • Fujkuyama Y, Tokuhara D, Kataoka K, et al. Novel vaccine development strategies for inducing mucosal immunity. Expert Rev Vaccines 2012;11(3):367-79
    • (2012) Expert Rev Vaccines , vol.11 , Issue.3 , pp. 367-379
    • Fujkuyama, Y.1    Tokuhara, D.2    Kataoka, K.3
  • 35
    • 33644527920 scopus 로고    scopus 로고
    • Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice
    • Alvarez ML, Pinyerd HL, Crisantes JD, et al. Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine 2006; 24(14):2477-90
    • (2006) Vaccine , vol.24 , Issue.14 , pp. 2477-2490
    • Alvarez, M.L.1    Pinyerd, H.L.2    Crisantes, J.D.3
  • 36
    • 80054063943 scopus 로고    scopus 로고
    • The release and induced immune responses of a plant-made and delivered antigen in the mouse gut
    • Pelosi A, Shepherd R, Guzman GD, et al. The release and induced immune responses of a plant-made and delivered antigen in the mouse gut. Curr Drug Deliv 2011;8(6): 612-21
    • (2011) Curr Drug Deliv , vol.8 , Issue.6 , pp. 612-621
    • Pelosi, A.1    Shepherd, R.2    Guzman, G.D.3
  • 37
    • 81155131098 scopus 로고    scopus 로고
    • Hairy roots cultures from different Solanaceous species have varying capacities to produce E. Coli B-subunit heat-labile toxin antigen
    • De Guzman G, Walmsley AM, Webster DE, Hamill JD. Hairy roots cultures from different Solanaceous species have varying capacities to produce E. coli B-subunit heat-labile toxin antigen. Biotechnol Lett 2011;33(12):2495-502
    • (2011) Biotechnol Lett , vol.33 , Issue.12 , pp. 2495-2502
    • De Guzman, G.1    Walmsley, A.M.2    Webster, D.E.3    Hamill, J.D.4
  • 38
    • 84871447353 scopus 로고    scopus 로고
    • The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep
    • Pelosi A, Piedrafita D, De Guzman G, et al. The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep. PLoS One 2012;7(12):e52907
    • (2012) PLoS One , vol.7 , Issue.12
    • Pelosi, A.1    Piedrafita, D.2    De Guzman, G.3
  • 39
    • 79955941041 scopus 로고    scopus 로고
    • Immunogenicity of nuclear-encoded LTB:ST fusion protein from Escherichia coli expressed in tobacco plants
    • Rosales-Mendoza S, Soria-Guerra RE, Moreno-Fierros L, et al. Immunogenicity of nuclear-encoded LTB:ST fusion protein from Escherichia coli expressed in tobacco plants. Plant Cell Rep 2011;30(6):1145-52
    • (2011) Plant Cell Rep , vol.30 , Issue.6 , pp. 1145-1152
    • Rosales-Mendoza, S.1    Soria-Guerra, R.E.2    Moreno-Fierros, L.3
  • 40
    • 67650232931 scopus 로고    scopus 로고
    • Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells
    • Kostrzak A, Cervantes Gonzalez M, Guetard D, et al. Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells. Vaccine 2009;27(35):4798-807
    • (2009) Vaccine , vol.27 , Issue.35 , pp. 4798-4807
    • Kostrzak, A.1    Cervantes Gonzalez, M.2    Guetard, D.3
  • 41
    • 79955917510 scopus 로고    scopus 로고
    • Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation
    • Pniewski T, Kapusta J, Bociag P, et al. Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation. J Appl Genet 2011;52(2): 125-36
    • (2011) J Appl Genet , vol.52 , Issue.2 , pp. 125-136
    • Pniewski, T.1    Kapusta, J.2    Bociag, P.3
  • 42
    • 84874945035 scopus 로고    scopus 로고
    • Approaches for enhancing oral bioavailability of peptides and proteins
    • Renukuntla J, Vadlapudi AD, Patel A, et al. Approaches for enhancing oral bioavailability of peptides and proteins. Int J Pharm 2013;447(1-2):75-93
    • (2013) Int J Pharm , vol.447 , Issue.1-2 , pp. 75-93
    • Renukuntla, J.1    Vadlapudi, A.D.2    Patel, A.3
  • 43
    • 84866046099 scopus 로고    scopus 로고
    • Using storage organelles for the accumulation and encapsulation of recombinant proteins
    • Khan I, Twyman RM, Arcalis E, Stoger E. Using storage organelles for the accumulation and encapsulation of recombinant proteins. Biotechnol J 2012; 7(9):1099-108
    • (2012) Biotechnol J , vol.7 , Issue.9 , pp. 1099-1108
    • Khan, I.1    Twyman, R.M.2    Arcalis, E.3    Stoger, E.4
  • 44
    • 0035949504 scopus 로고    scopus 로고
    • Oral immunization with hepatitis B surface antigen expressed in transgenic plants
    • Kong Q, Richter L, Yang YF, et al. Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proc Natl Acad Sci USA 2001;98(20):11539-44
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.20 , pp. 11539-11544
    • Kong, Q.1    Richter, L.2    Yang, Y.F.3
  • 45
    • 41349093562 scopus 로고    scopus 로고
    • Plant cell wall breakdown by anaerobic microorganisms from the Mammalian digestive tract
    • Flint HJ, Bayer EA. Plant cell wall breakdown by anaerobic microorganisms from the Mammalian digestive tract. Ann N YAcad Sci 2008;1125:280-8
    • (2008) Ann N YAcad Sci , vol.1125 , pp. 280-288
    • Flint, H.J.1    Bayer, E.A.2
  • 46
    • 84883241122 scopus 로고    scopus 로고
    • Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins
    • Arcalis E, Stadlmann J, Rademacher T, et al. Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins. Plant Mol Biol 2013;83(1-2):105-17
    • (2013) Plant Mol Biol , vol.83 , Issue.1-2 , pp. 105-117
    • Arcalis, E.1    Stadlmann, J.2    Rademacher, T.3
  • 47
    • 0031763227 scopus 로고    scopus 로고
    • Physical and chemical transformations of cereal food during oral digestion in human subjects
    • Hoebler C, Karinthi A, Devaux M-F, et al. Physical and chemical transformations of cereal food during oral digestion in human subjects. Br J Nutr 1998;80(5):429-36
    • (1998) Br J Nutr , vol.80 , Issue.5 , pp. 429-436
    • Hoebler, C.1    Karinthi, A.2    Devaux, M.-F.3
  • 48
    • 0038822095 scopus 로고    scopus 로고
    • Chemistry architecture and composition of dietary fiber from plant cell walls
    • Cho SS Dreher ML editors, Marcel Dekker Inc; New York, USA
    • MacDougall AJ, Selvedran RR. Chemistry, architecture, and composition of dietary fiber from plant cell walls. In: Cho SS, Dreher ML, editors. Handbook of dietary fiber. Marcel Dekker Inc; New York, USA: 2001. p. 281-319
    • (2001) Handbook of Dietary Fiber , pp. 281-319
    • Macdougall, A.J.1    Selvedran, R.R.2
  • 49
    • 33644570289 scopus 로고    scopus 로고
    • Carotenoids: Factors affecting bioavailability
    • Pfannhuaser W, Fenwick GR, Khokhar S, editors. Analysis, metabolism, bioavailability and function. The Royal Society of Chemistry; Cambridge, UK
    • van den Berg H. Carotenoids: factors affecting bioavailability. In Biologically-active phytochemicals in food. In: Pfannhuaser W, Fenwick GR, Khokhar S, editors. Analysis, metabolism, bioavailability and function. The Royal Society of Chemistry; Cambridge, UK 2001. p. 407-15
    • (2001) Biologically-active Phytochemicals in Food , pp. 407-415
    • Van Den Berg, H.1
  • 50
    • 0001831698 scopus 로고
    • Relationship between microstructure and in vitro digestibility of starch in precooked leguminous seed flours
    • Tovar J, Defrancisco A, Bjorck I, Asp NG. Relationship between microstructure and in vitro digestibility of starch in precooked leguminous seed flours. Food Structure 1991;10(1):19-26
    • (1991) Food Structure , vol.10 , Issue.1 , pp. 19-26
    • Tovar, J.1    Defrancisco, A.2    Bjorck, I.3    Asp, N.G.4
  • 51
    • 0035895726 scopus 로고    scopus 로고
    • An investigation of the action of porcine pancreatic a-amylase on native and gelatinised starches
    • Slaughter SL, Ellis PR, Butterworth PJ. An investigation of the action of porcine pancreatic a-amylase on native and gelatinised starches. Biochim Biophys Acta 2001;1525(1-2):29-36
    • (2001) Biochim Biophys Acta , vol.1525 , Issue.1-2 , pp. 29-36
    • Slaughter, S.L.1    Ellis, P.R.2    Butterworth, P.J.3
  • 52
    • 78650399829 scopus 로고    scopus 로고
    • Particle size reduction leading to cell wall rupture is more important for the b-carotene bioaccessibility of raw compared to thermally processed carrots
    • Lemmens L, Van Buggenhout S, Van Loey AM, Hendrickx ME. Particle size reduction leading to cell wall rupture is more important for the b-carotene bioaccessibility of raw compared to thermally processed carrots. J Agric Food Chem 2010;58(24):12769-76
    • (2010) J Agric Food Chem , vol.58 , Issue.24 , pp. 12769-12776
    • Lemmens, L.1    Van Buggenhout, S.2    Van Loey, A.M.3    Hendrickx, M.E.4
  • 53
    • 79952103981 scopus 로고    scopus 로고
    • Plant-derived medicines: A novel class of immunological adjuvants
    • Licciardi PV, Underwood JR. Plant-derived medicines: a novel class of immunological adjuvants. Int Immunopharmacol 2011; 11(3):390-8
    • (2011) Int Immunopharmacol , vol.11 , Issue.3 , pp. 390-398
    • Licciardi, P.V.1    Underwood, J.R.2
  • 54
    • 0037150480 scopus 로고    scopus 로고
    • Activation of antigen presenting cells by immunostimulatory plant DNA: A natural resource for potential adjuvant
    • Wang Y, Wang W, Li N, et al. Activation of antigen presenting cells by immunostimulatory plant DNA: a natural resource for potential adjuvant. Vaccine 2002;20(21-22):2764-71
    • (2002) Vaccine , vol.20 , Issue.21-22 , pp. 2764-2771
    • Wang, Y.1    Wang, W.2    Li, N.3
  • 55
    • 61349084783 scopus 로고    scopus 로고
    • Advances in saponin-based adjuvants
    • Sun HX, Xie Y, Ye YP. Advances in saponin-based adjuvants. Vaccine 2009; 27(12):1787-96
    • (2009) Vaccine , vol.27 , Issue.12 , pp. 1787-1796
    • Sun, H.X.1    Xie, Y.2    Ye, Y.P.3
  • 56
    • 77955244744 scopus 로고    scopus 로고
    • In planta production of plant-derived and non-plant-derived adjuvants
    • Granell A, Fernandez del-Carmen A, Orzaez D. In planta production of plant-derived and non-plant-derived adjuvants. Expert Rev Vaccines 2010;9(8): 843-58
    • (2010) Expert Rev Vaccines , vol.9 , Issue.8 , pp. 843-858
    • Granell, A.1    Fernandez Del-Carmen, A.2    Orzaez, D.3
  • 57
    • 0034769777 scopus 로고    scopus 로고
    • Inhibition of cellular immune responses by Tylophora indica in experimental models
    • Ganguly T, Sainis KB. Inhibition of cellular immune responses by Tylophora indica in experimental models. Phytomedicine 2001;8:348-55
    • (2001) Phytomedicine , vol.8 , pp. 348-355
    • Ganguly, T.1    Sainis, K.B.2
  • 58
    • 84936992297 scopus 로고    scopus 로고
    • Lectins are specific carbohydrate-binding proteins
    • W H Freeman; NY, USA, Section 11.4
    • Berg JM, Tymoczko JL, Stryer L. Lectins are specific carbohydrate-binding proteins. In: Biochemistry. 5th edition). W H Freeman; NY, USA: 2002; Section 11.4
    • (2002) Biochemistry. 5th Edition
    • Berg, J.M.1    Tymoczko, J.L.2    Stryer, L.3
  • 59
    • 0036413257 scopus 로고    scopus 로고
    • Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2
    • Lavelle EC, Grant G, Pusztai A, et al. Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2. Immunology 2002; 107(2):268-74
    • (2002) Immunology , vol.107 , Issue.2 , pp. 268-274
    • Lavelle, E.C.1    Grant, G.2    Pusztai, A.3
  • 60
    • 27744548806 scopus 로고    scopus 로고
    • Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex europaeus-I lectin as M cell target
    • Manocha M, Pal PC, Chitralekha KT, et al. Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex europaeus-I lectin as M cell target. Vaccine 2005;23(48-49):5599-617
    • (2005) Vaccine , vol.23 , Issue.48-49 , pp. 5599-5617
    • Manocha, M.1    Pal, P.C.2    Chitralekha, K.T.3
  • 61
    • 44849086240 scopus 로고    scopus 로고
    • Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed
    • Huang L, Ikejiri A, Shimizu Y, et al. Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed. J Vet Med Sci 2008;70(5):533-5
    • (2008) J Vet Med Sci , vol.70 , Issue.5 , pp. 533-535
    • Huang, L.1    Ikejiri, A.2    Shimizu, Y.3
  • 62
    • 0029995975 scopus 로고    scopus 로고
    • Lectin binding reveals divergent carbohydrate expression in human and mouse Peyer's patches
    • Sharma R, van Damme EJM, Peumans WJ, et al. Lectin binding reveals divergent carbohydrate expression in human and mouse Peyer's patches. Histochem Cell Biol 1996;105:459-65
    • (1996) Histochem Cell Biol , vol.105 , pp. 459-465
    • Sharma, R.1    Van Damme Ejm2    Peumans, W.J.3
  • 63
    • 31044440131 scopus 로고    scopus 로고
    • Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential
    • Schepetkin IA, Quinn MT. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential. Int Immunopharmacol 2006;6(3): 317-33
    • (2006) Int Immunopharmacol , vol.6 , Issue.3 , pp. 317-333
    • Schepetkin, I.A.1    Quinn, M.T.2
  • 64
    • 57349121025 scopus 로고    scopus 로고
    • Chemical properties and adjuvant activity of a galactoglucomannan from Acrocomia aculeata
    • da Silva BP, de Medeiros Silva G, Parente JP. Chemical properties and adjuvant activity of a galactoglucomannan from Acrocomia aculeata. Carbohydr Polym 2009;75(3):380-4
    • (2009) Carbohydr Polym , vol.75 , Issue.3 , pp. 380-384
    • Da Silva, B.P.1    De Medeiros Silva, G.2    Parente, J.P.3
  • 65
    • 77952717965 scopus 로고    scopus 로고
    • An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses
    • Lobigs M, Pavy M, Hall RA, et al. An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. J Gen Virol 2010;91(6):1407-17
    • (2010) J Gen Virol , vol.91 , Issue.6 , pp. 1407-1417
    • Lobigs, M.1    Pavy, M.2    Hall, R.A.3
  • 66
    • 33645218007 scopus 로고    scopus 로고
    • Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity
    • Petrovsky N. Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Vaccine 2006; 24(Suppl 2):S2-26-9
    • (2006) Vaccine , vol.24 , Issue.SUPPL. 2
    • Petrovsky, N.1
  • 67
    • 3142642822 scopus 로고    scopus 로고
    • Starch microparticles as an adjuvant in immunisation: Effect of route of administration on the immune response in mice
    • Stertman L, Strindelius L, Sjöholm I. Starch microparticles as an adjuvant in immunisation: effect of route of administration on the immune response in mice. Vaccine 2004;22(21-22):2863-72
    • (2004) Vaccine , vol.22 , Issue.21-22 , pp. 2863-2872
    • Stertman, L.1    Strindelius, L.2    Sjöholm, I.3
  • 68
    • 33744780712 scopus 로고    scopus 로고
    • Characterisation of the oral adjuvant effect of lemnan, a pectic polysaccharide of Lemna minor L
    • Popov SV, Golovchenko VV, Ovodova RG, et al. Characterisation of the oral adjuvant effect of lemnan, a pectic polysaccharide of Lemna minor L. Vaccine 2006;24:5413-19
    • (2006) Vaccine , vol.24 , pp. 5413-5419
    • Popov, S.V.1    Golovchenko, V.V.2    Ovodova, R.G.3
  • 69
    • 4344587843 scopus 로고    scopus 로고
    • Biological activities and distribution of plant saponins
    • Sparg SG, Light ME, van Staden J. Biological activities and. distribution of plant saponins. J Ethnopharmacol 2004; 94(2-3):219-43
    • (2004) J Ethnopharmacol , vol.94 , Issue.2-3 , pp. 219-243
    • Sparg, S.G.1    Light, M.E.2    Van Staden, J.3
  • 70
    • 0026443146 scopus 로고
    • The control of the antibody isotype response to recombinant immunodeficiency virus gp120 antigen by adjuvants
    • Bomford R, Stapleton M, Winsor S, et al. The control of the antibody isotype response to recombinant immunodeficiency virus gp120 antigen by adjuvants. AIDS Res Hum Retroviruses 1992;8(10):1765-71
    • (1992) AIDS Res Hum Retroviruses , vol.8 , Issue.10 , pp. 1765-1771
    • Bomford, R.1    Stapleton, M.2    Winsor, S.3
  • 71
    • 0033588527 scopus 로고    scopus 로고
    • Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice
    • Moreno CA, Rodriguez R, Oliveira GA, et al. Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice. Vaccine 1999;18(1-2):89-99
    • (1999) Vaccine , vol.18 , Issue.1-2 , pp. 89-99
    • Moreno, C.A.1    Rodriguez, R.2    Oliveira, G.A.3
  • 72
    • 0035898945 scopus 로고    scopus 로고
    • Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21
    • Waite DC, Jacobson EW, Ennis FA, et al. Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. Vaccine 2001;19(28-29): 3957-67
    • (2001) Vaccine , vol.19 , Issue.28-29 , pp. 3957-3967
    • Waite, D.C.1    Jacobson, E.W.2    Ennis, F.A.3
  • 73
    • 28644442516 scopus 로고    scopus 로고
    • Crude saponins improve the immune response to an oral plant-made measles vaccine
    • Pickering RJ, Smith SD, Strugnell RA, et al. Crude saponins improve the immune response to an oral plant-made measles vaccine. Vaccine 2006;24(2):144-50
    • (2006) Vaccine , vol.24 , Issue.2 , pp. 144-150
    • Pickering, R.J.1    Smith, S.D.2    Strugnell, R.A.3
  • 74
    • 34247384648 scopus 로고    scopus 로고
    • A new highly effective anticysticercosis vaccine expressed in transgenic papaya
    • Hernandez M, Cabrera-Ponce JL, Fragoso G, et al. A new highly effective anticysticercosis vaccine expressed in transgenic papaya. Vaccine 2007;25(21): 4252-60
    • (2007) Vaccine , vol.25 , Issue.21 , pp. 4252-4260
    • Hernandez, M.1    Cabrera-Ponce, J.L.2    Fragoso, G.3
  • 75
    • 33748560122 scopus 로고    scopus 로고
    • Phyto-saponins as a natural adjuvant for delivery of agromaterials through plant cuticle membranes
    • Chapagain BP, Wiesman Z. Phyto-saponins as a natural adjuvant for delivery of agromaterials through plant cuticle membranes. J Agric Food Chem 2006;54: 6277-85
    • (2006) J Agric Food Chem , vol.54 , pp. 6277-6285
    • Chapagain, B.P.1    Wiesman, Z.2
  • 76
    • 76149088076 scopus 로고    scopus 로고
    • Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects
    • Otsuki N, Dang NH, Kumagai E, et al. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol 2009;127:760-7
    • (2009) J Ethnopharmacol , vol.127 , pp. 760-767
    • Otsuki, N.1    Dang, N.H.2    Kumagai, E.3
  • 78
    • 78650008134 scopus 로고    scopus 로고
    • Therapeutic potential of mucoadhesive drug delivery systems-an updated patent review
    • Maurya SK, Pathak K, Bali V. Therapeutic potential of mucoadhesive drug delivery systems-an updated patent review. Recent Pat Drug Deliv Formul 2010;4:256-65
    • (2010) Recent Pat Drug Deliv Formul , vol.4 , pp. 256-265
    • Maurya, S.K.1    Pathak, K.2    Bali, V.3
  • 79
    • 84892733698 scopus 로고    scopus 로고
    • Evaluation of mucoadhesive carrier adjuvant: Toward an oral anthrax vaccine
    • Mangal S, Pawar D, Agrawal U, et al. Evaluation of mucoadhesive carrier adjuvant: Toward an oral anthrax vaccine. Artif Cells Nanomed Biotechnol 2013; 42(1):47-57
    • (2013) Artif Cells Nanomed Biotechnol , vol.42 , Issue.1 , pp. 47-57
    • Mangal, S.1    Pawar, D.2    Agrawal, U.3
  • 80
    • 77955262351 scopus 로고    scopus 로고
    • Plant glycans: Friend or foe in vaccine development?
    • Bosch D, Schots A. Plant glycans: friend or foe in vaccine development? Expert Rev Vaccines 2010;9(8):835-42
    • (2010) Expert Rev Vaccines , vol.9 , Issue.8 , pp. 835-842
    • Bosch, D.1    Schots, A.2
  • 81
    • 84893042280 scopus 로고    scopus 로고
    • The potential of Physcomitrella patens as a platform for the production of plant-based vaccines
    • Rosales-Mendoza S, Orellana-Escobedo L, Romero-Maldonado A, et al. The potential of Physcomitrella patens as a platform for the production of plant-based vaccines. Expert Rev Vaccines 2014;13(2):203-12
    • (2014) Expert Rev Vaccines , vol.13 , Issue.2 , pp. 203-212
    • Rosales-Mendoza, S.1    Orellana-Escobedo, L.2    Romero-Maldonado, A.3
  • 82
    • 84874058889 scopus 로고    scopus 로고
    • Virus-like particles produced in plants as potential vaccines
    • Scotti N, Rybicki EP. Virus-like particles produced in plants as potential vaccines. Expert Rev Vaccines 2013;12(2):211-24
    • (2013) Expert Rev Vaccines , vol.12 , Issue.2 , pp. 211-224
    • Scotti, N.1    Rybicki, E.P.2
  • 83
    • 36649009133 scopus 로고    scopus 로고
    • Polymer blends for controlled release coatings
    • Siepmann F, Siepmann J, Walther M, et al. Polymer blends for controlled release coatings. J Control Release 2008;125(1): 1-15
    • (2008) J Control Release , vol.125 , Issue.1 , pp. 1-15
    • Siepmann, F.1    Siepmann, J.2    Walther, M.3
  • 84
    • 84875124544 scopus 로고    scopus 로고
    • An update on pharmaceutical film coating for drug delivery
    • Felton LA, Porter SC. An update on pharmaceutical film coating for drug delivery. Expert Opin Drug Deliv 2013; 10(4):421-35
    • (2013) Expert Opin Drug Deliv , vol.10 , Issue.4 , pp. 421-435
    • Felton, L.A.1    Porter, S.C.2
  • 85
    • 29844448561 scopus 로고    scopus 로고
    • Mass production of somatic embryos expressing Escherichia coli heat-labile enterotoxin B subunit in Siberian ginseng
    • Kang TJ, Lee WS, Choi EG, et al. Mass production of somatic embryos expressing Escherichia coli heat-labile enterotoxin B subunit in Siberian ginseng. J Biotechnol 2006;121(2):124-33
    • (2006) J Biotechnol , vol.121 , Issue.2 , pp. 124-133
    • Kang, T.J.1    Lee, W.S.2    Choi, E.G.3
  • 86
    • 79952122609 scopus 로고    scopus 로고
    • Production of anti-amyloid b antibodies in mice fed rice expressing amyloid b
    • Nojima J, Ishii-Katsuno R, Futai E, et al. Production of anti-amyloid b antibodies in mice fed rice expressing amyloid b. Biosci Biotechnol Biochem 2011;75(2):396-400
    • (2011) Biosci Biotechnol Biochem , vol.75 , Issue.2 , pp. 396-400
    • Nojima, J.1    Ishii-Katsuno, R.2    Futai, E.3
  • 87
    • 84900988802 scopus 로고    scopus 로고
    • Protalix, [Last accessed 18 November 2013]
    • Protalix. Available from: www.protalix.com/development-pipeline/prx-112- oral-gaucher-disease.asp [Last accessed 18 November 2013]
  • 88
    • 0037435970 scopus 로고    scopus 로고
    • A non-toxic lectin for antigen delivery of plant-based mucosal vaccines
    • Medina-Bolivar F, Wright R, Funk V, et al. A non-toxic lectin for antigen delivery of plant-based mucosal vaccines. Vaccine 2003; 21(9-10):997-1005
    • (2003) Vaccine , vol.21 , Issue.9-10 , pp. 997-1005
    • Medina-Bolivar, F.1    Wright, R.2    Funk, V.3
  • 89
    • 33644915796 scopus 로고    scopus 로고
    • Potential of KM+ lectin in immunization against Leishmania amazonensis infection
    • Teixeira CR, Cavassani KA, Gomes RB, et al. Potential of KM+ lectin in immunization against Leishmania amazonensis infection. Vaccine 2006;24(15): 3001-8
    • (2006) Vaccine , vol.24 , Issue.15 , pp. 3001-3008
    • Teixeira, C.R.1    Cavassani, K.A.2    Gomes, R.B.3
  • 90
    • 34447647067 scopus 로고    scopus 로고
    • Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice
    • Song SK, Moldoveanu Z, Nguyen HH, et al. Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice. Vaccine 2007;25(34): 6359-66
    • (2007) Vaccine , vol.25 , Issue.34 , pp. 6359-6366
    • Song, S.K.1    Moldoveanu, Z.2    Nguyen, H.H.3
  • 91
    • 0344950492 scopus 로고    scopus 로고
    • Use of g-inulin/liposomes/vitamin e adjuvant combination in contraceptive vaccines
    • Fuentes P, Cooper PD, Barnadas R, et al. Use of g-inulin/liposomes/ vitamin E adjuvant combination in contraceptive vaccines. Int J Pharm 2003;257(1-2):85-95
    • (2003) Int J Pharm , vol.257 , Issue.1-2 , pp. 85-95
    • Fuentes, P.1    Cooper, P.D.2    Barnadas, R.3
  • 92
    • 1542301029 scopus 로고    scopus 로고
    • Oral vaccination against diphtheria using polyacryl starch microparticles as adjuvant
    • Rydell N, Sjöholm I. Oral vaccination against diphtheria using polyacryl starch microparticles as adjuvant. Vaccine 2004; 22(9-10):1265-74
    • (2004) Vaccine , vol.22 , Issue.9-10 , pp. 1265-1274
    • Rydell, N.1    Sjöholm, I.2
  • 93
    • 67349090621 scopus 로고    scopus 로고
    • Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity
    • Sun HX, Wang H, Xu HS, Nia Y. Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity. Vaccine 2009; 27(30):3984-91
    • (2009) Vaccine , vol.27 , Issue.30 , pp. 3984-3991
    • Sun, H.X.1    Wang, H.2    Xu, H.S.3    Nia, Y.4
  • 94
    • 67650178854 scopus 로고    scopus 로고
    • Immunological adjuvant effect of a water-soluble polysaccharide, CPP, from the roots of Codonopsis pilosula on the immune responses to ovalbumin in mice
    • Sun YX. Immunological adjuvant effect of a water-soluble polysaccharide, CPP, from the roots of Codonopsis pilosula on the immune responses to ovalbumin in mice. Chem Biodivers 2009;6(6):890-6
    • (2009) Chem Biodivers , vol.6 , Issue.6 , pp. 890-896
    • Sun, Y.X.1
  • 95
    • 0030981761 scopus 로고    scopus 로고
    • Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro
    • Krivorutchenko YL, Andronovskaja IB, Hinkula J, et al. Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro. Vaccine 1997; 15(12-13):1479-86
    • (1997) Vaccine , vol.15 , Issue.12-13 , pp. 1479-1486
    • Krivorutchenko, Y.L.1    Andronovskaja, I.B.2    Hinkula, J.3
  • 96
    • 0033979115 scopus 로고    scopus 로고
    • Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L
    • Estrada A, Katselis GS, Laarveld B, Barl B. Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L. Comp Immunol Microbiol Infect Dis 2000;23(1):27-43
    • (2000) Comp Immunol Microbiol Infect Dis , vol.23 , Issue.1 , pp. 27-43
    • Estrada, A.1    Katselis, G.S.2    Laarveld, B.3    Barl, B.4
  • 97
    • 33645242521 scopus 로고    scopus 로고
    • Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice
    • Sun XH. Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice. Vaccine 2006;24(17):3432-9
    • (2006) Vaccine , vol.24 , Issue.17 , pp. 3432-3439
    • Sun, X.H.1
  • 98
    • 82555192795 scopus 로고    scopus 로고
    • Quillaja brasiliensis saponins are less toxic than Quil A and have similar properties when used as an adjuvant for a viral antigen preparation
    • Silveira F, Cibulski SP, Varela AP, et al. Quillaja brasiliensis saponins are less toxic than Quil A and have similar properties when used as an adjuvant for a viral antigen preparation. Vaccine 2011;29(49): 9177-82
    • (2011) Vaccine , vol.29 , Issue.49 , pp. 9177-9182
    • Silveira, F.1    Cibulski, S.P.2    Varela, A.P.3


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