Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects

Journal of Ethnopharmacology

Volumn 127, Issue 3, 2010, Pages 760-767

  Otsuki, Noriko ^a   Dang, Nam H ^b   Kumagai, Emi ^a   Kondo, Akira ^c   Iwata, Satoshi ^a   Morimoto, Chikao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF FLORIDA   (United States)

^c Kondo Naika Hospital   (Japan)

Author keywords

Immunomodulatory effect; Leaf of Carica papaya; Th1 type cytokine; Traditional botanical medicine; Tumor growth inhibition

Indexed keywords

ANTINEOPLASTIC AGENT; CARICA PAPAYA EXTRACT; CASPASE 3; CASPASE 7; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 2; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; PLASMINOGEN ACTIVATOR INHIBITOR 2; THYMIDINE; TRITIUM; TUMOR NECROSIS FACTOR ALPHA; WATER;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOMODULATION; MICROARRAY ANALYSIS; MOLECULAR WEIGHT; PERIPHERAL BLOOD MONONUCLEAR CELL; PLANT LEAF; REAL TIME POLYMERASE CHAIN REACTION; TH1 CELL; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARICA; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOKINES; GENE EXPRESSION; GENETIC MARKERS; HUMANS; IMMUNOLOGIC FACTORS; ISOTOPES; LEUKOCYTES, MONONUCLEAR; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; THYMIDINE; UP-REGULATION;

CARICA PAPAYA;

EID: 76149088076     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.11.024     Document Type: Article

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