Quillaja brasiliensis saponins are less toxic than Quil A and have similar properties when used as an adjuvant for a viral antigen preparation

Vaccine

Volumn 29, Issue 49, 2011, Pages 9177-9182

  Silveira, F ^a   Cibulski, S P ^b   Varela, A P ^b   Marques J M ^c   Chabalgoity, A ^c   de Costa, F ^d   Yendo, A C A ^d   Gosmann, G ^d   Roehe, P M ^b,d   Fernandez C ^a   Ferreira, F ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b Instituto de Pesquisas Veterinarias Desiderio Finamor   (Brazil)

^c Facultad de Medicina   (Uruguay)

^d FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

BoHV 5; Humoral and cell responses; Low toxicity; Quillaja brasiliensis; Saponins; Virus vaccine

Indexed keywords

ALUMINUM POTASSIUM SULFATE; BOVINE HERPES VIRUS 5 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3 ANTIBODY; IMMUNOSTIMULATING AGENT; INTERLEUKIN 2; NEUTRALIZING ANTIBODY; QB 90U; QUIL A; SAPONIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BOVINE HERPES VIRUS; CD4+ T LYMPHOCYTE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DELAYED HYPERSENSITIVITY; FEMALE; GENE EXPRESSION; HEMOLYSIS; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PLANT LEAF; PRIORITY JOURNAL; QUILLAJA; QUILLAJA BRASILIENSIS; SPLEEN CELL; URUGUAY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CERCOPITHECUS AETHIOPS; CYTOKINES; FEMALE; HEMOLYSIS; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 5, BOVINE; IMMUNITY, HUMORAL; MICE; QUILLAJA; SAPONINS; SPLEEN; VERO CELLS;

EID: 82555192795     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.09.137     Document Type: Article

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