Heterocyclic aromatic hydrocarbons show estrogenic activity upon metabolization in a recombinant transactivation assay

Environmental Science and Technology

Volumn 48, Issue 10, 2014, Pages 5892-5901

  Brinkmann, Markus ^a   Maletz, Sibylle ^a   Krauss, Martin ^b   Bluhm, Kerstin ^a   Schiwy, Sabrina ^a   Kuckelkorn, Jochen ^a   Tiehm, Andreas ^c   Brack, Werner ^b   Hollert, Henner ^a,d,e,f  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^c Water Technology Center   (Germany)

^d NANJING UNIVERSITY   (China)

^e CHONGQING UNIVERSITY   (China)

^f Key Laboratory of Yangtze Water Environment Ministry of Education Tongji University ^*  (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; CHEMICAL ANALYSIS; GROUNDWATER; INDUSTRIAL PLANTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; ORGANIC COMPOUNDS; WOOD;

EQUIVALENCE FACTOR; ESTROGENIC ACTIVITIES; GROUNDWATER PLUMES; HETEROCYCLIC AROMATIC HYDROCARBONS; HYDROXYLATED METABOLITES; INDUSTRIAL FACILITIES; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS/MS); YEAST ESTROGEN SCREEN;

ENDOCRINOLOGY;

ACRIDINE; AROMATIC HYDROCARBON; DIBENZOFURAN; GROUND WATER; HETEROCYCLIC AROMATIC HYDROCARBON; INDOLE; QUINOLINE; SURFACE WATER; UNCLASSIFIED DRUG; XANTHENE;

AROMATIC HYDROCARBON; CHEMICAL ANALYSIS; COAL TAR; CONTAMINATED LAND; ESTROGENIC COMPOUND; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PLUME; RECOMBINATION;

ARTICLE; BIOTRANSFORMATION; BREAST CANCER CELL LINE; CONTROLLED STUDY; ESTROGEN ACTIVITY; HUMAN; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MCF 7 CELL LINE; METABOLIC ACTIVATION; TANDEM MASS SPECTROMETRY; TAUTOMER; TRANSACTIVATION ASSAY;

CHEMICAL ANALYSIS; GROUND WATER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; ORGANIC COMPOUNDS; WOOD;

BIOLOGICAL ASSAY; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; CONFIDENCE INTERVALS; ESTROGENS; HUMANS; POLYCYCLIC HYDROCARBONS, AROMATIC; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, ESTROGEN; RECOMBINATION, GENETIC; TANDEM MASS SPECTROMETRY; TRANSCRIPTIONAL ACTIVATION; WATER;

EID: 84901022835     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es405731j     Document Type: Article

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