Fate of carbamazepine during water treatment

Environmental Science and Technology

Volumn 43, Issue 16, 2009, Pages 6256-6261

  Kosjek, Tina ^a   Andersen, Henrik R ^b   Kompare, Boris ^c   Ledin, Anna ^b   Heath, Ester ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDONES; ACTIVATED SLUDGE; BIOLOGICAL TREATMENT; CARBAMAZEPINE; CHLORINE DIOXIDES; ION TRAPS; PARENT COMPOUNDS; QUADRUPOLES; QUINAZOLINES; SAMPLE ANALYSIS; TIME-OF-FLIGHT MASS SPECTROMETERS; TRANSFORMATION PRODUCTS; TREATMENT PROCESS; TREATMENT TECHNOLOGIES; UV IRRADIATION; UV TREATMENT; WATER TREATMENT TECHNOLOGIES;

ALDEHYDES; AMIDES; BIOCHEMICAL ENGINEERING; BIODEGRADATION; CHLORINE; MASS SPECTROMETERS; MASS SPECTROMETRY; OXIDATION;

CHEMICALS REMOVAL (WATER TREATMENT);

1 (2 BENZALDEHYDE) (1H,3H) QUINAZOLINE 2,4 DIONE; 9 HYDROXY ACRIDINE; ACRIDINE 9 CARBALDEHYDE; ACRIDINE DERIVATIVE; ACRIDONE DERIVATIVE; ACRIDONE N CARBALDEHYDE; CARBAMAZEPINE; CHLORINE DIOXIDE; DIBENZAZEPINE; HYDROXY (9H,10H) ACRIDINE 9 CARBALDEHYDE; UNCLASSIFIED DRUG;

ALDEHYDE; BIODEGRADATION; DRUG; MASS SPECTROMETRY; ORGANIC POLLUTANT; POLLUTANT REMOVAL; TRANSFORMATION; ULTRAVIOLET RADIATION; WASTE TECHNOLOGY; WATER TREATMENT;

ACTIVATED SLUDGE; ARTICLE; BIODEGRADABILITY; CONTROLLED STUDY; INTERMETHOD COMPARISON; ION TRAP MASS SPECTROMETRY; OXIDATION; QUADRUPOLE MASS SPECTROMETRY; SAMPLE; TIME OF FLIGHT MASS SPECTROMETRY; ULTRAVIOLET RADIATION; WATER ANALYSIS; WATER TREATMENT;

BIODEGRADATION, ENVIRONMENTAL; BIOREACTORS; CARBAMAZEPINE; CHLORINE COMPOUNDS; OXIDES; ULTRAVIOLET RAYS; WATER PURIFICATION;

EID: 68849100710     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es900070h     Document Type: Article

References (28)

1. Ternes, T. A. Occurence of drugs in German sewage treatment plants and rivers. Water Res. 1998, 32, 3245-3260.
2. Ferrari, B.; Mons, R.; Vollat, B.; Fraysse, B.; Praxéus, N.; LoGiudice, R.; Pollio, A.; Garric, J. Environmental risk assessment of six human pharmaceuticals: Are the current environmental risk assessment procedures sufficient for the protection of aquatic environment? Environ. Toxicol. Chem. 2004, 23, 1344-1354.
3. Jones, O. A. H.; Voulvoulis, N.; Lester, J. N. Aquatic environmental assessment of the top 25 English prescription pharmaceuticals. Water Res. 2002, 36, 5013-5022.
4. McNamara, J. O. Drugs effective in the therapy of epilepsies. In Goodman & Gilman's Pharmacological Basis of Therapeutics, 9th ed.; Hardman, J. G., Limbird, L. E., Eds.; The McGraw-Hill Companies: New York, 1996.
5. Ternes, T. A.; Meisenheimer, M.; McDowell, D.; Sacher, F.; Brauch, H. J.; Haist-Gulde, B.; Preuss, G.; Wilme, U.; Zulei-Seibert, N. Removal of pharmaceuticals during drinking water treatment. Environ. Sci. Technol. 2002, 36, 3855-3863.
6. Scheytt, T.; Mersmann, P.; Lindstädt, R.; Heberer, T. Determination of sorption coefficients of pharmaceutically active substances carbamazepine, diclofenac, and ibuprofen, in sandy sediments. Chemosphere 2005, 60, 245-253.
7. Clara, M.; Strenn, B.; Kreuzinger, N. Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of Carbamazepine in wastewater treatment and during groundwater infiltration. Water Res. 2004, 38, 947-954.
8. Gebhardt, W.; Schröder, H. F. Liquid chromatography-(tandem) mass spectrometry for the follow-up of the elimination of persistent pharmaceuticals during wastewater treatment applying biological wastewater treatment and advanced oxidation. J. Chromatogr., A 2007, 1160, 34-43.
9. Ollers, S.; Singer, H. P.; Fassler, P.; Muller, S. R. Simultaneous quantification of neutral and acidic pharmaceuticals and pesticides at the low-ng/l level in surface and waste water. J. Chromatogr., A 2001, 911, 225-234.
10. Metcalfe, C. D.; Miao, X. S.; Koenig, B. G.; Struger, J. Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower great lakes, Canada. Environ. Toxicol. Chem. 2003, 22, 2881-2889.
11. Andreozzi, R.; Marotta, R.; Paxéus, N. Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment. Chemosphere 2003, 50, 1319-1330.
12. Ternes, T. A. Pharmaceuticals and Metabolites as Contaminants of the Aquatic Environment. In Pharmaceuticals and Personal Care Products in the Environment: Scientific and Regulatory Issues; Daughton, C. G., Jones-Lepp, T. L., Eds.; ACS Symposium Series 791; American Chemical Society: Washingon, DC, 2001.
13. Huber, M. M.; Korhonen, S.; Ternes, T. A.; Von Gunten, U. Oxidation of pharmaceuticals during water treatment with chlorine dioxide. Water Res. 2005, 39, 3607-3617.
14. Vogna, D.; Marotta, R.; Andreozzi, R.; Napolitano, A.; d'Ischia, M. Kinetic and chemical assessment of the UV/H2O2 treatment of antiepileptic drug carbamazepine. Chemosphere 2004, 54, 497-505.
15. Doll, T. E.; Frimmel, F. H. Removal of selected persistent pollutants by heterogeneous photocatalysis in water. Catal. Today 2005, 101, 195-202.
16. Chiron, S.; Minero, C.; Vione, D. Photodegradation processes of the antiepileptic drug carbamazepine, relevant to estuarine waters. Environ. Sci. Technol. 2006, 40, 5977-5983.
17. Encarnación, I. N.; Arce, R. Light-induced transformations of aza-aromatic pollutants adsorbed on models of atmospheric particulate matter: Acridine and 9(10-H) acridone. Atmos. Environ. 2007, 41, 6771-6783.
18. Wiegman, S.; Barranguet, C.; Spijkerman, E.; Kraak, M. H. S.; Admiraal, W. The role of ultraviolet-adaptation of a marine diatom in photoenhanced toxicity of acridine. Environ. Toxicol. Chem. 2003, 22, 591-598.
19. McDowell, D. C.; Huber, M. M.; Wagner, M.; Von Gunten, U.; Ternes, T. A. Ozonation of carbamazepine in drinking water: Identification and kinetic study of major oxidation products. Environ. Sci. Technol. 2005, 39, 8014-8022.
20. Kosjek, T.; Heath, E.; Petrović, M.; Barceló, D. Mass spectrometry for identifying pharmaceutical biotransformation products in the environment. TrAC, Trends Anal. Chem. 2007, 26, 1076-1085.
21. Kosjek, T.; Heath, E.; Kompare, B. Removal of pharmaceutical residues in a pilot wastewater treatment plant. Anal. Bioanal. Chem. 2007, 387, 1379-1387.
22. Kraigher, B.; Kosjek, T.; Heath, E.; Kompare, B.; Mandić-Mulec, I. Influence of pharmaceutical residues on the structure of activated sludge bacterial communities in wastewater treatment bioreactors. Water Res. 2008, 42, 4578-4588.
23. Kosjek, T.; Žeigon, D.; Kralj, B.; Heath, E. The use of quadrupole time-of-flight mass spectrometer for the elucidation of diclofenac biotransformation products in wastewater. J. Chromatogr., A 2008, 1215, 57-63.
24. de Voogt, P.; Bleeker, E. A. J.; van Vlaardingen, P. L. A.; Fernández, A.; Slobodník, J.; Wever, H.; Kraak, M. H. S. Formation and identification of azaarene transformation products from aquatic invertebrate and algal metabolism. J. Chromatogr., B 1999, 724, 265-274.
25. Schwarzenbach, R. P., Gschwend; P. M., Imboden, D. M., Eds. Environmental Organic Chemistry; John Wiley & Sons, Inc.: New York, 1993.
26. Eto, S.; Tanaka, N.; Noda, H.; Noda, A. Chiral separation of 10,11-dihydro-10,11-trans-dihydroxycarbamazepine, a metabolite of carbamazepine with two asimetric carbons, in human serum. J. Chromatogr., B 1996, 677, 325-330.
27. Furst, S. M.; Uetrecht, J. P. The effect of carbamazepine and its reactive metabolite 9-acridine carbaldehyde on immune cell function in vitro. Int. J. Immunopharmacol. 1995, 17, 445-452.
28. Bleeker, E. A. J.; Leslie, H. A.; Groenendijk, D.; Plans, M.; Admiraal, W. Effects of exposure to azaarenes on emergence and mouthpart developement in the midge Chironomus riparius (Diptera: Chironomidae). Environ. Toxicol. Chem. 1999, 18, 1829-1834.