Quantitative multi-parametric evaluation of centrosome declustering drugs: Centrosome amplification, mitotic phenotype, cell cycle and death

Cell Death and Disease

Volumn 5, Issue 5, 2014, Pages

  Ogden, A ^a   Cheng, A ^a   Rida, P C G ^a   Pannu, V ^a   Osan, R ^a   Clewley, R ^a   Aneja, R ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Centrosome amplification; Centrosome declustering; Microtubule targeting agents; Mitotic arrest; Spindle multipolarity; Spindle pole amplification

Indexed keywords

ALPHA TUBULIN; ANTINEOPLASTIC AGENT; AURORA A KINASE; CASPASE 3; CENTRIN; CENTROSOME DECLUSTERING DRUG; CYCLIN B1; CYCLIN E; GAMMA TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DEATH; CELL POLARITY; CENTROSOME; CONCENTRATION RESPONSE; CONCEPTUAL FRAMEWORK; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SENSITIVITY; FLOW CYTOMETRY; HELA CELL LINE; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; MALIGNANT TRANSFORMATION; MITOSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPINDLE CELL; SPINDLE POLE; TUMOR GROWTH; CELL CYCLE CHECKPOINT; CELL CYCLE G1 PHASE; DRUG EFFECTS; PHENOTYPE; SPINDLE APPARATUS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CYCLE CHECKPOINTS; CELL DEATH; CELL LINE, TUMOR; CELL POLARITY; CENTROSOME; G1 PHASE; HUMANS; MITOSIS; PHENOTYPE; SPINDLE APPARATUS;

EID: 84901022581     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.164     Document Type: Article

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