Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: A novel chemotherapeutic approach

Cell Death and Disease

Volumn 3, Issue 7, 2012, Pages

  Pannu, V ^a   Rida, P C G ^a   Ogden, A ^a   Clewley, R ^a   Cheng, A ^a   Karna, P ^a   Lopus, M ^b   Mishra, R C ^a   Zhou, J ^c   Aneja, R ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NANKAI UNIVERSITY   (China)

Author keywords

centrosome declustering; de novo centrosome amplification; metaphase catastrophe; microtubule dynamics; tubulin binding agent

Indexed keywords

3 9 BROMO 5 (4,5 DIMETHOXY 1,3 DIHYDROISOBENZOFURAN 1 YL) 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO [4,5 G]ISOQUINOLINE; ALPHA TUBULIN; CENTRIN; DNA; DOXORUBICIN; ISOQUINOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TIRON; UNCLASSIFIED DRUG; 9 BROMO 5 (4,5 DIMETHOXY 1,3 DIHYDROISOBENZOFURAN 1 YL) 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO (1,3) DIOXOLO(4,5 G)ISOQUINOLINE; 9-BROMO-5-(4,5-DIMETHOXY-1,3-DIHYDROISOBENZOFURAN-1-YL)-4-METHOXY-6-METHYL-5,6,7,8-TETRAHYDRO-(1,3)-DIOXOLO(4,5-G)ISOQUINOLINE; CASPASE; DRUG DERIVATIVE; NOSCAPINE;

ARTICLE; ATTENUATION; CELL EXPANSION; CELL POLARITY; CELLULAR DISTRIBUTION; CENTROSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINESIS; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; METAPHASE; MITOSIS; PHENOTYPE; PRIORITY JOURNAL; S PHASE CELL CYCLE CHECKPOINT; SPINDLE CELL; APOPTOSIS; AUTOPHAGY; DRUG EFFECT; MALE; METABOLISM; MITOSIS SPINDLE; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CASPASES; CELL LINE, TUMOR; CENTROSOME; DNA BREAKS, DOUBLE-STRANDED; DOXORUBICIN; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MALE; METAPHASE; MITOSIS; MITOTIC SPINDLE APPARATUS; NOSCAPINE; REACTIVE OXYGEN SPECIES;

EID: 84864874569     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.82     Document Type: Article

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