A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering

Cell Death and Differentiation

Volumn 18, Issue 4, 2011, Pages 632-644

  Karna, P ^a   Rida, P C G ^b   Pannu, V ^a   Gupta, K K ^c   Dalton, W B ^b   Joshi, H ^b   Yang, V W ^b   Zhou, J ^d   Aneja, R ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

^d NANKAI UNIVERSITY   (China)

Author keywords

aneuploidy; apoptosis; centrosome amplification; centrosome declustering; microtubule dynamics; tubulin binding agent

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA A KINASE; CLIP 170 PROTEIN; EB1 PROTEIN; EM 011; MICROTUBULE PROTEIN; PLK4 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANAPHASE; ANEUPLOIDY; APOPTOSIS; ARTICLE; BIOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL FATE; CELL POPULATION; CELL PROLIFERATION; CELLULAR PARAMETERS; CENTRIOLE; CENTROSOME AMPLIFICATION; CENTROSOME DECLUSTERING; CONTROLLED STUDY; CYTOKINESIS; DRUG CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INTERPHASE; METAPHASE; MICROTUBULE; MITOSIS INHIBITION; PRIORITY JOURNAL; SPINDLE CELL; SPINDLE MULTIPOLARITY; TELOPHASE; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CENTROSOME; DIOXOLES; G1 PHASE; G2 PHASE; HUMANS; ISOQUINOLINES; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; S PHASE; TUBULIN MODULATORS; UP-REGULATION;

EID: 79952623009     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.133     Document Type: Article

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