Postsynaptic scaffold protein Homer 1a protects against traumatic brain injury via regulating group i metabotropic glutamate receptors

Cell Death and Disease

Volumn 5, Issue 4, 2014, Pages

  Luo, P ^a   Chen, T ^a   Zhao, Y ^a   Zhang, L ^a   Yang, Y ^a   Liu, W ^a   Li, S ^a   Rao, W ^a   Dai, S ^a   Yang, J ^b   Fei, Z ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b VA BOSTON HEALTHCARE SYSTEM   (United States)

Author keywords

Excitotoxicity; Metabotropic glutamate receptor; Postsynaptic density; Scaffold protein; Traumatic brain injury

Indexed keywords

CALCIUM; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN HOMER 1A; CARRIER PROTEIN; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; NEUROPROTECTIVE AGENT; PROTEIN HOMER; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN FUNCTION; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; EXCITOTOXICITY; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; AGONISTS; ANIMAL; BRAIN; BRAIN INJURIES; C57BL MOUSE; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; SYNAPSE;

ANIMALS; BRAIN; BRAIN INJURIES; CALCIUM; CARRIER PROTEINS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MAP KINASE SIGNALING SYSTEM; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN KINASE C; RECEPTOR, METABOTROPIC GLUTAMATE 5; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPSES;

EID: 84901011408     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.116     Document Type: Article

References (39)

1. Luo P, Fei F, Zhang L, Qu Y, Fei Z. The role of glutamate receptors in traumatic brain injury: implications for postsynaptic density in pathophysiology. Brain Res Bull 2011; 85: 313-320.
2. Loane DJ, Faden AI. Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol Sci 2010; 31: 596-604.
3. Zhou L, Li F, Xu HB, Luo CX, Wu HY, Zhu MM et al. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med 2010; 16: 1439-1443.
4. Cook DJ, Teves L, Tymianski M. Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain. Nature 2012; 483: 213-217.
5. Bach A, Clausen BH, Moller M, Vestergaard B, Chi CN, Round A et al. A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. Proc Natl Acad Sci USA 2012; 109: 3317-3322.
6. Kato A, Ozawa F, Saitoh Y, Hirai K, Inokuchi K. Vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis. FEBS Lett 1997; 412: 183-189.
7. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 1997; 386: 284-288.
8. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 1998; 21: 707-716.
9. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 1998; 21: 717-726.
10. Sun J, Tadokoro S, Imanaka T, Murakami SD, Nakamura M, Kashiwada K et al. Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. FEBS Lett 1998; 437: 304-308.
11. Kato A, Ozawa F, Saitoh Y, Fukazawa Y, Sugiyama H, Inokuchi K. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J Biol Chem 1998; 273: 23969-23975.
12. Xiao B, Tu JC, Worley PF. Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol 2000; 10: 370-374.
13. Hu JH, Park JM, Park S, Xiao B, Dehoff MH, Kim S et al. Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron 2010; 68: 1128-1142.
14. Tappe A, Klugmann M, Luo C, Hirlinger D, Agarwal N, Benrath J et al. Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain. Nat Med 2006; 12: 677-681.
15. Ronesi JA, Collins KA, Hays SA, Tsai NP, Guo W, Birnbaum SG et al. Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat Neurosci 2012; 15: 431-440; S431.
16. Mukhin AG, Ivanova SA, Knoblach SM, Faden AI. New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity. J Neurotrauma 1997; 14: 651-663.
17. Gong QZ, Delahunty TM, Hamm RJ, Lyeth BG. Metabotropic glutamate antagonist, MCPG, treatment of traumatic brain injury in rats. Brain Res 1995; 700: 299-302.
18. Camon L, Vives P, de Vera N, Martinez E. Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine. J Neurosci Res 1998; 51: 339-348.
19. Faden AI, O'Leary DM, Fan L, Bao W, Mullins PG, Movsesyan VA. Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma. Exp Neurol 2001; 167: 435-444.
20. Mukhin A, Fan L, Faden AI. Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. J Neurosci 1996; 16: 6012-6020.
21. Zhou F, Hongmin B, Xiang Z, Enyu L. Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury. J Clin Neurosci 2003; 10: 684-688.
22. Berent-Spillson A, Robinson AM, Golovoy D, Slusher B, Rojas C, Russell JW. Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3. J Neurochem 2004; 89: 90-99.
23. Fei Z, Zhang X, Bai HM, Jiang XF, Wang XL. Metabotropic glutamate receptor antagonists and agonists: potential neuroprotectors in diffuse brain injury. J Clin Neurosci 2006; 13: 1023-1027.
24. Chen T, Cao L, Dong W, Luo P, Liu W, Qu Y et al. Protective effects of mGluR5 positive modulators against traumatic neuronal injury through PKC-dependent activation of MEK/ ERK pathway. Neurochem Res 2012; 37: 983-990.
25. Chen T, Zhang L, Qu Y, Huo K, Jiang X, Fei Z. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med 2012; 29: 630-636.
26. Loane DJ, Stoica BA, Byrnes KR, Jeong W, Faden AI. Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury. J Neurotrauma 2013; 30: 403-412.
27. Byrnes KR, Loane DJ, Stoica BA, Zhang J, Faden AI. Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. J Neuroinflammation 2012; 9: 43.
28. Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J et al. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci 2012; 15: 836-844.
29. Niswender CM, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol 2010; 50: 295-322.
30. Lu KT, Cheng NC, Wu CY, Yang YL. NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascade. Crit Care Med 2008; 36: 917-922.
31. Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME et al. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab 2002; 22: 444-452.
32. Zhao Y, Luo P, Guo Q, Li S, Zhang L, Zhao M et al. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. Exp Neurol 2012; 237: 489-498.
33. Mao L, Yang L, Tang Q, Samdani S, Zhang G, Wang JQ. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci 2005; 25: 2741-2752.
34. Kammermeier PJ, Worley PF. Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors. Proc Natl Acad Sci USA 2007; 104: 6055-6060.
35. Luo P, Zhao Y, Li D, Chen T, Li S, Chao X et al. Protective effect of Homer 1a on tumor necrosis factor-alpha with cycloheximide-induced apoptosis is mediated by mitogenactivated protein kinase pathways. Apoptosis 2012; 17: 975-988.
36. Chen T, Fei F, Jiang XF, Zhang L, Qu Y, Huo K et al. Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons. Free Radic Biol Med 2012; 52: 208-217.
37. Luo P, Chen T, Zhao Y, Xu H, Huo K, Zhao M et al. Protective effect of Homer 1a against hydrogen peroxide-induced oxidative stress in PC12 cells. Free Radic Res 2012; 46: 766-776.
38. Ribeiro FM, Paquet M, Cregan SP, Ferguson SS. Group I metabotropic glutamate receptor signalling and its implication in neurological disease. CNS Neurol Disord Drug Targets 2010; 9: 574-595.
39. Flierl MA, Stahel PF, Beauchamp KM, Morgan SJ, Smith WR, Shohami E. Mouse closed head injury model induced by a weight-drop device. Nat Protoc 2009; 4: 1328-1337.