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Volumn 37, Issue 5, 2012, Pages 983-990

Protective effects of mGluR5 positive modulators against traumatic neuronal injury through PKC-dependent activation of MEK/ERK pathway

Author keywords

ERK; Neuroprotective effect; PKC; Traumatic brain injury

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 CHLORO 5 HYDROXYPHENYLGLYCINE; 3 CYANO N (1,3 DIPHENYL 1H PYRAZOL 5 YL)BENZAMIDE; CASPASE 3; CHELERYTHRINE; LACTATE DEHYDROGENASE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 84862903594     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0691-z     Document Type: Article
Times cited : (48)

References (36)
  • 1
    • 33947584713 scopus 로고    scopus 로고
    • Genetic influences on outcome following traumatic brain injury
    • DOI 10.1007/s11064-006-9251-3
    • Jordan BD (2007) Genetic influences on outcome following traumatic brain injury. Neurochem Res 32:905-915 (Pubitemid 46481316)
    • (2007) Neurochemical Research , vol.32 , Issue.4-5 , pp. 905-915
    • Jordan, B.D.1
  • 2
    • 0034584897 scopus 로고    scopus 로고
    • Cognitive impairments following traumatic brain injury. Etiologies and interventions
    • Davis AE (2000) Cognitive impairments following traumatic brain injury. Etiologies and interventions. Crit Care Nurs Clin North Am 12:447-456
    • (2000) Crit Care Nurs Clin North Am , vol.12 , pp. 447-456
    • Davis, A.E.1
  • 3
    • 79451471769 scopus 로고    scopus 로고
    • Salvianolic acid B attenuates brain damage and inflammation after traumatic brain injury in mice
    • Chen T et al (2011) Salvianolic acid B attenuates brain damage and inflammation after traumatic brain injury in mice. Brain Res Bull 84:163-168
    • (2011) Brain Res Bull , vol.84 , pp. 163-168
    • Chen, T.1
  • 4
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi DW (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 5
    • 39149103434 scopus 로고    scopus 로고
    • Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate receptors
    • Fei Z et al (2007) Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate receptors. BMC Neurosci 8:96
    • (2007) BMC Neurosci , vol.8 , pp. 96
    • Fei, Z.1
  • 7
    • 17744387125 scopus 로고    scopus 로고
    • Ionotropic and metabotropic glutamate receptor structure and pharmacology
    • DOI 10.1007/s00213-005-2200-z
    • Kew JN, Kemp JA (2005) Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacol Berl 179:4-29 (Pubitemid 40576690)
    • (2005) Psychopharmacology , vol.179 , Issue.1 , pp. 4-29
    • Kew, J.N.C.1    Kemp, J.A.2
  • 8
    • 0028912822 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin JP, Duvoisin R (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34:1-26
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 10
    • 33750967907 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor antagonists and agonists: Potential neuroprotectors in diffuse brain injury
    • DOI 10.1016/j.jocn.2005.11.042, PII S0967586806004309
    • Fei Z et al (2006) Metabotropic glutamate receptor antagonists and agonists: potential neuroprotectors in diffuse brain injury. J Clin Neurosci 13:1023-1027 (Pubitemid 44750674)
    • (2006) Journal of Clinical Neuroscience , vol.13 , Issue.10 , pp. 1023-1027
    • Fei, Z.1    Zhang, X.2    Bai, H.-m.3    Jiang, X.-f.4    Wang, X.-l.5
  • 11
    • 0030029427 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
    • DOI 10.1016/S0166-2236(96)20019-0
    • Nicoletti F et al (1996) Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci 19:267-271 (Pubitemid 26000672)
    • (1996) Trends in Neurosciences , vol.19 , Issue.7 , pp. 267-271
    • Nicoletti, F.1    Bruno, V.2    Copani, A.3    Casabona, G.4    Knopfel, T.5
  • 12
    • 56349161503 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors in glial cells
    • D'Antoni S et al (2008) Metabotropic glutamate receptors in glial cells. Neurochem Res 33:2436-2443
    • (2008) Neurochem Res , vol.33 , pp. 2436-2443
    • D'Antoni, S.1
  • 13
    • 77950958966 scopus 로고    scopus 로고
    • Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys
    • Morin N et al (2010) Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys. Neuropharmacology 58:981-986
    • (2010) Neuropharmacology , vol.58 , pp. 981-986
    • Morin, N.1
  • 14
    • 84856091327 scopus 로고    scopus 로고
    • Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration
    • doi:10.1016/j.neuropharm.2010.11.013
    • Parmentier-Batteur S et al (2010) Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration. Neuropharmacology. doi:10.1016/j.neuropharm.2010.11.013
    • (2010) Neuropharmacology
    • Parmentier-Batteur, S.1
  • 15
    • 0037071893 scopus 로고    scopus 로고
    • Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription
    • DOI 10.1016/S0896-6273(02)00737-7
    • Redmond L, Kashani AH, Ghosh A (2002) Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron 34:999-1010 (Pubitemid 34722288)
    • (2002) Neuron , vol.34 , Issue.6 , pp. 999-1010
    • Redmond, L.1    Kashani, A.H.2    Ghosh, A.3
  • 16
    • 0035134134 scopus 로고    scopus 로고
    • Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma
    • DOI 10.1006/exnr.2000.7577
    • Faden AI et al (2001) Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improvesoOutcome after brain trauma. Exp Neurol 167:435-444 (Pubitemid 32150901)
    • (2001) Experimental Neurology , vol.167 , Issue.2 , pp. 435-444
    • Faden, A.I.1    O'Leary, D.M.2    Fan, L.3    Bao, W.4    Mullins, P.G.M.5    Movsesyan, V.A.6
  • 17
    • 24044495532 scopus 로고    scopus 로고
    • Traumatic injury induced homer-1a gene expression in cultured cortical neurons of rat
    • DOI 10.1016/j.neulet.2005.07.014, PII S0304394005007937
    • Huang WD, Fei Z, Zhang X (2005) Traumatic injury induced homer-1a gene expression in cultured cortical neurons of rat. Neurosci Lett 389:46-50 (Pubitemid 41219432)
    • (2005) Neuroscience Letters , vol.389 , Issue.1 , pp. 46-50
    • Huang, W.-D.1    Fei, Z.2    Zhang, X.3
  • 18
    • 0033638723 scopus 로고    scopus 로고
    • Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
    • O'Leary DM et al (2000) Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 131:1429-1437
    • (2000) Br J Pharmacol , vol.131 , pp. 1429-1437
    • O'Leary, D.M.1
  • 19
    • 0035197286 scopus 로고    scopus 로고
    • MGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors
    • Movsesyan VA et al (2001) mGluR5 antagonists 2-methyl-6-(phenylethynyl)- pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 296:41-47 (Pubitemid 32015058)
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.296 , Issue.1 , pp. 41-47
    • Movsesyan, V.A.1    O'Leary, D.M.2    Fan, L.3    Bao, W.4    Mullins, P.G.M.5    Knoblach, S.M.6    Faden, A.I.7
  • 20
    • 3042662255 scopus 로고    scopus 로고
    • MGLuR5 activation reduces β-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor
    • DOI 10.1111/j.1471-4159.2004.02451.x
    • Movsesyan VA, Stoica BA, Faden AI (2004) MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. J Neurochem 89:1528-1536 (Pubitemid 38802674)
    • (2004) Journal of Neurochemistry , vol.89 , Issue.6 , pp. 1528-1536
    • Movsesyan, V.A.1    Stoica, B.A.2    Faden, A.I.3
  • 21
    • 28844449366 scopus 로고    scopus 로고
    • The inhibition of glycogen synthase kinase 3β by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Aβ peptides
    • DOI 10.1111/j.1471-4159.2005.03474.x
    • Liu F et al (2005) The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides. J Neurochem 95:1363-1372 (Pubitemid 41779261)
    • (2005) Journal of Neurochemistry , vol.95 , Issue.5 , pp. 1363-1372
    • Liu, F.1    Gong, X.2    Zhang, G.3    Marquis, K.4    Reinhart, P.5    Andree, T.H.6
  • 22
    • 0030894148 scopus 로고    scopus 로고
    • 1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
    • DOI 10.1016/S0028-3908(97)00001-4, PII S0028390897000014
    • Doherty AJ et al (1997) (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36:265-267 (Pubitemid 27149516)
    • (1997) Neuropharmacology , vol.36 , Issue.2 , pp. 265-267
    • Doherty, A.J.1    Palmer, M.J.2    Henley, J.M.3    Collingridge, G.L.4    Jane, D.E.5
  • 23
    • 50249132439 scopus 로고    scopus 로고
    • Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice
    • You Z et al (2008) Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab 28:1564-1573
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1564-1573
    • You, Z.1
  • 24
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • Kim EK, Choi EJ (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 1802: 396-405
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 396-405
    • Kim, E.K.1    Choi, E.J.2
  • 25
    • 70450206734 scopus 로고    scopus 로고
    • Traumatic injury activates MAP kinases in astrocytes: Mechanisms of hypothermia and hyperthermia
    • Huang T et al (2009) Traumatic injury activates MAP kinases in astrocytes: mechanisms of hypothermia and hyperthermia. J Neurotrauma 26:1535-1545
    • (2009) J Neurotrauma , vol.26 , pp. 1535-1545
    • Huang, T.1
  • 26
    • 79955620230 scopus 로고    scopus 로고
    • Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: Involvement of mitogen-activated protein kinase pathway
    • Chen T et al (2011) Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: involvement of mitogen-activated protein kinase pathway. Neuroscience 183:203-211
    • (2011) Neuroscience , vol.183 , pp. 203-211
    • Chen, T.1
  • 29
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z et al (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1
  • 31
    • 0035282715 scopus 로고    scopus 로고
    • Molecular determinants of metabotropic glutamate receptor signaling
    • DOI 10.1016/S0165-6147(00)01635-7, PII S0165614700016357
    • De Blasi A et al (2001) Molecular determinants of metabotropic glutamate receptor signaling. Trends Pharmacol Sci 22:114-120 (Pubitemid 32181842)
    • (2001) Trends in Pharmacological Sciences , vol.22 , Issue.3 , pp. 114-120
    • De Blasi, A.1    Conn, P.J.2    Pin, J.-P.3    Nicoletti, F.4
  • 32
    • 0029060391 scopus 로고
    • Protein kinase C and lipid signaling for sustained cellular responses
    • Nishizuka Y (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9:484-496
    • (1995) FASEB J , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 33
    • 33745089618 scopus 로고    scopus 로고
    • Enhancement of insulin-induced PI3K/Akt/GSK-3β and ERK signaling by neuronal nicotinic receptor/PKC-α/ERK pathway: Up-regulation of IRS-1/-2 mRNA and protein in adrenal chromaffin cells
    • DOI 10.1111/j.1471-4159.2006.03846.x
    • Sugano T et al (2006) Enhancement of insulin-induced PI3 K/Akt/GSK-3beta and ERK signaling by neuronal nicotinic receptor/PKC-alpha/ERK pathway: up-regulation of IRS-1/-2 mRNA and protein in adrenal chromaffin cells. J Neurochem 98:20-33 (Pubitemid 43882929)
    • (2006) Journal of Neurochemistry , vol.98 , Issue.1 , pp. 20-33
    • Sugano, T.1    Yanagita, T.2    Yokoo, H.3    Satoh, S.4    Kobayashi, H.5    Wada, A.6
  • 34
    • 4644320317 scopus 로고    scopus 로고
    • Posttranslational mechanisms of peripheral sensitization
    • DOI 10.1002/neu.20083
    • Bhave G, Gereau RWt (2004) Posttranslational mechanisms of peripheral sensitization. J Neurobiol 61:88-106 (Pubitemid 39287772)
    • (2004) Journal of Neurobiology , vol.61 , Issue.1 , pp. 88-106
    • Bhave, G.1    Gereau IV, R.W.2
  • 35
    • 26244436792 scopus 로고    scopus 로고
    • Inflammation-mediated hyperexcitability of sensory neurons
    • DOI 10.1159/000087653
    • Gold MS, Flake NM (2005) Inflammation-mediated hyperexcitability of sensory neurons. Neurosignals 14:147-157 (Pubitemid 41417103)
    • (2005) NeuroSignals , vol.14 , Issue.4 , pp. 147-157
    • Gold, M.S.1    Flake, N.M.2
  • 36
    • 33644685637 scopus 로고    scopus 로고
    • The role of protein kinase C in cerebral ischemic and reperfusion injury
    • Bright R, Mochly-Rosen D (2005) The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke 36:2781-2790
    • (2005) Stroke , vol.36 , pp. 2781-2790
    • Bright, R.1    Mochly-Rosen, D.2


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