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Volumn 11, Issue 1, 2014, Pages 85-95

Deep sequencing approaches to antibody discovery

Author keywords

Antibody discovery; Biotherapeutic; Deep sequencing; Diversity; Phage display; Rodent immunization

Indexed keywords

ANTIBODY; CD40 LIGAND; INTERLEUKIN 21; TRANSCRIPTOME;

EID: 84900851347     PISSN: 15701638     EISSN: 18756220     Source Type: Journal    
DOI: 10.2174/15701638113106660040     Document Type: Article
Times cited : (7)

References (55)
  • 1
    • 77957361348 scopus 로고    scopus 로고
    • Development trends for human monoclonal antibody therapeutics
    • Nelson AL, Dhimolea E, Reichert JM. Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov 2010; 9(10): 767-74.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.10 , pp. 767-774
    • Nelson, A.L.1    Dhimolea, E.2    Reichert, J.M.3
  • 2
    • 84860896956 scopus 로고    scopus 로고
    • Marketed therapeutic antibodies compendium
    • Reichert JM. Marketed therapeutic antibodies compendium. MAbs 2012; 4(3): 413-5.
    • (2012) MAbs , vol.4 , Issue.3 , pp. 413-415
    • Reichert, J.M.1
  • 3
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert JM. Antibody-based therapeutics to watch in 2011. MAbs 2011; 3(1): 76-99.
    • (2011) MAbs , vol.3 , Issue.1 , pp. 76-99
    • Reichert, J.M.1
  • 4
    • 84856800190 scopus 로고    scopus 로고
    • Which are the antibodies to watch in 2012
    • Reichert JM. Which are the antibodies to watch in 2012 MAbs 2012; 4(1): 1-3.
    • (2012) MAbs , vol.4 , Issue.1 , pp. 1-3
    • Reichert, J.M.1
  • 5
    • 84864920004 scopus 로고    scopus 로고
    • Comparison of next-generation sequencing systems
    • Liu L, Li Y, Li S, et al. Comparison of next-generation sequencing systems. J Biomed Biotechnol 2012; 2012: 251364.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 251364
    • Liu, L.1    Li, Y.2    Li, S.3
  • 6
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies-The next generation
    • Metzker ML. Sequencing technologies-The next generation. Nat Rev Genet 2010; 11(1): 31-46.
    • (2010) Nat Rev Genet , vol.11 , Issue.1 , pp. 31-46
    • Metzker, M.L.1
  • 8
    • 0031775443 scopus 로고    scopus 로고
    • The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
    • Matsuda F, Ishii K, Bourvagnet P, et al. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med 1998; 188(11): 2151-62.
    • (1998) J Exp Med , vol.188 , Issue.11 , pp. 2151-2162
    • Matsuda, F.1    Ishii, K.2    Bourvagnet, P.3
  • 9
    • 73949116413 scopus 로고    scopus 로고
    • Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
    • Glanville J, Zhai W, Berka J, et al. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire. Proc Natl Acad Sci USA 2009; 106(48): 20216-21.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.48 , pp. 20216-20221
    • Glanville, J.1    Zhai, W.2    Berka, J.3
  • 10
    • 0024785847 scopus 로고
    • Clonal characterization of the human igg antibody repertoire to haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain v region
    • Scott MG, Crimmins DL, McCourt DW, et al. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region. J Immunol 1989; 143(12): 4110-6.
    • (1989) J Immunol , vol.143 , Issue.12 , pp. 4110-4116
    • Scott, M.G.1    Crimmins, D.L.2    McCourt, D.W.3
  • 11
    • 58149316094 scopus 로고    scopus 로고
    • Imgt, the international immunogenetics information system
    • Database issue
    • Lefranc MP, Giudicelli V, Ginestoux C, et al. IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res 2009; 37(Database issue): D1006-D1012.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1006-1012
    • Lefranc, M.P.1    Giudicelli, V.2    Ginestoux, C.3
  • 12
    • 13444301307 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences
    • Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences. Adv Immunol 2005; 86: 43-112.
    • (2005) Adv Immunol , vol.86 , pp. 43-112
    • Dudley, D.D.1    Chaudhuri, J.2    Bassing, C.H.3    Alt, F.W.4
  • 13
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • Rada C, Ehrenstein MR, Neuberger MS, Milstein C. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 1998; 9(1): 135-41.
    • (1998) Immunity , vol.9 , Issue.1 , pp. 135-141
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 14
    • 0031688707 scopus 로고    scopus 로고
    • Somatic hypermutation of human immunoglobulin heavy chain genes: Targeting of rgyw motifs on both dna strands
    • Dorner T, Foster SJ, Farner NL, Lipsky PE. Somatic hypermutation of human immunoglobulin heavy chain genes: Targeting of RGYW motifs on both DNA strands. Eur J Immunol 1998; 28(10): 3384-96.
    • (1998) Eur J Immunol , vol.28 , Issue.10 , pp. 3384-3396
    • Dorner, T.1    Foster, S.J.2    Farner, N.L.3    Lipsky, P.E.4
  • 15
    • 0344394209 scopus 로고    scopus 로고
    • Development of mouse hybridomas by fusion of myeloma cells with lymphocytes derived from spleen, lymph node, and bone marrow
    • Basalp A, Yucel F. Development of mouse hybridomas by fusion of myeloma cells with lymphocytes derived from spleen, lymph node, and bone marrow. Hybrid Hybridomics 2003; 22(5): 329-31.
    • (2003) Hybrid Hybridomics , vol.22 , Issue.5 , pp. 329-331
    • Basalp, A.1    Yucel, F.2
  • 16
    • 0033230190 scopus 로고    scopus 로고
    • The hybridoma revolution: An offshoot of basic research
    • Milstein C. The hybridoma revolution: An offshoot of basic research. Bioessays 1999; 21(11): 966-73.
    • (1999) Bioessays , vol.21 , Issue.11 , pp. 966-973
    • Milstein, C.1
  • 18
    • 67249138698 scopus 로고    scopus 로고
    • Three decades of human monoclonal antibodies: Past, present and future developments
    • Steinitz M. Three decades of human monoclonal antibodies: Past, present and future developments. Hum Antibodies 2009; 18(1-2): 1-10.
    • (2009) Hum Antibodies , vol.18 , Issue.1-2 , pp. 1-10
    • Steinitz, M.1
  • 19
    • 48649094750 scopus 로고    scopus 로고
    • Fully human antibodies from transgenic mouse and phage display platforms
    • Aug
    • Lonberg N. Fully human antibodies from transgenic mouse and phage display platforms. Curr Opin Immunol 2008 Aug; 20(4): 450-9.
    • (2008) Curr Opin Immunol , vol.20 , Issue.4 , pp. 450-459
    • Lonberg, N.1
  • 20
    • 38449108222 scopus 로고    scopus 로고
    • Human monoclonal antibodies from transgenic mice
    • Lonberg N. Human monoclonal antibodies from transgenic mice. Handb Exp Pharmacol 2008; (181): 69-97.
    • (2008) Handb Exp Pharmacol , vol.181 , pp. 69-97
    • Lonberg, N.1
  • 21
    • 0024780688 scopus 로고
    • Filamentous fusion phage cloning vectors for the study of epitopes and design of vaccines
    • 215-8
    • Parmley SF, Smith GP. Filamentous fusion phage cloning vectors for the study of epitopes and design of vaccines. Adv Exp Med Biol 1989; 251: 215-8: 215-8.
    • (1989) Adv Exp Med Biol , vol.251 , pp. 215-218
    • Parmley, S.F.1    Smith, G.P.2
  • 22
    • 0026233070 scopus 로고
    • Surface presentation of protein epitopes using bacteriophage expression systems
    • Smith GP. Surface presentation of protein epitopes using bacteriophage expression systems. Curr Opin Biotechnol 1991; 2(5): 668-73.
    • (1991) Curr Opin Biotechnol , vol.2 , Issue.5 , pp. 668-673
    • Smith, G.P.1
  • 23
    • 0027008592 scopus 로고
    • Phage display technology in antibody engineering: Design of phagemid vectors and in vitro maturation systems
    • Soderlind E, Simonsson AC, Borrebaeck CA. Phage display technology in antibody engineering: Design of phagemid vectors and in vitro maturation systems. Immunol Rev 1992; 130: 109-24.
    • (1992) Immunol Rev , vol.130 , pp. 109-124
    • Soderlind, E.1    Simonsson, A.C.2    Borrebaeck, C.A.3
  • 24
    • 0036366705 scopus 로고    scopus 로고
    • Overview of antibody phage-display technology and its applications
    • Hoogenboom HR. Overview of antibody phage-display technology and its applications. Methods Mol Biol 2002; 178: 1-37.
    • (2002) Methods Mol Biol , vol.178 , pp. 1-37
    • Hoogenboom, H.R.1
  • 25
    • 84857642791 scopus 로고    scopus 로고
    • Phagemid vectors for phage display: Properties, characteristics and construction
    • Qi H, Lu H, Qiu HJ, Petrenko V, Liu A. Phagemid vectors for phage display: Properties, characteristics and construction. J Mol Biol 2012; 417(3): 129-43.
    • (2012) J Mol Biol , vol.417 , Issue.3 , pp. 129-143
    • Qi, H.1    Lu, H.2    Qiu, H.J.3    Petrenko, V.4    Liu, A.5
  • 26
    • 84859709933 scopus 로고    scopus 로고
    • Phage display screening without repetitious selection rounds
    • 't Hoen PA, Jirka SM, Ten Broeke BR, et al. Phage display screening without repetitious selection rounds. Anal Biochem 2012; 421(2): 622-31.
    • (2012) Anal Biochem , vol.421 , Issue.2 , pp. 622-631
    • Thoen, P.A.1    Jirka, S.M.2    Ten Broeke, B.R.3
  • 27
    • 34248136998 scopus 로고    scopus 로고
    • Design of synthetic antibody libraries
    • Benhar I. Design of synthetic antibody libraries. Expert Opin Biol Ther 2007; 7(5): 763-79.
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.5 , pp. 763-779
    • Benhar, I.1
  • 28
    • 84858033688 scopus 로고    scopus 로고
    • Molecular considerations for development of phage antibody libraries
    • Apr
    • Tohidkia MR, Barar J, Asadi F, Omidi Y. Molecular considerations for development of phage antibody libraries. J Drug Target 2012 Apr; 20(3): 195-208.
    • (2012) J Drug Target , vol.20 , Issue.3 , pp. 195-208
    • Tohidkia, M.R.1    Barar, J.2    Asadi, F.3    Omidi, Y.4
  • 29
    • 79251472471 scopus 로고    scopus 로고
    • Phage display for the generation of antibodies for proteome research diagnostics and therapy
    • Schirrmann T, Meyer T, Schutte M, Frenzel A, Hust M. Phage display for the generation of antibodies for proteome research, diagnostics and therapy. Molecules 2011; 16(1): 412-26.
    • (2011) Molecules , vol.16 , Issue.1 , pp. 412-426
    • Schirrmann, T.1    Meyer, T.2    Schutte, M.3    Frenzel, A.4    Hust, M.5
  • 30
    • 79957617682 scopus 로고    scopus 로고
    • High affinity developability and functional size: The holy grail of combinatorial antibody library generation
    • Ponsel D, Neugebauer J, Ladetzki-Baehs K, Tissot K. High affinity, developability and functional size: The holy grail of combinatorial antibody library generation. Molecules 2011; 16(5): 3675-700.
    • (2011) Molecules , vol.16 , Issue.5 , pp. 3675-3700
    • Ponsel, D.1    Neugebauer, J.2    Ladetzki-Baehs, K.3    Tissot, K.4
  • 31
    • 37549055446 scopus 로고    scopus 로고
    • Human monoclonal antibodies by immortalization of memory B cells
    • Lanzavecchia A, Corti D, Sallusto F. Human monoclonal antibodies by immortalization of memory B cells. Curr Opin Biotechnol 2007; 18(6): 523-8.
    • (2007) Curr Opin Biotechnol , vol.18 , Issue.6 , pp. 523-528
    • Lanzavecchia, A.1    Corti, D.2    Sallusto, F.3
  • 33
    • 4043154176 scopus 로고    scopus 로고
    • An efficient method to make human monoclonal antibodies from memory B cells: Potent neutralization of SARS coronavirus
    • Traggiai E, Becker S, Subbarao K, et al. An efficient method to make human monoclonal antibodies from memory B cells: Potent neutralization of SARS coronavirus. Nat Med 2004; 10(8): 871-5.
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 871-875
    • Traggiai, E.1    Becker, S.2    Subbarao, K.3
  • 34
    • 79952714838 scopus 로고    scopus 로고
    • A novel platform to produce human monoclonal antibodies: The next generation of therapeutic human monoclonal antibodies discovery
    • Duvall M, Bradley N, Fiorini RN. A novel platform to produce human monoclonal antibodies: The next generation of therapeutic human monoclonal antibodies discovery. MAbs 2011; 3(2): 203-8.
    • (2011) MAbs , vol.3 , Issue.2 , pp. 203-208
    • Duvall, M.1    Bradley, N.2    Fiorini, R.N.3
  • 35
    • 43249114364 scopus 로고    scopus 로고
    • Conditional immortalization of human B cells by CD40 ligation
    • Wiesner M, Zentz C, Mayr C, et al. Conditional immortalization of human B cells by CD40 ligation. PLoS One 2008; 3(1): E1464.
    • (2008) PLoS One , vol.3 , Issue.1
    • Wiesner, M.1    Zentz, C.2    Mayr, C.3
  • 36
    • 73849116425 scopus 로고    scopus 로고
    • Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming
    • Kwakkenbos MJ, Diehl SA, Yasuda E, et al. Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming. Nat Med 2010; 16(1): 123-8.
    • (2010) Nat Med , vol.16 , Issue.1 , pp. 123-128
    • Kwakkenbos, M.J.1    Diehl, S.A.2    Yasuda, E.3
  • 37
    • 0032973937 scopus 로고    scopus 로고
    • Bcl2 and v-abl oncogenes cooperate to immortalize murine B cells that secrete antigen specific antibodies
    • Kumar A, Ta D, Henderson D, et al. bcl2 and v-abl oncogenes cooperate to immortalize murine B cells that secrete antigen specific antibodies. Immunol Lett 1999; 65(3): 153-9.
    • (1999) Immunol Lett , vol.65 , Issue.3 , pp. 153-159
    • Kumar, A.1    Ta, D.2    Henderson, D.3
  • 38
    • 80053438075 scopus 로고    scopus 로고
    • Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latencyassociated nuclear antigen
    • Liang X, Paden CR, Morales FM, Powers RP, Jacob J, Speck SH. Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latencyassociated nuclear antigen. PLoS Pathog 2011; 7(9): E1002220.
    • (2011) PLoS Pathog , vol.7 , Issue.9
    • Liang, X.1    Paden, C.R.2    Morales, F.M.3    Powers, R.P.4    Jacob, J.5    Speck, S.H.6
  • 39
    • 80052247304 scopus 로고    scopus 로고
    • Harnessing the immune system's arsenal: Producing human monoclonal antibodies for therapeutics and investigating immune responses
    • Sullivan M, Kaur K, Pauli N, Wilson PC. Harnessing the immune system's arsenal: Producing human monoclonal antibodies for therapeutics and investigating immune responses. F1000 Biol Rep 2011; 3: 17.
    • (2011) F1000 Biol Rep , vol.3 , pp. 17
    • Sullivan, M.1    Kaur, K.2    Pauli, N.3    Wilson, P.C.4
  • 40
    • 79958835059 scopus 로고    scopus 로고
    • Comprehensive next-generation cancer genome sequencing in the era of targeted therapy and personalized oncology
    • Cronin M, Ross JS. Comprehensive next-generation cancer genome sequencing in the era of targeted therapy and personalized oncology. Biomark Med 2011; 5(3): 293-305.
    • (2011) Biomark Med , vol.5 , Issue.3 , pp. 293-305
    • Cronin, M.1    Ross, J.S.2
  • 41
    • 84860756398 scopus 로고    scopus 로고
    • Performance comparison of benchtop high-throughput sequencing platforms
    • Loman NJ, Misra RV, Dallman TJ, et al. Performance comparison of benchtop high-throughput sequencing platforms. Nat Biotechnol 2012; 30(5): 434-9.
    • (2012) Nat Biotechnol , vol.30 , Issue.5 , pp. 434-439
    • Loman, N.J.1    Misra, R.V.2    Dallman, T.J.3
  • 42
    • 84856185049 scopus 로고    scopus 로고
    • Rep-Seq: Uncovering the immunological repertoire through next-generation sequencing
    • Benichou J, Ben-Hamo R, Louzoun Y, Efroni S. Rep-Seq: Uncovering the immunological repertoire through next-generation sequencing. Immunology 2012; 135(3): 183-91.
    • (2012) Immunology , vol.135 , Issue.3 , pp. 183-191
    • Benichou, J.1    Ben-Hamo, R.2    Louzoun, Y.3    Efroni, S.4
  • 43
    • 79961160227 scopus 로고    scopus 로고
    • High-resolution description of antibody heavy-chain repertoires in humans
    • Arnaout R, Lee W, Cahill P, et al. High-resolution description of antibody heavy-chain repertoires in humans. PLoS One 2011; 6(8): E22365.
    • (2011) PLoS One , vol.6 , Issue.8
    • Arnaout, R.1    Lee, W.2    Cahill, P.3
  • 44
    • 84864762364 scopus 로고    scopus 로고
    • Frequency and genetic characterization of V(DD J recombinants in the human peripheral blood antibody repertoire
    • Briney BS, Willis JR, Hicar MD, Thomas JW, Crowe JE, Jr. Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire. Immunology 2012; 137(1): 56-64.
    • (2012) Immunology , vol.137 , Issue.1 , pp. 56-64
    • Briney, B.S.1    Willis, J.R.2    Hicar, M.D.3    Thomas, J.W.4    Crowe Jr., J.E.5
  • 45
    • 78651390679 scopus 로고    scopus 로고
    • Sequencing antibody repertoires: The next generation
    • Fischer N. Sequencing antibody repertoires: The next generation. MAbs 2011; 3(1): 17-20.
    • (2011) MAbs , vol.3 , Issue.1 , pp. 17-20
    • Fischer, N.1
  • 46
    • 84866177970 scopus 로고    scopus 로고
    • Shaping of human germline igh repertoires revealed by deep sequencing
    • Larimore K, McCormick MW, Robins HS, Greenberg PD. Shaping of Human Germline IgH Repertoires Revealed by Deep Sequencing. J Immunol 2012; 189(6): 3221-30.
    • (2012) J Immunol , vol.189 , Issue.6 , pp. 3221-3230
    • Larimore, K.1    McCormick, M.W.2    Robins, H.S.3    Greenberg, P.D.4
  • 47
    • 65649122270 scopus 로고    scopus 로고
    • Highthroughput sequencing of the zebrafish antibody repertoire
    • Weinstein JA, Jiang N, White RA, III, Fisher DS, Quake SR. Highthroughput sequencing of the zebrafish antibody repertoire. Science 2009; 324(5928): 807-10.
    • (2009) Science , vol.324 , Issue.5928 , pp. 807-810
    • Weinstein, J.A.1    Jiang, N.2    White III, R.A.3    Fisher, D.S.4    Quake, S.R.5
  • 48
    • 0030479971 scopus 로고    scopus 로고
    • The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation
    • Kohsaka H, Carson DA, Rassenti LZ, et al. The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation. J Clin Invest 1996; 98(12): 2794-800.
    • (1996) J Clin Invest , vol.98 , Issue.12 , pp. 2794-2800
    • Kohsaka, H.1    Carson, D.A.2    Rassenti, L.Z.3
  • 49
    • 77956688921 scopus 로고    scopus 로고
    • Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells
    • Reddy ST, Ge X, Miklos AE, et al. Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat Biotechnol 2010; 28(9): 965-9.
    • (2010) Nat Biotechnol , vol.28 , Issue.9 , pp. 965-969
    • Reddy, S.T.1    Ge, X.2    Miklos, A.E.3
  • 50
    • 17444395195 scopus 로고    scopus 로고
    • Production of recombinant Ig molecules from antigen-selected single B cells and restricted usage of Ig-gene segments by anti-D antibodies
    • Dohmen SE, Mulder A, Verhagen OJ, Eijsink C, Franke-van Dijk ME, van der Schoot CE. Production of recombinant Ig molecules from antigen-selected single B cells and restricted usage of Ig-gene segments by anti-D antibodies. J Immunol Methods 2005; 298(1-2): 9-20.
    • (2005) J Immunol Methods , vol.298 , Issue.1-2 , pp. 9-20
    • Dohmen, S.E.1    Mulder, A.2    Verhagen, O.J.3    Eijsink, C.4    Franke-Van Dijk, M.E.5    Van Der Schoot, C.E.6
  • 51
    • 79952169637 scopus 로고    scopus 로고
    • Diversity of phage-displayed libraries of peptides during panning and amplification
    • Derda R, Tang SK, Li SC, Ng S, Matochko W, Jafari MR. Diversity of phage-displayed libraries of peptides during panning and amplification. Molecules 2011; 16(2): 1776-803.
    • (2011) Molecules , vol.16 , Issue.2 , pp. 1776-1803
    • Derda, R.1    Tang, S.K.2    Li, S.C.3    Ng, S.4    Matochko, W.5    Jafari, M.R.6
  • 52
    • 84868344832 scopus 로고    scopus 로고
    • Deep sequencing analysis of phage libraries using Illumina platform
    • 12 10
    • Matochko WL, Chu K, Jin B, Lee SW, Whitesides GM, Derda R. Deep sequencing analysis of phage libraries using Illumina platform. Methods 2012; %20. pii: S1046-2023(12): 10.
    • (2012) Methods , vol.20 , pp. 1046-2023
    • Matochko, W.L.1    Chu, K.2    Jin, B.3    Lee, S.W.4    Whitesides, G.M.5    Derda, R.6
  • 53
    • 78649893449 scopus 로고    scopus 로고
    • By-passing in vitro screening-next generation sequencing technologies applied to antibody display and in silico candidate selection
    • Ravn U, Gueneau F, Baerlocher L, et al. By-passing in vitro screening-next generation sequencing technologies applied to antibody display and in silico candidate selection. Nucleic Acids Res 2010; 38(21): E193.
    • (2010) Nucleic Acids Res , vol.38 , Issue.21
    • Ravn, U.1    Gueneau, F.2    Baerlocher, L.3
  • 54
    • 84866631715 scopus 로고    scopus 로고
    • Transferring the characteristics of naturally occurring and biased antibody repertoires to human antibody libraries by trapping cdrh3 sequences
    • Venet S, Ravn U, Buatois V, et al. Transferring the Characteristics of Naturally Occurring and Biased Antibody Repertoires to Human Antibody Libraries by Trapping CDRH3 Sequences. PLoS One 2012; 7(8): E43471.
    • (2012) PLoS One , vol.7 , Issue.8
    • Venet, S.1    Ravn, U.2    Buatois, V.3
  • 55
    • 84877142458 scopus 로고    scopus 로고
    • Deep sequencing of phage display libraries to support antibody discovery
    • Ravn U, Didelot G, Venet S, et al. Deep sequencing of phage display libraries to support antibody discovery. Methods 2013; 60(1): 99-110.
    • (2013) Methods , vol.60 , Issue.1 , pp. 99-110
    • Ravn, U.1    Didelot, G.2    Venet, S.3


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