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Volumn 5, Issue APR, 2014, Pages

Receptor pre-clustering and T cell responses: Insights into molecular mechanisms

Author keywords

Clustering; Memory T cells; Naive T cells; Signaling; Stochastic dynamics; T cell receptor

Indexed keywords

T LYMPHOCYTE RECEPTOR;

EID: 84900850315     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00132     Document Type: Article
Times cited : (24)

References (69)
  • 1
    • 0346244099 scopus 로고    scopus 로고
    • T-cell-antigen recognition and the immunological synapse
    • doi: 10.1038/nri1245
    • Huppa JB, Davis MM. T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol (2003) 3(12):973-83. doi: 10.1038/nri1245.
    • (2003) Nat Rev Immunol , vol.3 , Issue.12 , pp. 973-983
    • Huppa, J.B.1    Davis, M.M.2
  • 2
    • 84871436412 scopus 로고    scopus 로고
    • Cell: cell interactions in the immune system
    • doi:10.1111/imr.12025
    • Batista FD, Dustin ML. Cell: cell interactions in the immune system. Immunol Rev (2013) 251(1):7-12. doi:10.1111/imr.12025.
    • (2013) Immunol Rev , vol.251 , Issue.1 , pp. 7-12
    • Batista, F.D.1    Dustin, M.L.2
  • 3
    • 84871424424 scopus 로고    scopus 로고
    • Organization of the resting TCR in nanoscale oligomers
    • doi:10.1111/imr.12019
    • Schamel WW, Alarcón B. Organization of the resting TCR in nanoscale oligomers. Immunol Rev (2013) 251(1):13-20. doi:10.1111/imr.12019.
    • (2013) Immunol Rev , vol.251 , Issue.1 , pp. 13-20
    • Schamel, W.W.1    Alarcón, B.2
  • 4
    • 84858759719 scopus 로고    scopus 로고
    • Mechanical modulation of receptor-ligand interactions at cell-cell interfaces
    • doi:10.1016/j.bpj.2012.02.006
    • Allard JF, Dushek O, Coombs D, van der Merwe PA. Mechanical modulation of receptor-ligand interactions at cell-cell interfaces. Biophys J (2012) 102(6):1265-73. doi:10.1016/j.bpj.2012.02.006.
    • (2012) Biophys J , vol.102 , Issue.6 , pp. 1265-1273
    • Allard, J.F.1    Dushek, O.2    Coombs, D.3    van der Merwe, P.A.4
  • 5
    • 74049157769 scopus 로고    scopus 로고
    • TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
    • doi:10.1038/ni.1832
    • Lillemeier BF, Mörtelmaier MA, Forstner MB, Huppa JB, Groves JT, Davis MM. TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nat Immunol (2009) 11(1):90-6. doi:10.1038/ni.1832.
    • (2009) Nat Immunol , vol.11 , Issue.1 , pp. 90-96
    • Lillemeier, B.F.1    Mörtelmaier, M.A.2    Forstner, M.B.3    Huppa, J.B.4    Groves, J.T.5    Davis, M.M.6
  • 6
    • 84867413102 scopus 로고    scopus 로고
    • Insights into t cell recognition of antigen: significance of two-dimensional kinetic parameters
    • doi:10.3389/fimmu.2012.00086
    • Edwards LJ, Zarnitsyna VI, Hood JD, Evavold BD, Zhu C. Insights into t cell recognition of antigen: significance of two-dimensional kinetic parameters. Front Immunol (2012) 3:86. doi:10.3389/fimmu.2012.00086.
    • (2012) Front Immunol , vol.3 , pp. 86
    • Edwards, L.J.1    Zarnitsyna, V.I.2    Hood, J.D.3    Evavold, B.D.4    Zhu, C.5
  • 7
    • 84864939833 scopus 로고    scopus 로고
    • T cell triggering: insights from 2D kinetics analysis of molecular interactions
    • doi:10.1088/1478-3975/9/4/045005
    • Zarnitsyna V, Zhu C. T cell triggering: insights from 2D kinetics analysis of molecular interactions. Phys Biol (2012) 9(4):045005. doi:10.1088/1478-3975/9/4/045005.
    • (2012) Phys Biol , vol.9 , Issue.4 , pp. 045005
    • Zarnitsyna, V.1    Zhu, C.2
  • 8
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • doi:10.1073/pnas.92.11.5042
    • McKeithan T. Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci U S A (1995) 92(11):5042. doi:10.1073/pnas.92.11.5042.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.11 , pp. 5042
    • McKeithan, T.1
  • 9
    • 0035286588 scopus 로고    scopus 로고
    • Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
    • doi:10.1038/85286
    • Kalergis AM, Boucheron N, Doucey M-A, Palmieri E, Goyarts EC, Vegh Z, et al. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat Immunol (2001) 2(3):229-34. doi:10.1038/85286.
    • (2001) Nat Immunol , vol.2 , Issue.3 , pp. 229-234
    • Kalergis, A.M.1    Boucheron, N.2    Doucey, M.-A.3    Palmieri, E.4    Goyarts, E.C.5    Vegh, Z.6
  • 10
    • 0000242251 scopus 로고
    • Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and IA molecules
    • doi:10.1073/pnas.80.19.6019
    • Matis LA, Glimcher LH, Paul WE, Schwartz RH. Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and IA molecules. Proc Natl Acad Sci U S A (1983) 80(19):6019-23. doi:10.1073/pnas.80.19.6019.
    • (1983) Proc Natl Acad Sci U S A , vol.80 , Issue.19 , pp. 6019-6023
    • Matis, L.A.1    Glimcher, L.H.2    Paul, W.E.3    Schwartz, R.H.4
  • 11
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide MHC complexes
    • doi:10.1038/375148a0
    • Valitutti S, Müller S, Cella M, Padovan E, Lanzavecchia A. Serial triggering of many T-cell receptors by a few peptide MHC complexes. Nature (1995) 375(6527):148-51. doi:10.1038/375148a0.
    • (1995) Nature , vol.375 , Issue.6527 , pp. 148-151
    • Valitutti, S.1    Müller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 12
    • 0034925767 scopus 로고    scopus 로고
    • Interaction of T cells with APCS: the serial encounter model
    • doi:10.1016/S1471-4906(01)01869-5
    • Friedl P, Gunzer M. Interaction of T cells with APCS: the serial encounter model. Trends Immunol (2001) 22(4):187-91. doi:10.1016/S1471-4906(01)01869-5.
    • (2001) Trends Immunol , vol.22 , Issue.4 , pp. 187-191
    • Friedl, P.1    Gunzer, M.2
  • 13
    • 73449105773 scopus 로고    scopus 로고
    • A role for rebinding in rapid and reliable T cell responses to antigen
    • doi:10.1371/journal.pcbi.1000578
    • Dushek O, Das R, Coombs D. A role for rebinding in rapid and reliable T cell responses to antigen. PLoS Comput Biol (2009) 5(11):e1000578. doi:10.1371/journal.pcbi.1000578.
    • (2009) PLoS Comput Biol , vol.5 , Issue.11
    • Dushek, O.1    Das, R.2    Coombs, D.3
  • 14
    • 33845607123 scopus 로고    scopus 로고
    • Thymic selection threshold defined by compartmentalization of RAS/MAPK signalling
    • doi:10.1038/nature05269
    • Daniels MA, Teixeiro E, Gill J, Hausmann B, Roubaty D, Holmberg K, et al. Thymic selection threshold defined by compartmentalization of RAS/MAPK signalling. Nature (2006) 444(7120):724-9. doi:10.1038/nature05269.
    • (2006) Nature , vol.444 , Issue.7120 , pp. 724-729
    • Daniels, M.A.1    Teixeiro, E.2    Gill, J.3    Hausmann, B.4    Roubaty, D.5    Holmberg, K.6
  • 15
    • 78649855808 scopus 로고    scopus 로고
    • The space and time frames of T cell activation at the immunological synapse
    • doi:10.1016/j.febslet.2010.10.010
    • Valitutti S, Coombs D, Dupré L. The space and time frames of T cell activation at the immunological synapse. FEBS Lett (2010) 584(24):4851-7. doi:10.1016/j.febslet.2010.10.010.
    • (2010) FEBS Lett , vol.584 , Issue.24 , pp. 4851-4857
    • Valitutti, S.1    Coombs, D.2    Dupré, L.3
  • 17
    • 80053132781 scopus 로고    scopus 로고
    • Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes
    • doi:10.1016/j.immuni.2011.08.010
    • Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, et al. Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes. Immunity (2011) 35(3):375-87. doi:10.1016/j.immuni.2011.08.010.
    • (2011) Immunity , vol.35 , Issue.3 , pp. 375-387
    • Kumar, R.1    Ferez, M.2    Swamy, M.3    Arechaga, I.4    Rejas, M.T.5    Valpuesta, J.M.6
  • 18
    • 23944469458 scopus 로고    scopus 로고
    • Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response
    • doi:10.1084/jem.20042155
    • Schamel WW, Arechaga I, Risueño RM, van Santen HM, Cabezas P, Risco C, et al. Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. J Exp Med (2005) 202(4):493-503. doi:10.1084/jem.20042155.
    • (2005) J Exp Med , vol.202 , Issue.4 , pp. 493-503
    • Schamel, W.W.1    Arechaga, I.2    Risueño, R.M.3    van Santen, H.M.4    Cabezas, P.5    Risco, C.6
  • 19
    • 84866544100 scopus 로고    scopus 로고
    • Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters
    • doi:10.1073/pnas.1208696109
    • Lu X, Gibbs JS, Hickman HD, David A, Dolan BP, Jin Y, et al. Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters. Proc Natl Acad Sci U S A (2012) 109(38):15407-12. doi:10.1073/pnas.1208696109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.38 , pp. 15407-15412
    • Lu, X.1    Gibbs, J.S.2    Hickman, H.D.3    David, A.4    Dolan, B.P.5    Jin, Y.6
  • 20
    • 84891109254 scopus 로고    scopus 로고
    • Cognate peptide-MHC complexes are expressed as tightly apposed nanoclusters in virus-infected cells to allow tcr crosslinking
    • doi:10.4049/jimmunol.1301224
    • Ferez M, Castro M, Alarcon B, van Santen HM. Cognate peptide-MHC complexes are expressed as tightly apposed nanoclusters in virus-infected cells to allow tcr crosslinking. J Immunol (2014) 192(1):52-8. doi:10.4049/jimmunol.1301224.
    • (2014) J Immunol , vol.192 , Issue.1 , pp. 52-58
    • Ferez, M.1    Castro, M.2    Alarcon, B.3    van Santen, H.M.4
  • 21
    • 84877723637 scopus 로고    scopus 로고
    • Major histocompatibility complex (MHC) class II-peptide complexes arrive at the plasma membrane in cholesterol-rich microclusters
    • doi:10.1074/jbc.M112.442640
    • Bosch B, Heipertz EL, Drake JR, Roche PA. Major histocompatibility complex (MHC) class II-peptide complexes arrive at the plasma membrane in cholesterol-rich microclusters. J Biol Chem (2013) 288(19):13236-42. doi:10.1074/jbc.M112.442640.
    • (2013) J Biol Chem , vol.288 , Issue.19 , pp. 13236-13242
    • Bosch, B.1    Heipertz, E.L.2    Drake, J.R.3    Roche, P.A.4
  • 22
    • 2942588906 scopus 로고    scopus 로고
    • Mathematical and computational models of immune-receptor signalling
    • doi:10.1038/nri1374
    • Goldstein B, Faeder JR, Hlavacek WS. Mathematical and computational models of immune-receptor signalling. Nat Rev Immunol (2004) 4(6):445-56. doi:10.1038/nri1374.
    • (2004) Nat Rev Immunol , vol.4 , Issue.6 , pp. 445-456
    • Goldstein, B.1    Faeder, J.R.2    Hlavacek, W.S.3
  • 23
    • 33745223518 scopus 로고    scopus 로고
    • T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity
    • doi:10.1038/sj.embor.7400682
    • Alarcón B, Swamy M, van Santen HM, Schamel WW. T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity. EMBO Rep (2006) 7(5):490-5. doi:10.1038/sj.embor.7400682.
    • (2006) EMBO Rep , vol.7 , Issue.5 , pp. 490-495
    • Alarcón, B.1    Swamy, M.2    van Santen, H.M.3    Schamel, W.W.4
  • 24
    • 0032492852 scopus 로고    scopus 로고
    • Receptor clustering as a cellular mechanism to control sensitivity
    • doi:10.1038/30018
    • Bray D, Levin MD, Morton-Firth CJ. Receptor clustering as a cellular mechanism to control sensitivity. Nature (1998) 393(6680):85-8. doi:10.1038/30018.
    • (1998) Nature , vol.393 , Issue.6680 , pp. 85-88
    • Bray, D.1    Levin, M.D.2    Morton-Firth, C.J.3
  • 25
    • 0034889233 scopus 로고    scopus 로고
    • + T cells without selection of higher affinity TCR
    • doi:10.1038/90650
    • + T cells without selection of higher affinity TCR. Nat Immunol (2001) 2(8):711-7. doi:10.1038/90650.
    • (2001) Nat Immunol , vol.2 , Issue.8 , pp. 711-717
    • Slifka, M.K.1    Whitton, J.L.2
  • 27
    • 78650599246 scopus 로고    scopus 로고
    • Mechanisms for T cell receptor triggering
    • doi:10.1038/nri2887
    • van der Merwe P, Dushek O. Mechanisms for T cell receptor triggering. Nat Rev Immunol (2010) 11(1):47-55. doi:10.1038/nri2887.
    • (2010) Nat Rev Immunol , vol.11 , Issue.1 , pp. 47-55
    • van der Merwe, P.1    Dushek, O.2
  • 28
    • 82455192402 scopus 로고    scopus 로고
    • Drips solidify: progress in understanding endogenous MHC class I antigen processing
    • doi:10.1016/j.it.2011.08.001
    • Yewdell JW. Drips solidify: progress in understanding endogenous MHC class I antigen processing. Trends Immunol (2011) 32(11):548-58. doi:10.1016/j.it.2011.08.001.
    • (2011) Trends Immunol , vol.32 , Issue.11 , pp. 548-558
    • Yewdell, J.W.1
  • 30
    • 84899883247 scopus 로고    scopus 로고
    • Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors
    • doi:10.1189/jlb.1113599.
    • Antón LC, Yewdell JW. Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors. J Leukoc Biol (2014). doi:10.1189/jlb.1113599.
    • (2014) J Leukoc Biol
    • Antón, L.C.1    Yewdell, J.W.2
  • 31
    • 0034753172 scopus 로고    scopus 로고
    • T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model
    • doi:10.1016/S0006-3495(01)75899-7
    • Stone J, Cochran J, Stern L. T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model. Biophys J (2001) 81(5):2547-57. doi:10.1016/S0006-3495(01)75899-7.
    • (2001) Biophys J , vol.81 , Issue.5 , pp. 2547-2557
    • Stone, J.1    Cochran, J.2    Stern, L.3
  • 32
    • 58149280299 scopus 로고    scopus 로고
    • T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity
    • doi:10.1111/j.1365-2567.2008.03015.x
    • Stone J, Chervin A, Kranz D. T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. Immunology (2009) 126(2):165-76. doi:10.1111/j.1365-2567.2008.03015.x.
    • (2009) Immunology , vol.126 , Issue.2 , pp. 165-176
    • Stone, J.1    Chervin, A.2    Kranz, D.3
  • 33
    • 84874216929 scopus 로고    scopus 로고
    • A review of mathematical models for T cell receptor triggering and antigen discrimination
    • Molina-París C, Lythe G, editors. New York: Springer
    • Coombs D, Dushek O, Merwe P. A review of mathematical models for T cell receptor triggering and antigen discrimination. In: Molina-París C, Lythe G, editors. Mathematical Models and Immune Cell Biology. New York: Springer (2011). p. 25-45.
    • (2011) Mathematical Models and Immune Cell Biology , pp. 25-45
    • Coombs, D.1    Dushek, O.2    Merwe, P.3
  • 34
    • 0036795530 scopus 로고    scopus 로고
    • Activated TCRs remain marked for internalization after dissociation from pMHC
    • doi:10.1038/ni838
    • Coombs D, Kalergis AM, Nathenson SG, Wofsy C, Goldstein B. Activated TCRs remain marked for internalization after dissociation from pMHC. Nat Immunol (2002) 3(10):926-31. doi:10.1038/ni838.
    • (2002) Nat Immunol , vol.3 , Issue.10 , pp. 926-931
    • Coombs, D.1    Kalergis, A.M.2    Nathenson, S.G.3    Wofsy, C.4    Goldstein, B.5
  • 35
    • 78649812470 scopus 로고    scopus 로고
    • Signaling microdomains in T cells
    • doi:10.1016/j.febslet.2010.10.015
    • Choudhuri K, Dustin ML. Signaling microdomains in T cells. FEBS Lett (2010) 584(24):4823-31. doi:10.1016/j.febslet.2010.10.015.
    • (2010) FEBS Lett , vol.584 , Issue.24 , pp. 4823-4831
    • Choudhuri, K.1    Dustin, M.L.2
  • 36
    • 77950881648 scopus 로고    scopus 로고
    • The immunological synapse, TCR microclusters, and T cell activation
    • Saito T, Batista FD, editors. Berlin Heidelberg: Springer
    • Yokosuka T, Saito T. The immunological synapse, TCR microclusters, and T cell activation. In: Saito T, Batista FD, editors. Immunological Synapse. Berlin Heidelberg: Springer (2010). p. 81-107.
    • (2010) Immunological Synapse , pp. 81-107
    • Yokosuka, T.1    Saito, T.2
  • 37
    • 0036293994 scopus 로고    scopus 로고
    • Multiple site-specific infrared dichroism of CD3-ζ, a transmembrane helix bundle
    • doi:10.1006/jmbi.2001.5267
    • Torres J, Briggs JA, Arkin IT. Multiple site-specific infrared dichroism of CD3-ζ, a transmembrane helix bundle. J Mol Biol (2002) 316(2):365-74. doi:10.1006/jmbi.2001.5267.
    • (2002) J Mol Biol , vol.316 , Issue.2 , pp. 365-374
    • Torres, J.1    Briggs, J.A.2    Arkin, I.T.3
  • 39
    • 0003781238 scopus 로고    scopus 로고
    • Cambridge University Press
    • Norris JR. Markov Chains. Cambridge University Press (1998).
    • (1998) Markov Chains
    • Norris, J.R.1
  • 41
    • 0028913816 scopus 로고
    • Ligands for the T-cell receptor: hard times for avidity models
    • doi:10.1016/0167-5699(95)80163-4
    • Janeway CA Jr. Ligands for the T-cell receptor: hard times for avidity models. Immunol Today (1995) 16(5):223-5. doi:10.1016/0167-5699(95)80163-4.
    • (1995) Immunol Today , vol.16 , Issue.5 , pp. 223-225
    • Janeway Jr., C.A.1
  • 42
    • 40149108609 scopus 로고    scopus 로고
    • Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    • doi:10.1371/journal.pbio.0060043
    • Ma Z, Sharp KA, Janmey PA, Finkel TH. Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity. PLoS Biol (2008) 6(2):e43. doi:10.1371/journal.pbio.0060043.
    • (2008) PLoS Biol , vol.6 , Issue.2
    • Ma, Z.1    Sharp, K.A.2    Janmey, P.A.3    Finkel, T.H.4
  • 44
    • 83755178630 scopus 로고    scopus 로고
    • Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs
    • doi:10.4049/jimmunol.1101734
    • Stone J, Artyomov M, Chervin A, Chakraborty A, Eisen H, Kranz D. Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs. J Immunol (2011) 187(12):6281-90. doi:10.4049/jimmunol.1101734.
    • (2011) J Immunol , vol.187 , Issue.12 , pp. 6281-6290
    • Stone, J.1    Artyomov, M.2    Chervin, A.3    Chakraborty, A.4    Eisen, H.5    Kranz, D.6
  • 45
    • 0029100015 scopus 로고
    • Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness
    • doi:10.1084/jem.182.2.439
    • Abastado J-P, Lone Y-C, Casrouge A, Boulot G, Kourilsky P. Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness. J Exp Med (1995) 182(2):439-47. doi:10.1084/jem.182.2.439.
    • (1995) J Exp Med , vol.182 , Issue.2 , pp. 439-447
    • Abastado, J.-P.1    Lone, Y.-C.2    Casrouge, A.3    Boulot, G.4    Kourilsky, P.5
  • 46
    • 0033710093 scopus 로고    scopus 로고
    • The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
    • doi:10.1016/S1074-7613(00)80177-6
    • Cochran JR, Cameron TO, Stern LJ. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity (2000) 12(3):241-50. doi:10.1016/S1074-7613(00)80177-6.
    • (2000) Immunity , vol.12 , Issue.3 , pp. 241-250
    • Cochran, J.R.1    Cameron, T.O.2    Stern, L.J.3
  • 47
    • 0032192469 scopus 로고    scopus 로고
    • Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands
    • doi:10.1016/S1074-7613(00)80629-9
    • Boniface JJ, Rabinowitz JD, Wülfing C, Hampl J, Reich Z, Altman JD, et al. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity (1998) 9(4):459-66. doi:10.1016/S1074-7613(00)80629-9.
    • (1998) Immunity , vol.9 , Issue.4 , pp. 459-466
    • Boniface, J.J.1    Rabinowitz, J.D.2    Wülfing, C.3    Hampl, J.4    Reich, Z.5    Altman, J.D.6
  • 48
    • 61349149901 scopus 로고    scopus 로고
    • Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
    • doi:10.1038/nri2469
    • Palmer E, Naeher D. Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat Rev Immunol (2009) 9(3):207-13. doi:10.1038/nri2469.
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 207-213
    • Palmer, E.1    Naeher, D.2
  • 49
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical reactions
    • doi:10.1021/j100540a008
    • Gillespie D. Exact stochastic simulation of coupled chemical reactions. J Phys Chem (1977) 81:2340-61. doi:10.1021/j100540a008.
    • (1977) J Phys Chem , vol.81 , pp. 2340-2361
    • Gillespie, D.1
  • 50
    • 33747813547 scopus 로고    scopus 로고
    • Differential partitioning and trafficking of GM gangliosides and cholesterol-rich lipid rafts in thymic and splenic CD4 T cells
    • doi:10.1016/j.molimm.2006.02.008
    • Brumeanu T-D, Preda-Pais A, Stoica C, Bona C, Casares S. Differential partitioning and trafficking of GM gangliosides and cholesterol-rich lipid rafts in thymic and splenic CD4 T cells. Mol Immunol (2007) 44(4):530-40. doi:10.1016/j.molimm.2006.02.008.
    • (2007) Mol Immunol , vol.44 , Issue.4 , pp. 530-540
    • Brumeanu, T.-D.1    Preda-Pais, A.2    Stoica, C.3    Bona, C.4    Casares, S.5
  • 52
    • 74849118341 scopus 로고    scopus 로고
    • Lipid rafts as a membrane-organizing principle
    • doi:10.1126/science.1174621
    • Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science (2010) 327(5961):46-50. doi:10.1126/science.1174621.
    • (2010) Science , vol.327 , Issue.5961 , pp. 46-50
    • Lingwood, D.1    Simons, K.2
  • 53
    • 84856020544 scopus 로고    scopus 로고
    • Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands
    • doi:10.1016/j.bpj.2011.11.4018
    • Robert P, Aleksic M, Dushek O, Cerundolo V, Bongrand P, van der Merwe P. Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands. Biophys J (2012) 102(2):248-57. doi:10.1016/j.bpj.2011.11.4018.
    • (2012) Biophys J , vol.102 , Issue.2 , pp. 248-257
    • Robert, P.1    Aleksic, M.2    Dushek, O.3    Cerundolo, V.4    Bongrand, P.5    van der Merwe, P.6
  • 54
    • 0033826815 scopus 로고    scopus 로고
    • A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions
    • doi:10.1016/S1074-5521(00)00019-3
    • Cochran JR, Stern LJ. A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions. Chem Biol (2000) 7(9):683-96. doi:10.1016/S1074-5521(00)00019-3.
    • (2000) Chem Biol , vol.7 , Issue.9 , pp. 683-696
    • Cochran, J.R.1    Stern, L.J.2
  • 55
    • 84867423677 scopus 로고    scopus 로고
    • Non-catalytic tyrosine-phosphorylated receptors
    • doi:10.1111/imr.12008
    • Dushek O, Goyette J, Merwe PA. Non-catalytic tyrosine-phosphorylated receptors. Immunol Rev (2012) 250(1):258-76. doi:10.1111/imr.12008.
    • (2012) Immunol Rev , vol.250 , Issue.1 , pp. 258-276
    • Dushek, O.1    Goyette, J.2    Merwe, P.A.3
  • 56
    • 31144479383 scopus 로고    scopus 로고
    • CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement
    • Stone JD, Stern LJ. CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement. J Immunol (2006) 176(3):1498-505.
    • (2006) J Immunol , vol.176 , Issue.3 , pp. 1498-1505
    • Stone, J.D.1    Stern, L.J.2
  • 57
    • 84855492003 scopus 로고    scopus 로고
    • Timescales of the adaptive immune response
    • Molina-París C, Lythe G, editors. New York: Springer
    • Day M, Lythe G. Timescales of the adaptive immune response. In: Molina-París C, Lythe G, editors. Mathematical Models and Immune Cell Biology. New York: Springer (2011). p. 351-61.
    • (2011) Mathematical Models and Immune Cell Biology , pp. 351-361
    • Day, M.1    Lythe, G.2
  • 58
    • 33846224785 scopus 로고    scopus 로고
    • Full activation of the T cell receptor requires both clustering and conformational changes at CD3
    • doi:10.1016/j.immuni.2006.10.019
    • Minguet S, Swamy M, Alarcón B, Luescher IF, Schamel WW. Full activation of the T cell receptor requires both clustering and conformational changes at CD3. Immunity (2007) 26(1):43-54. doi:10.1016/j.immuni.2006.10.019.
    • (2007) Immunity , vol.26 , Issue.1 , pp. 43-54
    • Minguet, S.1    Swamy, M.2    Alarcón, B.3    Luescher, I.F.4    Schamel, W.W.5
  • 60
    • 84874040939 scopus 로고    scopus 로고
    • TCR nanoclusters as the framework for transmission of conformational changes and cooperativity
    • doi:10.3389/fimmu.2012.00115
    • Blanco R, Alarcón B. TCR nanoclusters as the framework for transmission of conformational changes and cooperativity. Front Immunol (2012) 3:115. doi:10.3389/fimmu.2012.00115.
    • (2012) Front Immunol , vol.3 , pp. 115
    • Blanco, R.1    Alarcón, B.2
  • 61
    • 34249694937 scopus 로고    scopus 로고
    • Dimerization of VEGF receptors and implications for signal transduction: a computational study
    • doi:10.1016/j.bpc.2007.03.010
    • Mac Gabhann F, Popel AS. Dimerization of VEGF receptors and implications for signal transduction: a computational study. Biophys Chem (2007) 128(2-3):125-39. doi:10.1016/j.bpc.2007.03.010.
    • (2007) Biophys Chem , vol.128 , Issue.2-3 , pp. 125-139
    • Mac Gabhann, F.1    Popel, A.S.2
  • 62
    • 0031927668 scopus 로고    scopus 로고
    • Formation of TCR dimers/trimers as a crucial step for T cell activation
    • doi:10.1002/(SICI)1521-4141(199808)28:08<2571::AID-IMMU2571>3.0.CO;2-T
    • Bachmann MF, Salzmann M, Oxenius A, Ohashi PS. Formation of TCR dimers/trimers as a crucial step for T cell activation. Eur J Immunol (1998) 28(8):2571-9. doi:10.1002/(SICI)1521-4141(199808)28:08<2571::AID-IMMU2571>3.0.CO;2-T.
    • (1998) Eur J Immunol , vol.28 , Issue.8 , pp. 2571-2579
    • Bachmann, M.F.1    Salzmann, M.2    Oxenius, A.3    Ohashi, P.S.4
  • 63
    • 0033485801 scopus 로고    scopus 로고
    • The role of T-cell receptor dimerization in T-cell activation
    • doi:10.1016/S0167-5699(99)01543-1
    • Bachmann MF, Ohashi PS. The role of T-cell receptor dimerization in T-cell activation. Immunol Today (1999) 20(12):568-76. doi:10.1016/S0167-5699(99)01543-1.
    • (1999) Immunol Today , vol.20 , Issue.12 , pp. 568-576
    • Bachmann, M.F.1    Ohashi, P.S.2
  • 64
    • 0033737310 scopus 로고    scopus 로고
    • A mathematical analysis of tcr serial triggering and down-regulation
    • doi:10.1002/1521-4141(200011)30:11<3219::AID-IMMU3219>3.0.CO;2-7
    • Sousa J, Carneiro J. A mathematical analysis of tcr serial triggering and down-regulation. Eur J Immunol (2000) 30:3219-27. doi:10.1002/1521-4141(200011)30:11<3219::AID-IMMU3219>3.0.CO;2-7.
    • (2000) Eur J Immunol , vol.30 , pp. 3219-3227
    • Sousa, J.1    Carneiro, J.2
  • 65
    • 33746114879 scopus 로고    scopus 로고
    • The kinetic-segregation model: TCR triggering and beyond
    • doi:10.1038/ni1369
    • Davis SJ, van der Merwe PA. The kinetic-segregation model: TCR triggering and beyond. Nat Immunol (2006) 7(8):803-9. doi:10.1038/ni1369.
    • (2006) Nat Immunol , vol.7 , Issue.8 , pp. 803-809
    • Davis, S.J.1    van der Merwe, P.A.2
  • 66
    • 84876009760 scopus 로고    scopus 로고
    • Systems model of T cell receptor proximal signaling reveals emergent ultra- sensitivity
    • doi:10.1371/journal.pcbi.1003004
    • Mukhopadhyay H, Cordoba S-P, Maini PK, van der Merwe PA, Dushek O. Systems model of T cell receptor proximal signaling reveals emergent ultra- sensitivity. PLoS Comput Biol (2013) 9(3):e1003004. doi:10.1371/journal.pcbi.1003004.
    • (2013) PLoS Comput Biol , vol.9 , Issue.3
    • Mukhopadhyay, H.1    Cordoba, S.-P.2    Maini, P.K.3    van der Merwe, P.A.4    Dushek, O.5
  • 67
    • 0028178784 scopus 로고
    • T cell receptor antagonist peptides induce positive selection
    • doi:10.1016/0092-8674(94)90169-4
    • Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell (1994) 76(1):17-27. doi:10.1016/0092-8674(94)90169-4.
    • (1994) Cell , vol.76 , Issue.1 , pp. 17-27
    • Hogquist, K.A.1    Jameson, S.C.2    Heath, W.R.3    Howard, J.L.4    Bevan, M.J.5    Carbone, F.R.6
  • 68
    • 34247203561 scopus 로고    scopus 로고
    • Recombinant murine gammaherpesvirus 68 (MHV-68) as challenge virus to test efficacy of vaccination against chronic virus infections in the mouse model
    • doi:10.1016/j.vaccine.2007.02.054
    • El-Gogo S, Staib C, Meyr M, Erfle V, Sutter G, Adler H. Recombinant murine gammaherpesvirus 68 (MHV-68) as challenge virus to test efficacy of vaccination against chronic virus infections in the mouse model. Vaccine (2007) 25(20):3934-45. doi:10.1016/j.vaccine.2007.02.054.
    • (2007) Vaccine , vol.25 , Issue.20 , pp. 3934-3945
    • El-Gogo, S.1    Staib, C.2    Meyr, M.3    Erfle, V.4    Sutter, G.5    Adler, H.6


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