Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

PLoS Computational Biology

Volumn 9, Issue 3, 2013, Pages

  Mukhopadhyay, Himadri ^a   Cordoba, Shaun Paul ^a   Maini, Philip K ^b   van der Merwe, P Anton ^a   Dushek, Omer ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIGENS; CELL MEMBRANES; CELL SIGNALING; CHEMICAL ACTIVATION; ENZYMES; T-CELLS;

CELL-BE; CELL/B.E; CELLULAR ACTIVATION; IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS; PHOSPHORYLATED RECEPTORS; SIGNALING CASCADES; SYSTEM MODELS; T CELLS RECEPTORS; T-CELL ANTIGEN RECEPTORS; ULTRASENSITIVITY;

PHOSPHORYLATION;

CHIMERIC ANTIGEN RECEPTOR; LYMPHOCYTE RECEPTOR; PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ZETA CHAIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; IMMUNORECEPTOR TYROSINE BASED ACTIVATION MOTIF; PROCESS MODEL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

EID: 84876009760     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003004     Document Type: Article

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