Acetogenin and prenylated flavonoids from helminthostachys zeylanica with inhibitory activity on superoxide generation and elastase release by neutrophils

Planta Medica

Volumn 76, Issue 5, 2010, Pages 447-453

  Huang, Yuan Chao ^a   Hwang, Tsong Long ^b   Yang, Yu Liang ^c   Wu, Shih Hsiung ^c   Hsu, Mei Hua ^a   Wang, Jih Pyang ^d   Chen, Sheng Chih ^a   Huang, Li Jiau ^a   Liaw, Chih Chuang ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Acetogenin; Elastase release; Helminthostachys zeylanica; Ophioglossaceae; Prenylated flavonoids; Superoxide generation

Indexed keywords

2 (3,4 DIHYDROXYPHENYL) 6 [(2,2 DIMETHYL 6 METHYLENECYCLOHEXYL)METHYL] 5,7 DIHYDROXYCHROMAN 4 ONE; 2 [3,4 DIHYDROXY 2 [(2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)METHYL]PHENYL] 3,5,7 TRIHYDROXY 4H CHROMEN 4 ONE; 4''A,5'',6'',7'',8'',8''A HEXAHYDRO 5,3',4' TRIHYDROXY 5'',5'',8''A HEXAHYDRO 5,3',4' TRIHYDROXY 5'',5'',8''A TRIMETHYL 4H CHROMENO[2'',3'':7,8]FLAVONE; 4''A,5'',6'',7'',8'',8''A HEXAHYDRO 5,3',4' TRIHYDROXY 5'',5'',8''A TRIMETHYL 4H CHROMENO[2'',3'',7,6]FLAVONE; 6 HYDROXY 8 PENTADECYLOXOCANE 2,7 DIONE; ACETOGENIN; CYTOCHALASIN B; ELASTASE; FLAVONOID; FORMYLMETHIONYLLEUCYLPHENYLALANINE; HELMINTHOSTACHYS ZEYLANICA EXTRACT; PLANT EXTRACT; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HL 60; CELL STRAIN U937; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; ENZYME RELEASE; FRACTIONATION; HELMINTHOSTACHYS ZEYLANICA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; LEUKEMIA CELL LINE; MEDICINAL PLANT; NEUTROPHIL; PRENYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; RHIZOME; SPECTROSCOPY;

ACETOGENINS; ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; FERNS; FLAVONOIDS; HUMANS; NEUTROPHILS; PANCREATIC ELASTASE; PLANT EXTRACTS; PRENYLATION; RHIZOME; SUPEROXIDES; YOUNG ADULT;

HELMINTHOSTACHYS ZEYLANICA; OPHIOGLOSSACEAE;

EID: 77950237784     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1186221     Document Type: Article

References (20)

1. Chiu N Y., Chang K H. The illustrated medicinal plants of Taiwan, Vol. 3. Taipei SMC Publishing, Inc. 1992 18
2. Suja S R., Latha P G., Pushpangadan P, Rajasekharan S. Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats. J Ethnopharmacol 2004 92 61-66
3. Chen C C., Huang Y L., Yeh P Y., Ou J C. Cyclized geranyl stilbenes from the rhizomes of Helminthostachys zeylanica. Planta Med 2003 69 964-967
4. Murakami T, Hagiwara M, Tanaka K, Chen C M. Chemical investigation of the contents of Helminthostachys zeylanica. I. Chem Pharm Bull 1973 21 1849-1851
5. Murakami T, Hagiwara M, Tanaka K, Chen C M. Chemical investigation of the contents of Helminthostachys zeylanica. II. Chem Pharm Bull 1973 21 1851-1852
6. Huang Y L., Yeh P Y., Shen C C., Chen C C. Antioxidant flavonoids from the rhizomes of Helminthostachys zeylanica. Phytochemistry 2003 64 1277-1283
7. Su B N., Park E J., Mbwambo Z H., Santarsiero B D., Mesecar A D., Fong H H. S., Pezzuto J M., Kinghorn A D. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient mosher ester procedure carried out in NMR tubes. J Nat Prod 2002 65 1278-1282
8. Liaw C C., Chang F R., Chen S L., Wu C C., Lee K H., Wu Y C. Novel cytotoxic monotetrahydrofuranic annonaceous acetogenins from Annona montana. Bioorg Med Chem 2005 13 4767-4776
9. Hwang T L., Li G L., Lan Y H., Chia Y C., Hsieh P W., Wu Y H., Wu Y C. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radic Biol Med 2009 46 520-528
10. Shen Y C., Chen S Y., Kuo Y H., Hwang T L., Chiang M Y., Khalil A T. Chemical transformation and biological activities of Ambrein, a major product of Ambergris from Physeter macrocephalus. J Nat Prod 2007 70 147-153
11. Makishima M, Kanatani Y, Yamamoto-Yamaguchi Y, Honma Y. Enhancement of activity of 1alpha, 25-dihydroxyvitamin D3 for growth inhibition and differentiation induction of human myelomonocytic leukemia cells by tretinoin tocoferil, an alpha-tocopherol ester of all-trans retinoic acid. Blood 1996 87 3384-3394
12. Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K, Watanabe M. Novel cell proliferation and cytotoxicity assays using a tetrazolium salt that produces a soluble formazan dye. In Vitro Toxicol 1995 8 187-190
13. Huang K F., Yen Y F. Constituents of Erythrina cariegata. J Chin Pharm 1995 47 493-500
14. Pradhan B P., Chakraborty G C., Subba A. Triterpenoid lactone from Leucas aspera. Phytochemistry 1990 29 1693-1695
15. Sasaki S. Handbook of proton-NMR spectra and data, 1st edition. New York Academic Press 1985 190
16. Sasaki S. Handbook of proton-NMR spectra and data, 1st edition. New York Academic Press 1985 289
17. Encarnación D R., Nogueiras C L., Salinas V H. A., Anthoni U, Nielsen P H., Christophersen C. Isolation of eriodictyol identical with Huazhongilexone from Solanum hindsianum. Acta Chem Scand 1999 53 375-377
18. Seo E K., Silva G L., Chai H B., Chagwedera T E., Farnsworth N R., Cordell G A., Pezzuto J M., Kinghorn A D. Cytotoxic prenylated flavanones from Monotes engleri. Phytochemistry 1997 45 509-515
19. phox and mediates respiratory burst activity in human neutrophils. J Immunol 2003 170 5302-5308
20. Sadhu C, Dick K, Tino W T., Staunton D E. Selective role of PI3K delta in neutrophil inflammatory responses. Biochem Biophys Res Commun 2003 308 764-769