HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylation

Neuropsychopharmacology

Volumn 39, Issue 6, 2014, Pages 1469-1478

  Montalvo Ortiz, Janitza L ^a   Keegan, Jack ^a   Gallardo, Christopher ^a   Gerst, Nicolas ^b   Tetsuka, Kazuhiro ^b   Tucker, Chris ^b   Matsumoto, Mitsuyuki ^b   Fang, Deyu ^a   Csernansky, John G ^a   Dong, Hongxin ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b ASTELLAS PHARMA GLOBAL DEVELOPMENT   (United States)

Author keywords

aging; entinostat (MS 275); epigenetics; haloperidol; mice; valproic acid (VPA)

Indexed keywords

ENTINOSTAT; HALOPERIDOL; HISTONE; HISTONE DEACETYLASE INHIBITOR; VALPROIC ACID; BENZAMIDE DERIVATIVE; DOPAMINE RECEPTOR BLOCKING AGENT; PYRIDINE DERIVATIVE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DEMENTIA; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; ENZYME INHIBITION; EPIGENETICS; HISTONE ACETYLATION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; ONCOGENE C FOS; PREFRONTAL CORTEX; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ACETYLATION; ANIMAL; BLOOD; C57BL MOUSE; CONDITIONING; DRUG EFFECTS; METABOLISM; ONCOGENE; PHYSIOLOGY;

ACETYLATION; AGING; ANIMALS; AVOIDANCE LEARNING; BENZAMIDES; CONDITIONING (PSYCHOLOGY); DOPAMINE ANTAGONISTS; GENES, FOS; HALOPERIDOL; HISTONE DEACETYLASE INHIBITORS; HISTONES; MALE; MICE; MICE, INBRED C57BL; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PYRIDINES; VALPROIC ACID;

EID: 84900807578     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.346     Document Type: Article

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