Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex

Neuropsychopharmacology

Volumn 27, Issue 2, 2002, Pages 152-162

  Kontkanen, Outi ^a   Lakso, Merja ^a   Wong, Garry ^a   Castrén, Eero ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Clozapine, Haloperidol; In situ hybridization; Schizophrenia; Transcription factors

Indexed keywords

BRAIN PROTEIN; CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CINGULATE GYRUS; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; MALE; MULTIGENE FAMILY; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PUTAMEN; RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; DNA-BINDING PROTEINS; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION; GYRUS CINGULI; HALOPERIDOL; MALE; NEURONS; PREFRONTAL CORTEX; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, WISTAR; RNA, MESSENGER; SCHIZOPHRENIA; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0036294383     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(02)00289-0     Document Type: Article

References (37)

1. Region-specific induction of deltaFosB by repeated administration of typical versus atypical antipsychotic drugs
2. Tissue concentrations of clozapine and its metabolites in the rat
3. Long-term expression of the 35,000 mol. wt fos-related antigen in rat brain after kainic acid treatment
4. Linear pharmacokinetics of haloperidol in the rat
5. Differences between antipsychotic drugs in persistence of brain levels and behavioral effects
6. The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: Cellular localization and pharmacological characterization
7. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum
8. The use of c-fos as a metabolic marker in neuronal pathway tracing
9. D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons
10. Supersensitivity psychosis in schizophrenic patients after sudden clozapine withdrawal
11. Effects of typical and atypical neuroleptics on Fos protein expression in the rat forebrain
12. Neuroleptic withdrawal in schizophrenic patients. A review of the literature
13. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
14. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments
15. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine
16. Mechanisms of action of atypical antipsychotic drugs: A critical analysis
17. Differential expression of immediate early genes in the superior cervical ganglion after nicotine treatment
18. Relapse following clozapine withdrawal: Effect of neuroleptic drugs and cyproheptadine
19. Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics
20. Induction of c-fos mRNA in rat medial prefrontal cortex by antipsychotic drugs: Role of dopamine D2 and D3 receptors
21. Induction of c-fos mRNA expression in rat striatum by neuroleptic drugs
22. Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun
23. Chronic DeltaFosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy
24. DeltaFosB: A molecular mediator of long-term neural and behavioral plasticity
25. Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine
26. Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens
27. Distribution of Fos- and Jun-related proteins and activator protein-1 composite factors in mouse brain induced by neuroleptics
28. The comparative effects of haloperidol, (-)-sulpiride, and SCH23390 on c-fos and c-jun mRNA expressions, and AP-1 DNA binding activity
29. Neuroleptics increase c-fos expression in the forebrain: Contrasting effects of haloperidol and clozapine
30. Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity
31. Enhancement of Laminar FosB Expression in Frontal Cortex of Rats Receiving Long Chronic Clozapine Administration
32. Expression of c-fos protein in brain: Metabolic mapping at the cellular level
33. Differential Fos-protein induction in rat forebrain regions after acute and long-term haloperidol and clozapine treatment
34. Limited participation of 5-HT(1A) and 5-HT(2A/2C) receptors in the clozapine-induced Fos-protein expression in rat forebrain regions
35. Cholinergic rebound and rapid onset psychosis following abrupt clozapine withdrawal
36. Expression of Fos protein in the limbic regions of the rat following haloperidol decanoate