The muscarinic acetylcholine receptor agonist BuTAC mediates antipsychotic-like effects via the M4 subtype

Neuropsychopharmacology

Volumn 38, Issue 13, 2013, Pages 2717-2726

  Watt, Marla L ^a   Rorick Kehn, Linda ^a   Shaw, David B ^a   Knitowski, Karen M ^a   Quets, Anne T ^a   Chesterfield, Amy K ^a   McKinzie, David L ^a   Felder, Christian C ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

acetylcholine; BuTAC; clozapine; conditioned avoidance response paradigm; haloperidol; muscarinic receptors

Indexed keywords

6 [4 BUTYLTHIO 1,2,5 THIADIAZOL 3 YL] 1 AZABICYCLO [3.2.1] OCTANE; CLOZAPINE; GUANINE NUCLEOTIDE BINDING PROTEIN; HALOPERIDOL; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG TARGETING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; AVOIDANCE LEARNING; CHO CELLS; CONDITIONING, OPERANT; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HALOPERIDOL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN BINDING; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M4; TROPANES;

EID: 84887991590     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.186     Document Type: Article

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