Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells

International Journal of Biochemistry and Cell Biology

Volumn 53, Issue , 2014, Pages 9-14

  Duluc, Lucie ^a,b   Jacques, Caroline ^a,b   Soleti, Raffaella ^a,b   Andriantsitohaina, Ramaroson ^a,b   Simard, Gilles ^a,b,c  

^a UNIVERSITÉ D'ANGERS   (France)

^b UNIVERSITÉ D'ANGERS   (France)

^c ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

Angiogenesis; Delphinidin; Mitochondria; Polyphenols; Vascular endothelial growth factor

Indexed keywords

CYTOCHROME C OXIDASE; DELPHINIDIN; DNA; MESSENGER RNA; MITOCHONDRIAL DNA; PROTEIN KINASE B; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; ANTHOCYANIN; VASCULOTROPIN A;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DNA CONTENT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; META ANALYSIS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NEOVASCULARIZATION (PATHOLOGY); ANIMAL; APOPTOSIS; BIOSYNTHESIS; CELL RESPIRATION; DRUG EFFECTS; GENETICS; MITOCHONDRIAL DYNAMICS; NEOPLASM; PATHOLOGY; RAT; SIGNAL TRANSDUCTION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTHOCYANINS; APOPTOSIS; CELL RESPIRATION; ENDOTHELIAL CELLS; HUMANS; MITOCHONDRIAL TURNOVER; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84900805614     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.03.030     Document Type: Article

References (26)

1. F. Afaq, N. Zaman, N. Khan, D.N. Syed, S. Sarfaraz, and M.A. Zaid et al. Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables Int J Cancer 123 2008 1508 1515
2. E. Andriambeloson, C. Magnier, G. Haan-Archipoff, A. Lobstein, R. Anton, and A. Beretz et al. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta J Nutr 128 1998 2324 2333
3. C. Baron-Menguy, A. Bocquet, A.L. Guihot, D. Chappard, M.J. Amiot, and R. Andriantsitohaina et al. Effects of red wine polyphenols on postischemic neovascularization model in rats: low doses are proangiogenic, high doses anti-angiogenic FASEB J 21 2007 3511 3521
4. M. Chalopin, A. Tesse, M.C. Martínez, D. Rognan, J.F. Arnal, and R. Andriantsitohaina Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium PLoS One 5 2010 e8554
5. J.Q. Chen, P.R. Cammarata, C.P. Baines, and J.D. Yager Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications Biochim Biophys Acta 1793 2009 1540 1570
6. A. Csiszar, N. Labinskyy, J.T. Pinto, P. Ballabh, H. Zhang, and G. Losonczy et al. Resveratrol induces mitochondrial biogenesis in endothelial cells Am J Physiol Heart Circ Physiol 297 2009 H13 H20
7. L. Duluc, C. Jacques, R. Soleti, F. Iacobazzi, G. Simard, and R. Andriantsitohaina Modulation of mitochondrial capacity and angiogenesis by red wine polyphenols via estrogen receptor, NADPH oxidase and nitric oxide synthase pathways Int J Biochem Cell Biol 45 2013 783 791
8. L. Favot, S. Martin, T. Keravis, R. Andriantsitohaina, and C. Lugnier Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis Cardiovasc Res 59 2003 479 487
9. C. Jacques, A. Chevrollier, D. Loiseau, L. Lagoutte, F. Savagner, and Y. Malthièry et al. mtDNA controls expression of the death associated protein 3 Exp Cell Res 312 2006 737 745
10. H.R. Hagland, L.I. Nilsson, L. Burri, J. Nikolaisen, R.K. Berge, and K.J. Tronstad Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA) Biochem Biophys Res Commun 430 2013 573 578
11. N. Hay Interplay between FOXO, TOR, and Akt Biochim Biophys Acta 1813 2011 1965 1970
12. S. Lagarrigue, E. Blanchet, J.S. Annicotte, and L. Fajas Emerging key role of cell cycle regulators in cell metabolism Med Sci 27 2011 508 513
13. S. Lamy, M. Blanchette, J. Michaud-Levesque, R. Lafleur, Y. Durocher, and A. Moghrabi et al. Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation Carcinogenesis 27 2006 989 996
14. S. Lamy, R. Lafleur, V. Bédard, A. Moghrabi, S. Barrette, and D. Gingras et al. Anthocyanidins inhibit migration of glioblastoma cells: structure-activity relationship and involvement of the plasminolytic system J Cell Biochem 100 2007 100 111
15. J. Lu, D.M. Wu, Y.L. Zheng, B. Hu, W. Cheng, and Z.F. Zhang Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice Free Radic Biol Med 52 2012 646 659
16. S. Martin, E. Andriambeloson, K. Takeda, and R. Andriantsitohaina Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production Br J Pharmacol 135 2002 1579 1587
17. S. Martin, L. Favot, R. Matz, C. Lugnier, and R. Andriantsitohaina Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2 Biochem Pharmacol 65 2003 669 675
18. S. Martin, G. Giannone, R. Andriantsitohaina, and M.C. Martinez Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis Br J Pharmacol 139 2003 1095 1102
19. E. Nisoli, E. Clementi, C. Paolucci, V. Cozzi, C. Tonello, and C. Sciorati et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide Science 299 2003 896 899
20. S. Renaud, and M. de Lorgeril Wine, alcohol, platelets, and the French paradox for coronary heart disease Lancet 339 1992 1523 1526
21. P. Rustin, J. Lebidois, D. Chretien, T. Bourgeron, J.F. Piechaud, and A. Rötig et al. Endomyocardial biopsies for early detection of mitochondrial disorders in hypertrophic cardiomyopathies J Pediatr 124 1994 224 228
22. R.C. Scarpulla Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator Ann N Y Acad Sci 1147 2008 321 334
23. K. Skemiene, G. Rakauskaite, S. Trumbeckaite, J. Liobikas, G.C. Brown, and V. Borutaite Anthocyanins block ischemia-induced apoptosis in the perfused heart and support mitochondrial respiration potentially by reducing cytosolic cytochrome c Int J Biochem Cell Biol 45 1 2013 23 29
24. D.N. Syed, F. Afaq, S. Sarfaraz, N. Khan, R. Kedlaya, and V. Setaluri et al. Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation Toxicol Appl Pharmacol 231 2008 52 60
25. J. Tanaka, S. Nakamura, K. Tsuruma, M. Shimazawa, H. Shimoda, and H. Hara Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis Phytother Res 26 2012 214 222
26. G.L. Wright, I.G. Maroulakou, J. Eldridge, T.L. Liby, V. Sridharan, and P.N. Tsichlis et al. VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase FASEB J 22 2008 3264 3275