Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle

Journal of Molecular Medicine

Volumn 90, Issue 10, 2012, Pages 1145-1160

  Franko, A ^a,e   Von Kleist Retzow, J C ^a   Bose M ^a   Sanchez Lasheras, C ^a   Brodesser, S ^a   Krut, O ^a   Kunz, W S ^b   Wiedermann, D ^c   Hoehn, M ^c   Stohr O ^a   Moll, L ^a   Freude, S ^a   Krone, W ^a,d   Schubert, M ^a,d   Wiesner, R J ^a,d  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Ceramides; High resolution polarography; In vivo NMR spectroscopy; Insulin receptor; Lipid metabolism; Mitochondrial biogenesis; Mitochondrial gene expression; Muscle metabolism; Type 2 diabetes mellitus

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; INSULIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; STREPTOZOCIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CHRONIC DISEASE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPOINSULINEMIA; IMMOBILIZATION; INSULIN METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIPID DIET; MALE; MITOCHONDRION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATION; PROTEIN EXPRESSION; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ANIMALS; AUTOPHAGY; BLOOD GLUCOSE; CARNITINE O-PALMITOYLTRANSFERASE; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; ELECTRON TRANSPORT; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; GENE EXPRESSION; GLUCOSYLCERAMIDES; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OBESITY; OXIDATIVE STRESS; OXYGEN CONSUMPTION; SIGNAL TRANSDUCTION; STREPTOZOCIN; TRANS-ACTIVATORS;

EID: 84867334803     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0887-y     Document Type: Article

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