Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB 1 receptors

British Journal of Pharmacology

Volumn 171, Issue 11, 2014, Pages 2767-2777

  Grassin Delyle, S ^a,e   Naline, E ^a,b   Buenestado, A ^a   Faisy, C ^a,c,d   Alvarez, J C ^b,e   Salvator, H ^a   Abrial, C ^a   Advenier, C ^a   Zemoura, L ^a   Devillier, P ^a,b  

^a FOCH HOSPITAL   (France)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d Therapeutic Implications Laboratoire d'Excellence GR Ex   (France)

^e RAYMOND POINCARÉ HOSPITAL   (France)

Author keywords

bronchi; cannabinoid; cholinergic fibres; humans; muscle contraction; receptors

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR AGONIST; DRONABINOL; O 1602; RIMONABANT; UNCLASSIFIED DRUG; CANNABINOID; CANNABINOID 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GPR55 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BRONCHODILATATION; CANNABIS SMOKING; CHOLINERGIC SYSTEM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; ELECTROSTIMULATION; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; AGONISTS; ANTAGONISTS AND INHIBITORS; BRONCHUS; DRUG EFFECTS; GENE EXPRESSION; GENETICS; IN VITRO STUDY; MIDDLE AGED; MUSCLE CONTRACTION; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRONCHI; CANNABINOIDS; ELECTRIC STIMULATION; FEMALE; GENE EXPRESSION; HUMANS; IN VITRO TECHNIQUES; MALE; MIDDLE AGED; MUSCLE CONTRACTION; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84900529807     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12597     Document Type: Article

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