Postmortem redistribution of THC in the pig

International Journal of Legal Medicine

Volumn 124, Issue 6, 2010, Pages 543-549

  Brunet, Bertrand ^a   Hauet, Thierry ^a   Hébrard, William ^b   Papet, Yves ^a   Mauco, Gérard ^a   Mura, Patrick ^a  

^a UNIVERSITÉ DE POITIERS   (France)

^b CEMAGREF   (France)

Author keywords

Animal model; Cannabinoids; Large White pig; Postmortem redistribution; THC

Indexed keywords

TETRAHYDROCANNABINOL;

ADIPOSE TISSUE; ANIMAL; ANIMAL MODEL; ARTICLE; AUTOPSY; BILE; BLOOD; BRAIN; CADAVER; HEART MUSCLE; INTRAVENOUS DRUG ADMINISTRATION; LIVER; LUNG; MALE; METABOLISM; SKELETAL MUSCLE; SPLEEN; SUBSTANCE ABUSE; SWINE; TISSUE DISTRIBUTION; VITREOUS BODY;

ADIPOSE TISSUE; ANIMALS; AUTOPSY; BILE; BRAIN; INJECTIONS, INTRAVENOUS; LIVER; LUNG; MALE; MODELS, ANIMAL; MUSCLE, SKELETAL; MYOCARDIUM; POSTMORTEM CHANGES; SPLEEN; SUBSTANCE ABUSE DETECTION; SWINE; TETRAHYDROCANNABINOL; TISSUE DISTRIBUTION; VITREOUS BODY;

EID: 78651225297     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-009-0403-2     Document Type: Article

References (33)

1. Pounder DJ, Jones GR (1990) Post-mortem drug redistribution-a toxicological nightmare. Forensic Sci Int 45:253-263
2. Hearn WL, Keran EE, Wei HA, Hime G (1991) Site-dependent postmortem changes in blood cocaine concentrations. J Forensic Sci 36:673-684
3. De Letter EA, Belpaire FM, Clauwaert KM, Lambert WE, Van Bocxlaer JF, Piette MH (2002) Post-mortem redistribution of 3,4- methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit. Part I: experimental approach after in vivo intravenous infusion. Int J Legal Med 116:216-224
4. Gerostamoulos J, Drummer OH (2000) Postmortem redistribution of morphine and its metabolites. J Forensic Sci 45:843-845
5. Bachs L, Morland H (2001) Acute cardiovascular fatalities following cannabis use. Forensic Sci Int 124:200-203
6. Huestis MA (2002) Cannabis-effects on human behavior and performance. Forensic Sci Rev 14:15-59
7. Kelly E, Darke S, Ross J (2004) A review of drug use and driving: epidemiology, impairment, risk factors and risk perceptions. Drug Alcohol Rev 23:319-344 (Pubitemid 39305501)
8. Mura P, Kintz P, Ludes B et al (2003) Comparison of the prevalence of alcohol, cannabis and other drugs between 900 injured drivers and 900 control subjects: results of a French collaborative study. Forensic Sci Int 133:79-85
9. Kudo K, Nagata T, Kimura K, Imamura T, Jitsufuchi N (1995) Sensitive determination of δ9-tetrahydrocannabinol in human tissues by GC-MS. J Anal Toxicol 19:87-90
10. Hilberg T, Ripel A, Slordal L, Bjorneboe A, Morland J (1999) The extent of postmortem drug redistribution in a rat model. J Forensic Sci 44:956-962
11. Leighty EG (1973) Metabolism and distribution of cannabinoids in rats after different methods of administration. Biochem Pharmacol 22:1613-1621
12. Harvey DJ (1988) In vivo metabolism of (+)-trans-delta-9- tetrahydrocannabinol in the mouse. Biomed Environ Mass Spectrom 15:117-122
13. Leuschner JT, Harvey DJ, Bullingham RE, Paton WD (1986) Pharmacokinetics of delta-9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses. Drug Metab Dispos 14:230-238
14. Brunet B, Doucet C, Venisse N, Hauet T, Hébrard W, Papet Y, Mauco G, Mura P (2006) Validation of Large White pig as an animal model for the study of cannabinoids metabolism: application to the study of THC distribution in tissues. Forensic Sci Int 161:169-174
15. Tumbleson ME (1986) Swine in biomedical research. In: Tumbleson ME (ed) Swine in biomedical research. Plenum Press, New York, p 5
16. Hilberg T, Ripel A, Smith AJ, Slordal L, Morland J, Bjorneboe A (1998) Postmortem amitriptyline pharmacokinetics in pigs after oral and intravenous routes of administration. J Forensic Sci 43:380-387
17. Flanagan RJ, Amin A, Seinen W (2003) Effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozapine concentrations in the domestic pig (Sus scrofa). Forensic Sci Int 132:9-17
18. Crandall CS, Kerrigan S, Aguero RL, Lavalley J, McKinney PE (2006) The influence of collection site and methods on postmortem morphine concentrations in a porcine model. J Anal Toxicol 30:651-658 (Pubitemid 44913016)
19. Moriya F, Hashimoto Y (1999) Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages postmortem. J Forensic Sci 44:10-16
20. Hilberg T, Rogde S, Morland J (1999) Postmortem drug redistribution-human cases related to results in experimental animals. J Forensic Sci 44:3-9
21. Pélissier-Alicot AL, Gaulier JM, Dupuis C, Feuerstein M, Leonetti G, Lachatre G, Marquet P (2006) Post-mortem redistribution of three beta-blockers in the rabbit. Int J Legal Med 120:226-232
22. Moffat AC, Osselton MD, Widdop B (2004) Clarke's analysis of drugs and poisons, 3rd edn. Pharmaceutical Press, London
23. Ohlsson A, Lindgren JE, Wahlen A, Agurell S, Hollister LE, Gillespie HK (1980) Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking. Clin Pharmacol Ther 28:409-416
24. Hilberg T, Morland J, Bjorneboe A (1994) Postmortem release of amitriptyline from the lungs; a mechanism of postmortem drug redistribution. Forensic Sci Int 64:47-55
25. Hilberg T, Bugge A, Beylich KM, Ingum J, Bjørneboe A, Mørland J (1993) An animal model of postmortem amitriptyline redistribution. J Forensic Sci 38:81-90
26. Pélissier-Alicot AL, Gaulier JM, Champsaur P, Marquet P (2003) Mechanisms underlying postmortem redistribution of drugs: a review. J Anal Toxicol 27:533-544
27. Yoshida H, Okumura K, Kamiya A, Hori R (1989) Accumulation mechanism of basic drugs in the isolated perfused rat lung. Chem Pharm Bull 37:450-453 (Pubitemid 19082588)
28. Johansson E, Norén K, Sjövall J, Halldin MM (1989) Determination of delta 1-tetrahydrocannabinol in human fat biopsies from marihuana users by gas chromatography-mass spectrometry. Biomed Chromatogr 3:35-38
29. Johansson E, Agurell S, Hollister LE, Halldin MM (1988) Prolonged apparent half-life of delta 1-tetrahydrocannabinol in plasma of chronic marijuana users. J Pharm Pharmacol 40:374-375
30. Briglia EJ, Bidanset JH, Dal Cortivo LA (1992) The distribution of ethanol in post-mortem blood specimens. J Forensic Sci 37:991-998
31. Garrett ER, Hunt CA (1974) Physiochemical properties, solubility, and protein binding of delta-9-tetrahydrocannabinol. J Pharm Sci 63:1056-1064
32. Stimpfl T, Reichel S (2007) Distribution of drugs of abuse within specific regions of the human brain. Forensic Sci Int 170:179-182
33. Mura P, Kintz P, Dumestre V, Raul S, Hauet T (2005) THC can be detected in brain while absent in blood. J Anal Toxicol 29:842-843