Commentary: Functional neuronal CB2 cannabinoid receptors in the CNS

Current Neuropharmacology

Volumn 9, Issue 1, 2011, Pages 205-208

  Onaivi, E S ^a,b  

^a WILLIAM PATERSON UNIVERSITY   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Cannabinoid; Cannabis; CB1; CB2; CNS; Endocannabinoids; Immune system; Marijuana

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ANTIDEPRESSANT AGENT; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABIS; ENDOCANNABINOID; RIMONABANT;

ALZHEIMER DISEASE; ARTICLE; BRAIN; BRAIN NERVE CELL; BREAST MILK; CANNABIS SMOKING; CENTRAL NERVOUS SYSTEM; DEPRESSION; ENCEPHALITIS; GENE EXPRESSION; GENE STRUCTURE; GENETIC VARIABILITY; HUMAN; HUNTINGTON CHOREA; IMMUNOCOMPETENT CELL; INFLAMMATION; MULTIPLE SCLEROSIS; NONHUMAN; OBESITY; PARKINSON DISEASE; PERINATAL DEVELOPMENT; PROTEIN FUNCTION; TRAUMATIC BRAIN INJURY;

EID: 79953061968     PISSN: 1570159X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157015911795017416     Document Type: Article

References (47)

1. Onaivi, E.S., Sugiura T and Di Marzo V., Eds. Endocannabinoids: The brain and body's marijuana and beyond. Boca Raton: CRC Taylor and Francis 2006.
2. Munro, S., Thomas, K.L., Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature, 1993, 365, 61-65.
3. Galiegue, S., Mary, S., Marchand, J., Dussossoy D., Carrière, D, Carayon, P, Bouaboula M., Shire, D., Le Fur, G., Casellas, P. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem., 1995, 232, 54-61.
4. Griffin, G., Wray, E.J, Tao, Q., McAllister, S.D., Rorrer, W.K., Aung, M.M., Martin, B.R., Abood, M.E. Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for CB2 receptor absence in the rat central nervous system. Eur. J. Pharmacol., 1999, 377, 117-125.
5. Benito, C., Núñez, E., Tolón, R.M., Carrier, E.J., Rábano, A., Hillard, C.J., Romero, J. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaqueassociated glia in Alzheimer's disease brains. J. Neurosci., 2003, 23, 11136-11141.
6. Ibrahim, M.M., Deng, H., Zvonok, A., Cockayne, D.A., Kwan, J., Mata, H.P., Vanderah, T.W., Lai, J., Porreca, F., Makriyannis, A., Malan, T.P. Jr. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the brain. Proc. Natl. Acad. Sci. USA, 2003, 100, 10529-10533.
7. Golech, S.A., McCarron, R.M., Chen, Y., Bembry, J., Lenz, F., Mechoulam, R., Shohami, E., Spatz, M. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. Mol. Brain Res., 2004, 132, 87-92.
8. Núñez, E., Benito, C., Pazos, M.R., Barbachano, A., Fajardo, O., González, S., Tolón, R.M., Romero, J. Cannabinoid CB2 receptors are expressed by perivascular microglia cells in the human brain: An immunohistochemical study. Synapse, 2004, 53, 208-213.
9. Benito, C., Kim, W.K., Chavarría, I., Hillard, C.J., Mackie, K., Tolón, R. M., Williams, K., Romero, J. A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. J. Neurosci., 2005, 25, 2530-2536.
10. Sheng, W.S., Hu, S., Min, X., Cabral, G.A., Lokensgard, J.R., Peterson, P.K. Synthetic cannabinoid WIN55212-2 inhibits generation of inflammatory mediators by IL-IB-stimulated human astrocytes. Glia, 2005, 49, 211-219.
11. Palazuelos, J., Aguado, T., Egia, A., Mechoulam, R., Guzmán, M., Galve-Roperh, I. Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation. FASEB J., 2006, 20, 2405-2407.
12. Brusco A, Tagliaferro P, Saez T, Onaivi E.S. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse, 2008, 62, 944-949.
13. Chin, C.L., Tovcimak, A.E., Hradil, V.P., Seifert, T.R., Hollingsworth, P.R., Chandran, P., Zhu, C.Z., Gauvin, D., Pai, M., Wetter, J., Hsieh, G.C., Honore, P., Frost, J.M., Dart, M.J., Meyer, M.D., Yao, B.B., Cox, B.F., Fox G.B. Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI. Br. J. Pharmacol., 2008, 153, 367-379.
14. Viscomi, M.T., Oddi, S., Latini, L., Pasquariello, N., Florenzano, F., Bernardi, G., Molinari, M., Maccarrone, M. Selective CB2 receptor agonism protects central neurons from remote axotomyinduced apoptosis through the P13K/Akt pathway. J. Neurosci., 2009, 29, 4564-4570.
15. Onaivi, E.S. Neuropsychopharmacological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology, 2006, 54, 231-246.
16. Ishiguro, H., Iwasaki, S., Teasenfitz, L., Higuchi, S., Horiuchi, Y., Saito, T., Arinami, T., Onaivi, E.S. Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans. Pharmacogenomics. J., 2007, 7, 380-385.
17. Onaivi, E.S., Ishiguro, H., Gong, J.P., Patel, S., Meozzi, P.A., Myers, L, Perchuk A, Mora Z, Tagliaferro P.A, Gardner E, Brusco A, Akinshola B.E, Liu Q.R, Chirwa S.S, Hope B, Lujilde, J., Inada, T., Iwasaki, S., Macharia, D., Teasenfitz, L., Arinami, T., Uhl, G.R. Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. Ann. N.Y. Acad. Sci., 2008, 1130, 434-449.
18. Pazos, M.R., Núñez, E., Benito, C., Tolón, R.M., Romero, J. Role of the endocannabinoid system in Alzheimer's disease: New perspectives. Life Sci., 2004, 75, 1907-1915.
19. Benito, C., Tolón, R.M., Pazos, M.R., Núñez, E., Castillo, A.I., Romero, J. Cannabinoid CB2 receptors in human brain inflammation. Br. J. Pharmacol., 2008, 153, 277-285.
20. Páldyová E, Bereczki E, Sántha M, Wenger T, Borsodi A, Benyhe S. Noladin ether, a putative endocannabinoid, inhibits mu-opoid receptor activation via CB2 cannabinoid receptors. Neurochem Int., 2008, 52, 321-328.
21. Páldy E, Bereczki E, Sántha M, Wenger T, Borsodi A, Zimmer A, Benyhe S. CB(2) cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB2 receptor in pain. Neurochem. Int., 2008, 53, 309-316.
22. Onaivi, E.S., Ishiguro, H., Gong, J-P., Patel, S., Perchuk, A., Meozzi, P.A., Myers, L., Mora, Z., Tagliaferro, P., Gardner, E., Brusco, A., Akinshola, B.E., Liu, Q-R., Hope, B., Iwasaki, S., Arinami, T., Teasenfitz, L., Uhl, G.R. Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann. N.Y. Acad. Sci., 2006, 1074, 514-536.
23. Fernández-Ruiz, J., Romero, J., Velasco, G., Tolón, R.M., Ramos, J.A., Guzmán, M. Cannabinoid CB2 receptor: a new target for controlling neural cell survival. Trends Pharmacol. Sci., 2006, 28, 39-45.
24. Van, S.M.D, Duncan, M., Kingsley, P.J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J.S., Marnett, L.J., Di Marzo, V., Pittman, Q.J., Patel, K.D., Sharkey, K.A. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science, 2005, 310, 329-332.
25. Gong, J-P., Onaivi, E.S., Ishiguro, H., Liu, Q-R., Tagliaferro, P.A., Brusco, A., Uhl, G.R. Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain. Brain Res., 2006, 1071, 10-23.
26. Suárez, J., Bermúdez-Silva, F.J., Mackie, K., Ledent, C., Zimmer, A., Cravatt, B.F., de Fonseca, F.R. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. J. Comp. Neurol., 2008, 509, 400-421.
27. Suárez, J., Llorente, R., Romero-Zerbo, S.Y., Mateos, B., Bermúdez-Silva, F.J., de Fonseca, F.R., Viveros, M.P. Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB1 and CB2 cannabinoid receptors of neonatal rats. Hippocampus, 2009, 19, 623-632.
28. Koch, M., Habazettl, I., Dehghani, F., Korf, H.W. The rat pineal gland comprises an endocannabinoid system. J. Pineal Res., 2008, 45, 351-360.
29. Brown, S.M., Wager-Miller, J., Mackie, K. Cloning and molecular characterization of rat CB2 cannabinoid receptor. Biochim. Biophys. Acta, 2002, 1576, 277-285.
30. Shire, D., Calandra, B., Rinaldi-Carmona, M., Oustric, D., Pessègue, B., Bonnin-Cabanne, O., Le Fur, G., Caput, D., Ferrara, P. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. Biochim. Biophys. Acta, 1996, 1307, 132-136.
31. Abood, M.E. Molecular biology of cannabinoid receptors. Handb Exp. Pharmacol., 2005, 168, 81-115.
32. Liu, Q-R., Pan, C.H., Hishimoto, A., Li, C.Y., Xi, Z.X., Llorente- Berzal, A., Viveros, M.P., Ishiguro, H., Arinami, T., Onaivi, E.S., Uhl, G.R. Species differences in cannabinoid receptor 2 (CNR2 gene): Identification of novel human and rodent CB2 isoforms, differential tissue expression, and regulation by cannabinoid receptor ligands. Gene Brain Behav., 2009, 8, 519-530.
33. Grimsey, N.L., Goodfellow, C.E., Scotter, E.L., Dowie, M.J., Glass, M., Graham, E.S. Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal. J. Neurosci. Meth., 2008, 171, 78-86.
34. Buckley, N.E., McCoy, K.L., Mezey, E., Bonner, T., Zimmer, A., Felder, C.C., Glass M., Zimmer, A. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor. Eur. J. Pharmacol., 2000, 396, 141-149.
35. Brusco, A., Taglaiferro, P.A., Saez, T., Onaivi, E.S. Ultrastructural localization of neuronal brain CB2 cannabinoid receptors. Ann. N.Y. Acad. Sci., 2008, 1139, 450-457.
36. Ong, W.Y., Mackie, K. A light and electron microscopic study of the CB1 cannabinoid receptor in primate spinal cord. J. Neurocytol., 1999, 28, 39-45.
37. Baek, J.H., Zheng, Y., Darlington, C.L., Smith, P.F. Cannabinoid CB2 receptor expression in the rat brainstem cochlear and vestibular nuclei. Acta Oto-Laryngol., 2008, 128, 961-967.
38. Ashton, J.C., Friberg D., Darlington, C.L., Smith, P.F. Expression of the cannabinoid CB2 receptor in the rat cerebellum: an immunohistochemical study. Neurosci. Lett., 2006, 396, 113-116.
39. Onaivi, E.S., Carpio, O., Ishiguro, H., Schanz, N., Uhl, G.R., Benno, R. Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption. Ann. N. Y. Acad. Sci., 2008, 1139, 426-433.
40. Vinod, K.Y., Hungund, B.L. Endocannabinoid lipids and mediated system: Implication for alcoholism and neuropsychiatric disorders. Life Sci., 2005, 77, 1569-1583.
41. Basavarajappa, B.S., Hungund, B.L. Role of the endocannabinoid system in the development of tolerance to alcohol. Alcohol Alcoholism, 2005, 40, 15-24.
42. Sipe, J.C., Arbour, N., Gerber, A., Beutler, E. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. J. Leukoc. Biol., 2005, 78, 231-238.
43. Karsak, M., Cohen-Solal, M., Freudenberg, J., Ostertag, A., Morieux, C., Kornak, U., Essig J, Erxlebe, E., Bab, I., Kubisch, C., de Vernejoul, M.C., Zimmer, A. The cannabinoid receptor type 2 (CNR2) gene is associated with human osteoporosis. Hum. Mol. Genet., 2005, 14, 3389-3396.
44. Cook, R.T. Alcohol abuse, alcoholism, and damage to the immune system -a review. Alcohol Clin. Exp. Res., 1998, 22, 1927-1942.
45. Onaivi, E.S., Ishiguro, H., Sejal, P., Meozzi, P.A., Myers, L., Tagliaferro, P., Hope, B., Leonard, C.M., Uhl, G.R., Brusco, A., Gardner, E. Methods to study the behavioral effects and expression of CB2 cannabinoid receptors and its gene transcripts in chronic mild stress model of depression. In Onaivi E.S., Ed.; Marijuana and cannabinoid research: Methods and Protocols. Totowa, Humana press Inc, 2006, pp 291-298.
46. Uhl, G.R, Ishiguro, H., Onaivi, E.S., Zhang, P.W., Akinshola, B.E., Lin, Z., Hope, B., Leonard, C.M., Liu, Q-R. Molecular neurobiological methods in marijuana-cannabinoid research: in Onaivi, E.S (ed): Marijuana and cannabinoid research: Methods and Protocols. Totowa, Humana press Inc, 2006, pp 1-17.
47. Lanciego JL, Barroso-Chinea P, Rico AJ, Conte-Perales L, Callén L, Roda E, Gómez-Bautista V, López IP, Lluis C, Labandeira-García JL, Franco R. J. Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis. J. Psychopharmacol., 2011, 25, 97-104.