CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 19, 2014, Pages

  Martínez Muñoz, Laura ^a   Barroso, Rubén ^a   Dyrhaug, Sunniva Y ^a   Navarro, Gemma ^b   Lucas, Pilar ^a   Soriano, Silvia F ^c,d   Vega, Beatriz ^a   Costas, Coloma ^a   Angeles Munoz Fernandez M ^c   Santiago, César ^a   Frade, José Miguel Rodríguez ^a   Franco, Rafael ^b   Mellado, Mario ^a  

^a CSIC   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^d CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

Chemokine receptors; FRET BRET; Oligomer formation

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 120 IIIB; HETERODIMER; HOMODIMER; LIM KINASE 1; OLIGOMER; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUSION; CELL MEMBRANE; CELL SURFACE; CELL SUSPENSION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; JURKAT CELL LINE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

CHEMOKINE RECEPTORS; FRET/BRET; OLIGOMER FORMATION;

ACTIN DEPOLYMERIZING FACTORS; ANTIGENS, CD4; CELL FUSION; DIMERIZATION; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELLS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; JURKAT CELLS; LIM KINASES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, CCR5; RECEPTORS, CXCR4; TH1 CELLS; TH2 CELLS;

EID: 84900514907     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322887111     Document Type: Article

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