ADSC therapy in neurodegenerative disorders

Cell Transplantation

Volumn 23, Issue 4-5, 2014, Pages 549-557

  Chan, Tzu Min ^a,b   Chen, Julia Yi Ru ^c   Ho, Li Ing ^d   Lin, Hui Ping ^e   Hsueh, Kuo Wei ^f   Liu, Demeral David ^a,g   Chen, Yi Hung ^f   Hsieh, An Cheng ^a   Tsai, Nu Man ^h,i   Hueng, Dueng Yuan ^j   Tsai, Sheng Tzeng ^k   Chou, Pei Wen ^b,c   Lin, Shinn Zong ^f,g   Harn, Horng Jyh ^a,f  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b Everfront Biotech Inc   (Taiwan)

^c Guang Li Biomedicine Inc   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

^g CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

^h CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

ⁱ CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^j TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^k TZU CHI UNIVERSITY   (Taiwan)

more..

Author keywords

Adipose tissue derived stem cells (ADSCs); Alzheimer's disease; Amyotrophic lateral sclerosis; Autoimmune encephalomyelitis; Friedreich's ataxia; Huntington's disease; Krabbe disease; Neurodegenerative disorders; Niemann Pick disease; Parkinson's disease

Indexed keywords

ADIPOSE DERIVED STEM CELL; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CELL HOMING; CELL LINEAGE; CHRONIC DISEASE; CLINICAL TRIAL (TOPIC); DEGENERATIVE DISEASE; EXTRACELLULAR MATRIX; HUMAN; HUNTINGTON CHOREA; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; STEM CELL TRANSPLANTATION; ADIPOSE TISSUE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; HUNTINGTON DISEASE; NEURODEGENERATIVE DISEASES; STEM CELL;

ADIPOSE TISSUE; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; HUMANS; HUNTINGTON DISEASE; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 84900461138     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368914X678445     Document Type: Review

References (88)

1. Aubeeluck, A.; Brewer, H. Huntington's disease. Part 2: Treatment and management issues in juvenile HD. Br. J. Nurse 17(4):260-263; 2008.
2. Bae, J. S.; Carter, J. E.; Jin, H. K. Adipose tissue-derived stem cells rescue Purkinje neurons and alleviate inflammatory responses in Niemann-Pick disease type C mice. Cell Tissue Res. 340(2):357-369; 2010.
3. Bae, K. S.; Park, J. B.; Kim, H. S.; Kim, D. S.; Park, D. J.; Kang, S. J. Neuron-like differentiation of bone marrow-derived mesenchymal stem cells. Yonsei Med. J. 52(3):401-412; 2011.
4. Bartzokis, G. Alzheimer's disease as homeostatic responses to age-related myelin breakdown. Neurobiol. Aging 32(8): 1341-1371; 2011.
5. Butler, D.; Nixon, R. A.; Bahr, B. A. Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases. Autophagy 2(3):234-237; 2006.
6. Caplan, A. I.; Dennis, J. E. Mesenchymal stem cells as trophic mediators. J. Cell. Biochem. 98(5):1076-1084; 2006.
7. Ching, J. K.; Elizabeth, S. V.; Ju, J. S.; Lusk, C.; Pittman, S. K.; Weihl, C. C. mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy. Hum. Mol. Genet. 22(6):1167-1179; 2013.
8. Chivet, M.; Javalet, C.; Hemming, F.; Pernet-Gallay, K.; Laulagnier, K.; Fraboulet, S.; Sadoul, R. Exosomes as a novel way of interneuronal communication. Biochem. Soc. Trans. 41(1):241-244; 2013.
9. Chong, Z. Z.; Shang, Y. C.; Wang, S.; Maiese, K. Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin. Prog. Neurobiol. 99(2):128-148; 2012.
10. Chun, W.; Johnson, G. V. The role of tau phosphorylation and cleavage in neuronal cell death. Front. Biosci. 12:733-756; 2007.
11. Dantuma, E.; Merchant, S.; Sugaya, K. Stem cells for the treatment of neurodegenerative diseases. Stem Cell Res. Ther. 1(5):37; 2010.
12. Diaz, D.; Recio, J. S.; Weruaga, E.; Alonso, J. R. Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells. Cell Transplant. 21(7):1595-1602; 2012.
13. Ebadi, M.; Brown-Borg, H.; Ren, J.; Sharma, S.; Shavali, S.; El ReFaey, H.; Carlson, E. C. Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases. Curr. Drug Targets 7(11):1513-1529; 2006.
14. Faust, K.; Gehrke, S.; Yang, Y.; Yang, L.; Beal, M. F.; Lu, B. Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. BMC Neurosci. 10:109; 2009.
15. Fedorova, N. V.; Iablonskaia, A.; Bel'gusheva, M. E. [Levodopa medications in the treatment of Parkinson's disease]. Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 111(5):30-36; 2011.
16. Fernandez-Checa, J. C.; Fernandez, A.; Morales, A.; Mari, M.; Garcia-Ruiz, C.; Colell, A. Oxidative stress and altered mitochondrial function in neurodegenerative diseases: Lessons from mouse models. CNS Neurol. Disord. Drug Targets 9(4):439-454; 2010.
17. Ferraiuolo, L.; Kirby, J.; Grierson, A. J.; Sendtner, M.; Shaw, P. J. Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat. Rev. Neurol. 7(11):616-630; 2011.
18. Ferri, C. P.; Prince, M.; Brayne, C.; Brodaty, H.; Fratiglioni, L.; Ganguli, M.; Hall, K.; Hasegawa, K.; Hendrie, H.; Huang, Y.; Jorm, A.; Mathers, C.; Menezes, P. R.; Rimmer, E.; Scazufca, M.; Alzheimer's Disease International. Global prevalence of dementia: A Delphi consensus study. Lancet 366(9503):2112-2117; 2005.
19. Francis, P. T.; Palmer, A. M.; Snape, M.; Wilcock, G. K. The cholinergic hypothesis of Alzheimer's disease: A review of progress. J. Neurol. Neurosurg. Psychiatry 66(2):137-147; 1999.
20. Gaiottino, J.; Norgren, N.; Dobson, R.; Topping, J.; Nissim, A.; Malaspina, A.; Bestwick, J. P.; Monsch, A. U.; Regeniter, A.; Lindberg, R. L.; Kappos, L.; Leppert, D.; Petzold, A.; Giovannoni, G.; Kuhle, J. Increased neurofilament light chain blood levels in neurodegenerative neurological diseases. PLoS One 8(9):e75091; 2013.
21. Ghani, M.; Sato, C.; Lee, J. H.; Reitz, C.; Moreno, D.; Mayeux, R.; St George-Hyslop, P.; Rogaeva, E. Evidence of recessive Alzheimer disease loci in a Caribbean Hispanic data set: Genome-wide survey of runs of homozygosity. JAMA Neurol. 70(10):1261-1267; 2013.
22. Gir, P.; Oni, G.; Brown, S. A.; Mojallal, A.; Rohrich, R. J. Human adipose stem cells: Current clinical applications. Plast. Reconstr. Surg. 129(6):1277-1290; 2012.
23. Gitlin, L. N.; Hauck, W. W.; Dennis, M. P.; Winter, L. Maintenance of effects of the home environmental skillbuilding program for family caregivers and individuals with Alzheimer's disease and related disorders. J. Gerontol. A Biol. Sci. Med. Sci. 60(3):368-374; 2005.
24. Glascock, J. J.; Osman, E. Y.; Coady, T. H.; Rose, F. F.; Shababi, M.; Lorson, C. L. Delivery of therapeutic agents through intracerebroventricular (ICV) and intravenous (IV) injection in mice. J. Vis. Exp. 56:2968; 2011.
25. Goldstein, D. S. Biomarkers, mechanisms, and potential prevention of catecholamine neuron loss in Parkinson disease. Adv. Pharmacol. 68:235-272; 2013.
26. Gombash, S. E.; Lipton, J. W.; Collier, T. J.; Madhavan, L.; Steece-Collier, K.; Cole-Strauss, A.; Terpstra, B. T.; Spieles-Engemann, A. L.; Daley, B. F.; Wohlgenant, S. L.; Thompson, V. B.; Manfredsson, F. P.; Mandel, R. J.; Sortwell, C. E. Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Mol. Ther. 20(3):544-554; 2012.
27. Gu, H.; Wang, J.; Du, N.; Tan, J.; Johnstone, B.; Du, Y. Adipose stromal cells-conditioned medium blocks 6-hydroxydopamine-induced neurotoxicity and reactive oxygen species. Neurosci. Lett. 544:15-19; 2013.
28. Halliday, M.; Mallucci, G. R. Targeting the unfolded protein response in neurodegeneration: A new approach to therapy. Neuropharmacology 76(Pt. A):169-174; 2014.
29. Hsu, Y. C.; Chen, S. L.; Wang, D. Y.; Chiu, I. M. Stem cellbased therapy in neural repair. Biomed. J. 36(3):98-105; 2013.
30. Im, W.; Ban, J.; Lim, J.; Lee, M.; Lee, S. T.; Chu, K.; Kim, M. Extracts of adipose derived stem cells slows progression in the R6/2 model of Huntington's disease. PLoS One 8(4):e59438; 2013.
31. Im, W.; Lee, S. T.; Park, J. E.; Oh, H. J.; Shim, J.; Lim, J.; Chu, K.; Kim, M. Transplantation of patient-derived adipose stem cells in YAC128 Huntington's disease transgenic mice. PLoS Curr. 2:RRN1183; 2010.
32. Iyer, S.; Alsayegh, K.; Abraham, S.; Rao, R. R. Stem cellbased models and therapies for neurodegenerative diseases. Crit. Rev. Biomed. Eng. 37(4-5):321-353; 2009.
33. Jones, J.; Estirado, A.; Redondo, C.; Bueno, C.; Martinez, S. Human adipose stem cell-conditioned medium increases survival of Friedreich's ataxia cells submitted to oxidative stress. Stem Cells Dev. 21(15):2817-2826; 2012.
34. Jucker, M.; Walker, L. C. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 501(7465):45-51; 2013.
35. Kalia, L. V.; Kalia, S. K.; McLean, P. J.; Lozano, A. M.; Lang, A. E. alpha-Synuclein oligomers and clinical implications for Parkinson disease. Ann. Neurol. 73(2):155-169; 2013.
36. Kato, A. C.; Vingerhoets, F. J.; Magistris, M. R.; Kuntzer, T.; Burkhard, P. R. [Pathogenic mechanisms of neurodegenerative diseases: Amyotrophic lateral sclerosis]. Rev. Med. Suisse 2(64):1152-1154, 1156-1157; 2006.
37. Kim, K. S.; Lee, H. J.; An, J.; Kim, Y. B.; Ra, J. C.; Lim, I.; Kim, S. U. Transplantation of human adipose tissue-derived stem cells delays clinical onset and prolongs life span in ALS mouse model. Cell Transplant; 2013.
38. Kim, S.; Chang, K. A.; Kim, J.; Park, H. G.; Ra, J. C.; Kim, H. S.; Suh, Y. H. The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice. PLoS One 7(9):e45757; 2012.
39. Lauren, J.; Gimbel, D. A.; Nygaard, H. B.; Gilbert, J. W.; Strittmatter, S. M. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457(7233):1128-1132; 2009.
40. Lee, I. S.; Jung, K.; Kim, M.; Park, K. I. Neural stem cells: Properties and therapeutic potentials for hypoxic-ischemic brain injury in newborn infants. Pediatr. Int. 52(6):855-865; 2010.
41. Lei, P.; Ayton, S.; Finkelstein, D. I.; Spoerri, L.; Ciccotosto, G. D.; Wright, D. K.; Wong, B. X.; Adlard, P. A.; Cherny, R. A.; Lam, L. Q.; Roberts, B. R.; Volitakis, I.; Egan, G. F.; McLean, C. A.; Cappai, R.; Duce, J. A.; Bush, A. I. Tau deficiency induces Parkinsonism with dementia by impairing APP-mediated iron export. Nat. Med. 18(2):291-295; 2012.
42. Li, X.; Li, H.; Li, X. J. Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases. Brain Res. Rev. 59(1):245-252; 2008.
43. Lindvall, O.; Kokaia, Z.; Martinez-Serrano, A. Stem cell therapy for human neurodegenerative disorders-How to make it work. Nat. Med. 10(Suppl):S42-S50; 2004.
44. Liu, S. P.; Fu, R. H.; Huang, S. J.; Huang, Y. C.; Chen, S. Y.; Chang, C. H.; Liu, C. H.; Tsai, C. H.; Shyu, W. C.; Lin, S. Z. Stem cell applications in regenerative medicine for neurological disorders. Cell Transplant. 22(4):631-637; 2013.
45. Lu, D. Y.; Chen, J. H.; Tan, T. W.; Huang, C. Y.; Yeh, W. L.; Hsu, H. C. Resistin protects against 6-hydroxydopamineinduced cell death in dopaminergic-like MES23.5 cells. J. Cell. Physiol. 228(3):563-571; 2013.
46. Ma, T.; Gong, K.; Ao, Q.; Yan, Y.; Song, B.; Huang, H.; Zhang, X.; Gong, Y. Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice. Cell Transplant. 22(S1):113-126; 2013.
47. Mandel, S. A.; Youdim, M. B. In the rush for green gold: Can green tea delay age-progressive brain neurodegeneration? Recent Pat. CNS Drug Discov. 7(3):205-217; 2012.
48. Marconi, S.; Bonaconsa, M.; Scambi, I.; Squintani, G. M.; Rui, W.; Turano, E.; Ungaro, D.; D'Agostino, S.; Barbieri, F.; Angiari, S.; Farinazzo, A.; Constantin, G.; Del Carro, U.; Bonetti, B.; Mariotti, R. Systemic treatment with adiposederived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model. Neuroscience 248C:333-343; 2013.
49. Maucksch, C.; Vazey, E. M.; Gordon, R. J.; Connor, B. Stem cell-based therapy for Huntington's disease. J. Cell. Biochem. 114(4):754-763; 2013.
50. Mejia-Toiber, J.; Castillo, C. G.; Giordano, M. Strategies for the development of cell lines for ex vivo gene therapy in the central nervous system. Cell Transplant. 20(7):983-1001; 2011.
51. Mitrecic, D.; Nicaise, C.; Gajovic, S.; Pochet, R. Distribution, differentiation, and survival of intravenously administered neural stem cells in a rat model of amyotrophic lateral sclerosis. Cell Transplant. 19(5):537-548; 2010.
52. Morita, E.; Watanabe, Y.; Ishimoto, M.; Nakano, T.; Kitayama, M.; Yasui, K.; Fukada, Y.; Doi, K.; Karunaratne, A.; Murrell, W. G.; Sutharsan, R.; Mackay-Sim, A.; Hata, Y.; Nakashima, K. A novel cell transplantation protocol and its application to an ALS mouse model. Exp. Neurol. 213(2):431-438; 2008.
53. Moriyama, M.; Moriyama, H.; Ueda, A.; Nishibata, Y.; Okura, H.; Ichinose, A.; Matsuyama, A.; Hayakawa, T. Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling. BMC Cell Biol. 13:21; 2012.
54. Nucifora, Jr., F. C.; Sasaki, M.; Peters, M. F.; Huang, H.; Cooper, J. K.; Yamada, M.; Takahashi, H.; Tsuji, S.; Troncoso, J.; Dawson, V. L.; Dawson, T. M.; Ross, C. A. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 291(5512):2423-2428; 2001.
55. Papadeas, S. T.; Maragakis, N. J. Advances in stem cell research for amyotrophic lateral sclerosis. Curr. Opin. Biotechnol. 20(5):545-551; 2009.
56. Pérez-González, R.; Antequera, D.; Vargas, T.; Spuch, C.; Bolos, M.; Carro, E. Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimer's disease. J. Alzheimers Dis. 24(Suppl 2):17-25; 2011.
57. Pohanka, M. Cholinesterases, a target of pharmacology and toxicology. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 155(3):219-229; 2011.
58. Ra, J. C.; Kang, S. K.; Shin, I. S.; Park, H. G.; Joo, S. A.; Kim, J. G.; Kang, B. C.; Lee, Y. S.; Nakama, K.; Piao, M.; Sohl, B.; Kurtz, A. Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells. J. Transl. Med. 9:181; 2011.
59. Ra, J. C.; Shin, I. S.; Kim, S. H.; Kang, S. K.; Kang, B. C.; Lee, H. Y.; Kim, Y. J.; Jo, J. Y.; Yoon, E. J.; Choi, H. J.; Kwon, E. Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans. Stem Cells Dev. 20(8):1297-1308; 2011.
60. Radtke, C.; Wewetzer, K.; Reimers, K.; Vogt, P. M. Transplantation of olfactory ensheathing cells as adjunct cell therapy for peripheral nerve injury. Cell Transplant. 20(2):145-152; 2011.
61. Ragonese, P.; Cellura, E.; Aridon, P.; D'Amelio, M.; Spataro, R.; Taiello, A. C.; Maimone, D.; La Bella, V.; Savettieri, G. Incidence of amyotrophic lateral sclerosis in Sicily: A population based study. Amyotroph Lateral. Scler. 13(3):284-287; 2012.
62. Rasmussen, M. A.; Hall, V. J.; Carter, T. F.; Hyttel, P. Directed differentiation of porcine epiblast-derived neural progenitor cells into neurons and glia. Stem Cell Res. 7(2):124-136; 2011.
63. Rhinn, H.; Fujita, R.; Qiang, L.; Cheng, R.; Lee, J. H.; Abeliovich, A. Integrative genomics identifies APOE epsilon4 effectors in Alzheimer's disease. Nature 500(7460): 45-50; 2013.
64. Riley, B. E.; Orr, H. T. Polyglutamine neurodegenerative diseases and regulation of transcription: Assembling the puzzle. Genes Dev. 20(16):2183-2192; 2006.
65. Riordan, N. H.; Ichim, T. E.; Min, W. P.; Wang, H.; Solano, F.; Lara, F.; Alfaro, M.; Rodriguez, J. P.; Harman, R. J.; Patel, A. N.; Murphy, M. P.; Lee, R. R.; Minev, B. Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis. J. Transl. Med. 7:29; 2009.
66. Ripoll, C. B.; Flaat, M.; Klopf-Eiermann, J.; Fisher-Perkins, J. M.; Trygg, C. B.; Scruggs, B. A.; McCants, M. L.; Leonard, H. P.; Lin, A. F.; Zhang, S.; Eagle, M. E.; Alvarez, X.; Li, Y. T.; Li, S. C.; Gimble, J. M.; Bunnell, B. A. Mesenchymal lineage stem cells have pronounced anti-inflammatory effects in the twitcher mouse model of Krabbe's disease. Stem Cells 29(1):67-77; 2011.
67. Rivas-Arancibia, S.; Willing, A. E.; Zigova, T.; Rodriguez, A. I.; Cahill, D. W.; Sanberg, P. R. The effects of taurine on hNT neurons transplanted in adult rat striatum. Cell Transplant. 9(6):751-758; 2000.
68. Roos, R. A. Huntington's disease: A clinical review. Orphanet J. Rare Dis. 5(1):40; 2010.
69. Samii, A.; Nutt, J. G.; Ransom, B. R. Parkinson's disease. Lancet 363(9423):1783-1793; 2004.
70. Sato, Y.; Oohira, A. Chondroitin sulfate, a major niche substance of neural stem cells, and cell transplantation therapy of neurodegeneration combined with niche modification. Curr. Stem Cell Res. Ther. 4(3):200-209; 2009.
71. Scruggs, B. A.; Semon, J. A.; Zhang, X.; Zhang, S.; Bowles, A. C.; Pandey, A. C.; Imhof, K. M.; Kalueff, A. V.; Gimble, J. M.; Bunnell, B. A. Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model. Stem Cells Transl. Med. 2(10):797-807; 2013.
72. Song, S.; Zhang, H.; Cuevas, J.; Sanchez-Ramos, J. Comparison of neuron-like cells derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem Cells Dev. 16(5):747-756; 2007.
73. Su, B.; Wang, X.; Nunomura, A.; Moreira, P. I.; Lee, H. G.; Perry, G.; Smith, M. A.; Zhu, X. Oxidative stress signaling in Alzheimer's disease. Curr. Alzheimer Res. 5(6):525-532; 2008.
74. Subramaniam, S.; Sixt, K. M.; Barrow, R.; Snyder, S. H. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science 324(5932):1327-1330; 2009.
75. Tanaka, Y.; Yoshikura, N.; Harada, N.; Yamada, M.; Koumura, A.; Sakurai, T.; Hayashi, Y.; Kimura, A.; Hozumi, I.; Inuzuka, T. Late-onset patients with sporadic amyotrophic lateral sclerosis in Japan have a higher progression rate of ALSFRS-R at the time of diagnosis. Intern. Med. 51(6):579-584; 2012.
76. Tanzi, R. E. A brief history of Alzheimer's disease gene discovery. J. Alzheimers Dis. 33(Suppl 1):S5-S13; 2013.
77. Tomita, K.; Madura, T.; Sakai, Y.; Yano, K.; Terenghi, G.; Hosokawa, K. Glial differentiation of human adipose-derived stem cells: Implications for cell-based transplantation therapy. Neuroscience 236:55-65; 2013.
78. Torrente, Y.; Polli, E. Mesenchymal stem cell transplantation for neurodegenerative diseases. Cell Transplant. 17(10-11): 1103-1113; 2008.
79. Uccelli, A.; Milanese, M.; Principato, M. C.; Morando, S.; Bonifacino, T.; Vergani, L.; Giunti, D.; Voci, A.; Carminati, E.; Giribaldi, F.; Caponnetto, C.; Bonanno, G. Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis. Mol. Med. 18:794-804; 2012.
80. van der Marck, M. A.; Kalf, J. G.; Sturkenboom, I. H.; Nijkrake, M. J.; Munneke, M.; Bloem, B. R. Multidisciplinary care for patients with Parkinson's disease. Parkinsonism Relat. Disord. 15(Suppl 3):S219-S223; 2009.
81. Vercelli, A.; Mereuta, O. M.; Garbossa, D.; Muraca, G.; Mareschi, K.; Rustichelli, D.; Ferrero, I.; Mazzini, L.; Madon, E.; Fagioli, F. Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis. 31(3):395-405; 2008.
82. Vila, M.; Przedborski, S. Targeting programmed cell death in neurodegenerative diseases. Nat. Rev. Neurosci. 4(5):365-375; 2003.
83. Walker, L. C.; Diamond, M. I.; Duff, K. E.; Hyman, B. T. Mechanisms of protein seeding in neurodegenerative diseases. JAMA Neurol. 70(3):304-310; 2013.
84. Ying, Z.; Wang, H.; Wang, G. The ubiquitin proteasome system as a potential target for the treatment of neurodegenerative diseases. Curr. Pharm. Des. 19(18):3305-3314; 2013.
85. Zerovnik, E. Protein conformational pathology in Alzheimer's and other neurodegenerative diseases; new targets for therapy. Curr. Alzheimer Res. 7(1):74-83; 2010.
86. Zhou, L.; Miranda-Saksena, M.; Saksena, N. K. Viruses and neurodegeneration. Virol. J. 10:172; 2013.
87. Zhou, Y.; Sun, M.; Li, H.; Yan, M.; He, Z.; Wang, W.; Lu, S. Recovery of behavioral symptoms in hemi-parkinsonian rhesus monkeys through combined gene and stem cell therapy. Cytotherapy 15(4):467-480; 2013.
88. Zuk, P. A.; Zhu, M.; Mizuno, H.; Huang, J.; Futrell, J. W.; Katz, A. J.; Benhaim, P.; Lorenz, H. P.; Hedrick, M. H. Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng. 7(2):211-228; 2001.