Neural stem cells: Properties and therapeutic potentials for hypoxic-ischemic brain injury in newborn infants

Pediatrics International

Volumn 52, Issue 6, 2010, Pages 855-865

  Lee, Il Shin ^a   Jung, Kwangsoo ^a   Kim, Miri ^a   Park, Kook In ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

cell replacement; gene therapy; hypoxic ischemic brain injury; neural stem cells

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; SCAFFOLD PROTEIN; STROMAL CELL DERIVED FACTOR 1ALPHA;

ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CADAVER; CAROTID ARTERY LIGATION; CELL MIGRATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; GENE DELIVERY SYSTEM; GENE THERAPY; GESTATIONAL AGE; GLIA CELL; HEMATOPOIESIS; HUMAN; IMMUNOCYTOCHEMISTRY; INFANT; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NERVE FIBER; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NEWBORN; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STABLE EXPRESSION; SYNAPSE;

ANIMALS; BRAIN; CELL DIFFERENTIATION; CELL MOVEMENT; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; GENE THERAPY; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; NEURAL STEM CELLS; NEUROGENESIS; TISSUE ENGINEERING;

EID: 78650483449     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2010.03266.x     Document Type: Article

References (73)

1. Gage FH, Ray J, Fisher LJ,. Isolation, characterization and use of stem cells from the CNS. Annu. Rev. Neurosci. 1995; 18: 159-62.
2. McKay R,. Stem cells in the central nervous system. Science 1997; 276: 66-71.
3. Gage FH,. Mammalian neural stem cells. Science 2000; 287: 1433-8.
4. Snyder EY, Sidman RL, Goodell MA, Daley GQ,. Taking stock and planning for the next decade: Realistic prospects for stem cell therapies for the nervous system. J. Neurosci. Res. 2004; 76: 157-68.
5. Imitola J, Park KI, Teng YD, et al. Stem cells: Cross-talk and developmental programs. Philos. Trans. R. Soc. Lond., B. 2004; 359: 823-37.
6. Park KI, Hack MA, Ourednik J, et al. Acute injury directs the migration, proliferation, & differentiation of solid organ stem cells: Evidence from the effect of hypoxia-ischemia in the CNS on clonal "reporter" neural stem cells. Exp. Neurol. 2006; 199: 156-78.
7. Ryder EF, Snyder EY, Cepko CL,. Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer. J. Neurobiol. 1990; 21: 356-75.
8. Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartweig EA, Cepko CL,. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 1992; 68: 33-51.
9. Snyder EY, Yoon CH, Flax JD, Macklis JD,. Multipotent neural progenitors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex. Proc. Natl Acad. Sci. USA 1997; 94: 11663-8.
10. Magavi SS, Leavitt BR, Macklis JB,. Induction of neurogenesis in the neocortex of adult mice. Nature 2001; 405: 951-5.
11. Weissman IL, Anderson DJ, Gage F,. Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 2001; 17: 387-403.
12. Anderson DJ, Gage FH, Weissman IL,. Can stem cells cross lineage boundaries? Nat. Med. 2001; 7: 935-9.
13. Navarro-Galve B, Martinez-Serrano A,. "Is there any need to argue. " about the nature and genetic signature of in vitro neural stem cells? Exp. Neurol. 2006; 199: 20-5.
14. Yandava BD, Billinghurst L, Snyder EY,. "Global" cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain. Proc. Natl Acad. Sci. U.S.A. 1999; 96: 7029-34.
15. Park KI, Teng YD, Snyder EY,. The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat. Biotechnol. 2002; 20: 1111-17.
16. Rosario CM, Yandava BD, Kosaras B, Zurakowski D, Sidman RL, Snyder EY,. Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action. Development 1997; 124: 4213-24.
17. Imitola J, Raddassi K, Park KI, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc. Natl Acad. Sci. USA 2004; 101: 18117-22.
18. Snyder EY, Taylor RM, Wolfe JH,. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature 1995; 374: 367-70.
19. Hodges H, Sinden J, Meldrum B, Gray J,. Cerebral transplantation in animal models of ischemia. In:, Dunnett SB, Bjorklund A, (eds). Functional Neural Transplantation. Raven Press, New York, 1994; 347-86.
20. Park KI, Jensen FE, Stieg PE, Snyder EY,. Hypoxic-ischemic (HI) injury may direct the proliferation, migation, and differentiation of endogenous neural progenitors. Soc. Neurosci. Abstr. 1998; 24: 1310.
21. Snyder EY, Park KI,. Limitations in brain repair. Nat. Med. 2002; 8: 928-30.
22. Park KI, Ourednik J, Ourednik V, et al. Global gene and cell replacement strategies via stem cells. Gene Ther. 2002; 9: 613-24.
23. Ghosh A, Greenberg ME,. Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. Neuron 1995; 15: 89-103.
24. Vicario-Abejon C, Johe KK, Hazel TG, Collazo D, McKay RDG,. Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons. Neuron 1995; 15: 105-14.
25. Park KI, Himes BT, Stieg PE, Tessler A, Fischer I, Snyder EY,. Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3 (NT-3)-expressing stem cells in hypoxic-ischemic brain injury. Exp. Neurol. 2006; 199: 179-90.
26. Martinez-Serrano A, Lundberg C, Horellou P, et al. CNSderived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: Complete rescue of axotomized cholinergic neurons after transplantation into septum. J. Neurosci. 1995; 15: 5668-80.
27. Martinez-Serrano A, Fischer W, Bjorklund A,. Reversal of age dependent cognitive impairments and cholinergic neuron atrophy by NGFsecreting neural progenitors grafted to the basal forebrain. Neuron 1995; 15: 473-84.
28. Martinez-Serrano A, Bjorklund A,. Protection of the neostriatum against excitotoxic damage by neurotrophin-producing genetically modified neural stem cells. J. Neurosci. 1996; 16: 4604-16.
29. Behrstock S, Ebert A, McHugh J, et al. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther. 2006; 13: 379-88.
30. Rubio FJ, Kokai Z, del Arco A, et al. BDNF gene transfer to the mammalian brain using CNS-derived neural precursors. Gene Ther. 1999; 6: 1851-66.
31. Park KI, Liu S, Flax JD, Nissim S, Stieg PE, Snyder EY,. Transplantation of neural progenitor and stem-like cells: Developmental insights may suggest new therapies for spinal cord and other CNS dysfunction. J. Neurotrauma 1999; 16: 675-87.
32. Kim BS, Mooney DJ,. Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol. 1998; 16: 224-30.
33. Nerem RM, Sambanis A,. Tissue engineering: From biology to biological substitutes. Tissue Eng. 1995; 1: 3-13.
34. Langer R, Vacanti JP,. Tissue engineering. Science 1993; 260: 920-6.
35. Rakic P, Caviness VS Jr,. Cortical development: View from neurological mutants two decades later. Neuron 1995; 14: 1101-4.
36. Deuel TF,. Growth factors. In:, Lanza RP, Langer R, Chick WL, (eds). Principles of Tissue Engineering. Academic Press, San Diego, CA, 1997; 133-50.
37. Shea LD, Smiley E, Bonadio J, Mooney DJ,. DNA delivery from polymer matrices for tissue engineering. Nat. Biotechnol. 1999; 17: 551-4.
38. Teng YD, Lavik EB, Qu X, et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc. Natl Acad. Sci. USA 2002; 99: 3024-9.
39. Schier AF,. Chemokine signaling: Rules of attraction. Curr. Biol. 2003; 13: R192-R194.
40. Zlotnik A, Yoshie O,. Chemokines: A new classification system and their role in immunity. Immunity 2000; 12: 121-7.
41. Horuk R,. Chemokine receptors. Cytokine Growth Factor Rev. 2001; 12: 313-35.
42. Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996; 382: 635-8.
43. Ma Q, Jones D, Springer TA,. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 1999; 10: 463-71.
44. Bagri A, Gurney T, He X, et al. The chemokine SDF-1 regulates migration of dentate granule cells. Development 2002; 129: 4249-60.
45. Zhou Y, Larsen PH, Hao C, Yong VW,. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J. Biol. Chem. 2002; 277: 49481-7.
46. Rubin JB, Kung AL, Klein RS, et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc. Natl Acad. Sci. USA 2003; 100: 13513-18.
47. Sun L, Lee J, Fine HA,. Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury. J. Clin. Invest. 2004; 113: 1364-74.
48. Martino G, Pluchino S,. The therapeutic potential of neural stem cells. Nat. Rev. Neurosci. 2006; 7: 395-406.
49. Pluchino S, Quattrini A, Brambilla E, et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 2003; 422: 688-94.
50. Pluchino S, Zanotti L, Rossi B, et al. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 2005; 436: 266-71.
51. Reynolds BA, Weiss S,. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992; 255: 1707-10.
52. Svendsen CN, Caldwell MA, Shen J, et al. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp. Neurol. 1997; 148: 135-46.
53. Flax JD, Aurora S, Yang C, Simonin C, Willis AM, Billinghurst LL,. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign proteins. Nat. Biotechnol. 1998; 16: 1033-9.
54. Carpenter MK, Cui X, Hu Z-Y, et al. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 1999; 158: 265-78.
55. Vescovi AL, Parati EA, Gritti A, et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp. Neurol. 1999; 156: 71-83.
56. Kim H-T, Kim I-S, Lee I-S, Lee J-P, Snyder EY, Park KI,. Human neurospheres derived from the fetal central nervous system are regionally and temporally specified but are not committed. Exp. Neurol. 2006; 199: 222-35.
57. Reynolds BA, Weiss S,. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev. Biol. 1996; 175: 1-13.
58. Svendsen CN, Caldwell MA,. Neural stem cells in the developing central nervous system: Implications for cell therapy through transplantation. Prog. Brain Res. 2000; 127: 13-34.
59. Suslov ON, Kukekov VG, Ignatova TN, Steindler DA,. Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres. Proc. Natl Acad. Sci. USA 2002; 99: 14506-11.
60. Vescovi AL, Snyder EY,. Establishment and properties of neural stem cell clones: Plasticity in vitro and in vivo. Brain Pathol. 1999; 9: 569-98.
61. Daley GQ, Goodell MA, Snyder EY,. Realistic prospects for stem cell therapeutics. Hematology (Am. Soc. Hematol. Educ. Program). 2003; 1: 398-418.
62. Ourednik V, Ourednik J, Flax JD, et al. Segregation of human neural stem cells in the developing primate forebrain. Science 2001; 293: 1820-4.
63. Fricker RA, Carpenter MK, Winkler C, Greco C, Gates MA, Bjorklund A,. Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J. Neurosci. 1999; 19: 5990-6005.
64. Rubio FJ, Bueno C, Villa A, Navarro B, Martinez-Serrano A,. Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain. Mol. Cell. Neurosci. 2000; 16: 1-13.
65. Uchida N, Buck DW, He D, et al. Direct isolation of human central nervous system stem cells. Proc. Natl Acad. Sci. USA 2000; 97: 14720-5.
66. Redmond DE, Bjugstad KB, Teng YD, et al. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proc. Natl Acad. Sci. USA 2007; 104: 12175-80.
67. Kelly S, Bliss TM, Shah AK, et al. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc. Natl Acad. Sci. USA 2004; 101: 11839-44.
68. Lee JP, Jeyakumar M, Gonzalez R, et al. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat. Med. 2007; 13: 439-47.
69. Cummings BJ, Uchida N, Tamaki SJ, et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cordinjured mice. Proc. Natl Acad. Sci. USA 2005; 102: 14069-74.
70. Park KI, Snyder EY,. Transplantation of human neural stem cells, propagated by either genetic or epigenetic means, into hypoxic-ischemic (HI) brain injury. Soc. Neurosci. Abstr. 1999; 25: 212.
71. Park KI, Lee KH, Lee BH, Teng YD, Snyder EY,. Transplanted human neural stem cells replace lost neural cells and promote neuronal reinnervation and functional recovery in injured rat spinal cord. Soc. Neurosci. Abstr. 2002; 825: 9.
72. Bjorklund A, Lindvall O,. Cell replacement therapies for central nervous system disorders. Nat. Neurosci. 2000; 3: 537-44.
73. Parsons XH, Teng YD, Snyder EY,. Important precautions when deriving patient-specific neural elements from pluripotent cells. Cytotherapy 2009; 11: 1-11.