Specificity of anti-Tau antibodies when analyzing mice models of Alzheimer's disease: Problems and solutions

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Petry, Franck R ^a,b   Pelletier, Jér̂ome ^a,b   Bretteville, Alexis ^a,b   Morin, Françoise ^b   Calon, Fréd́eric ^a,b   H́ebert, Sébastien S ^a,b   Whittington, Robert A ^c   Planel, Emmanuel ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c Centre de Recherche du CHU de Québec CHUL Axe Neurosciences ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY AT180; MONOCLONAL ANTIBODY AT270; MONOCLONAL ANTIBODY AT8; MONOCLONAL ANTIBODY CP13; MONOCLONAL ANTIBODY CP27; MONOCLONAL ANTIBODY DA9; MONOCLONAL ANTIBODY MC1; MONOCLONAL ANTIBODY MC6; MONOCLONAL ANTIBODY PHF 1; MONOCLONAL ANTIBODY TAU1; MONOCLONAL ANTIBODY TAU12; MONOCLONAL ANTIBODY TAU46; MONOCLONAL ANTIBODY TG 3; MONOCLONAL ANTIBODY TG5; POLYCLONAL ANTIBODY; POLYCLONAL ANTIBODY A0024; POLYCLONAL ANTIBODY PS199; POLYCLONAL ANTIBODY PS262; POLYCLONAL ANTIBODY PS396; POLYCLONAL ANTIBODY PS404; POLYCLONAL ANTIBODY PS409; POLYCLONAL ANTIBODY PS422; POLYCLONAL ANTIBODY PT205; TAU ANTIBODY; UNCLASSIFIED DRUG; TAU PROTEIN;

3XTG AD MOUSE; ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; ARTIFACT; CLEARANCE; CONTROLLED STUDY; EXPERIMENTAL MOUSE; HUMAN VERSUS ANIMAL COMPARISON; HYPOTHERMIC MOUSE; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE MODEL; NON TRANSGENIC MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DISEASE MODEL; GENE INACTIVATION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ARTIFACTS; DISEASE MODELS, ANIMAL; GENE KNOCKOUT TECHNIQUES; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; TAU PROTEINS;

EID: 84900429512     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094251     Document Type: Article

References (33)

1. Querfurth HW, LaFerla FM (2010) Alzheimer's disease. The New England journal of medicine 362: 329-344.
2. Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiological reviews 81: 741-766.
3. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, et al. (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proceedings of the National Academy of Sciences of the United States of America 83: 4913-4917.
4. Buée L, Bussière T, Buée-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain research Brain research reviews 33: 95-130.
5. Alonso AC, Zaidi T, Grundke-Iqbal I, Iqbal K (1994) Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America 91: 5562-5566. (Pubitemid 24174368)
6. Ballatore C, Lee VM-Y, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nature reviews Neuroscience 8: 663-672. (Pubitemid 47283144)
7. St-Amour I, Pare I, Alata W, Coulombe K, Ringuette-Goulet C, et al. (2013) Brain bioavailability of human intravenous immunoglobulin and its transport through the murine blood-brain barrier. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism.
8. Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI, et al. (2001) Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. Journal of cell science 114: 1179-1187. (Pubitemid 32288531)
9. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, et al. (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39: 409-421. (Pubitemid 36937044)
10. Planel E, Richter KEG, Nolan CE, Finley JE, Liu L, et al. (2007) Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. The Journal of neuroscience: the official journal of the Society for Neuroscience 27: 3090-3097.
11. Tucker KL, Meyer M, Barde YA (2001) Neurotrophins are required for nerve growth during development. Nature neuroscience 4: 29-37.
12. Planel E, Yasutake K, Fujita SC, Ishiguro K (2001) Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. The Journal of biological chemistry 276: 34298-34306.
13. d'Abramo C, Acker CM, Jimenez HT, Davies P (2013) Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity. PloS one 8: e62402.
14. Jicha GA, Lane E, Vincent I, Otvos L, Jr., Hoffmann R, et al. (1997) A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease. Journal of neurochemistry 69: 2087-2095. (Pubitemid 27452756)
15. Herskovits AZ, Davies P (2006) The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease. Neurobiology of disease 23: 398-408. (Pubitemid 44109668)
16. Duff K, Knight H, Refolo LM, Sanders S, Yu X, et al. (2000) Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiology of disease 7: 87-98. (Pubitemid 30241205)
17. Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, et al. (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293: 1487-1491. (Pubitemid 32801551)
18. Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, et al. (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314: 130-133. (Pubitemid 44547757)
19. Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, et al. (2008) Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of neuroscience: the official journal of the Society for Neuroscience 28: 12798-12807.
20. Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, et al. (2001) Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293: 711-714. (Pubitemid 32728676)
21. Zempel H, Thies E, Mandelkow E, Mandelkow EM (2010) Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. The Journal of neuroscience: the official journal of the Society for Neuroscience 30: 11938-11950.
22. Burnette WN (1981) ''Western blotting'': electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Analytical biochemistry 112: 195-203.
23. Renart J, Reiser J, Stark GR (1979) Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure. Proceedings of the National Academy of Sciences of the United States of America 76: 3116-3120. (Pubitemid 9233242)
24. Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences of the United States of America 76: 4350-4354. (Pubitemid 9256559)
25. Porter RR (1959) The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. The Biochemical journal 73: 119-126.
26. Janke C, Beck M, Stahl T, Holzer M, Brauer K, et al. (1999) Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders. Brain research Molecular brain research 68: 119-128. (Pubitemid 29244000)
27. Goedert M (1996) Tau protein and the neurofibrillary pathology of Alzheimer's disease. Annals of the New York Academy of Sciences 777: 121-131.
28. Yu Y, Run X, Liang Z, Li Y, Liu F, et al. (2009) Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases. Journal of neurochemistry 108: 1480-1494.
29. Jicha GA, Bowser R, Kazam IG, Davies P (1997) Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J Neurosci Res 48: 128-132. (Pubitemid 27181338)
30. Weaver CL, Espinoza M, Kress Y, Davies P (2000) Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiol Aging 21: 719-727.
31. Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, et al. (2005) Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes & development 19: 827-839.
32. Couchie D, Nunez J (1985) Immunological characterization of microtubule-associated proteins specific for the immature brain. FEBS letters 188: 331-335. (Pubitemid 16249754)
33. Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW (1975) A protein factor essential for microtubule assembly. Proceedings of the National Academy of Sciences of the United States of America 72: 1858-1862.