Assessment of myocardial infarction and postinfarction scar remodeling with an elastin-specific magnetic resonance agent

Circulation: Cardiovascular Imaging

Volumn 7, Issue 2, 2014, Pages 321-329

  Wildgruber, Moritz ^a,e   Bielicki, Isabella ^a   Aichler, Michaela ^b   Kosanke, Katja ^a   Feuchtinger, Annette ^b   Settles, Marcus ^a   Onthank, David C ^c   Cesati, Richard R ^c   Robinson, Simon P ^c   Huber, Armin M ^a   Rummeny, Ernst J ^a   Walch, Axel K ^b   Botnar, Reń M ^d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c Clinical Research   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Magnetic Resonance Imaging; Molecular Imaging; Myocardial Infarction; Ventricular Remodeling

Indexed keywords

ELASTIN SPECIFIC MAGNETIC RESONANCE CONTRAST AGENT; GADOLINIUM; GADOLINIUM PENTETATE MEGLUMINE; LANTHANUM; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY LIGATION; ARTICLE; CONTRAST TO NOISE RATIO; ELASTIC FIBER; FEMALE; HEART EJECTION FRACTION; HEART INFARCTION; HEART INFARCTION SIZE; HISTOLOGY; IMAGE ENHANCEMENT; IMAGING SYSTEM; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; WESTERN BLOTTING;

MAGNETIC RESONANCE IMAGING; MOLECULAR IMAGING; MYOCARDIAL INFARCTION; VENTRICULAR REMODELING;

ANIMALS; CICATRIX; CONTRAST MEDIA; CORONARY VESSELS; DISEASE MODELS, ANIMAL; ELASTIC TISSUE; ELASTIN; FEMALE; FOLLOW-UP STUDIES; GADOLINIUM DTPA; MAGNETIC RESONANCE IMAGING, CINE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIUM; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 84900418655     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.113.001270     Document Type: Article

References (33)

1. Konstam MA, Kramer DG, Patel AR, Maron MS, Udelson JE. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. JACC Cardiovasc Imaging. 2011;4:98-108.
2. Leuschner F, Nahrendorf M. Molecular imaging of coronary atherosclerosis and myocardial infarction: considerations for the bench and perspectives for the clinic. Circ Res. 2011;108:593-606.
3. Bassett EG, Wakefield JS. Elastic fibers in myocardial scars in rats: development teraction with other components. Connect Tissue Res. 2008;49:321-327.
4. Mizuno T, Mickle DA, Kiani CG, Li RK. Overexpression of elastin fragments in infarcted myocardium attenuates scar expansion and heart dysfunction. Am J Physiol Heart Circ Physiol. 2005;288:H2819-H2827.
5. Mizuno T, Yau TM, Weisel RD, Kiani CG, Li RK. Elastin stabilizes an infarct and preserves ventricular function. Circulation. 2005;112(9 suppl):I81-I88.
6. Makowski MR, Wiethoff AJ, Blume U, Cuello F, Warley A, Jansen CH, Nagel E, Razavi R, Onthank DC, Cesati RR, Marber MS, Schaeffter T, Smith A, Robinson SP, Botnar RM. Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent. Nat Med. 2011;17:383-388.
7. Kellman P, Arai AE, McVeigh ER, Aletras AH. Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement. Magn Reson Med. 2002;47:372-383.
8. Wildgruber M, Settles M, Kosanke K, Bielicki I, Ntziachristos V, Rummeny EJ, Botnar RM, Huber AM. Evaluation of phase-sensitive versus magnitude reconstructed inversion recovery imaging for the assessment of myocardial infarction in mice with a clinical magnetic resonance scanner. J Magn Reson Imaging. 2012;36:1372-1382.
9. Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation. 2000;101:2981-2988.
10. Chareonthaitawee P, Christian TF, Hirose K, Gibbons RJ, Rumberger JA. Relation of initial infarct size to extent of left ventricular remodeling in the year after acute myocardial infarction. J Am Coll Cardiol. 1995;25:567-573.
11. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation. 1990;81:1161-1172.
12. Solomon SD, Glynn RJ, Greaves S, Ajani U, Rouleau JL, Menapace F, Arnold JM, Hennekens C, Pfeffer MA. Recovery of ventricular function after myocardial infarction in the reperfusion era: the healing and early afterload reducing therapy study. Ann Intern Med. 2001;134:451-458.
13. Matsui Y, Morimoto J, Uede T. Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction. World J Biol Chem. 2010;1:69-80.
14. Lichtenauer M, Mildner M, Baumgartner A, Hasun M, Werba G, Beer L, Altmann P, Roth G, Gyongyosi M, Podesser BK, Ankersmit HJ. Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction. Basic Res Cardiol. 2011;106:645-655.
15. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204:3037-3047.
16. Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW II, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007;101:313-321.
17. Helm PA, Caravan P, French BA, Jacques V, Shen L, Xu Y, Beyers RJ, Roy RJ, Kramer CM, Epstein FH. Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent. Radiology. 2008;247:788-796.
18. Caravan P, Das B, Dumas S, Epstein FH, Helm PA, Jacques V, Koerner S, Kolodziej A, Shen L, Sun WC, Zhang Z. Collagen-targeted MRI contrast agent for molecular imaging of fibrosis. Angew Chem Int Ed Engl. 2007;46:8171-8173.
19. Spuentrup E, Ruhl KM, Botnar RM, Wiethoff AJ, Buhl A, Jacques V, Greenfield MT, Krombach GA, Gunther RW, Vangel MG, Caravan P. Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: initial feasibility study in a swine model. Circulation. 2009;119:1768-1775.
20. Li SH, Sun Z, Guo L, Han M, Wood MF, Ghosh N, Vitkin IA, Weisel RD, Li RK. Elastin overexpression by cell-based gene therapy preserves matrix and prevents cardiac dilation. J Cell Mol Med. 2012;16:2429-2439.
21. Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, Bundy J, Finn JP, Klocke FJ, Judd RM. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation. 1999;100:1992-2002.
22. Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, Finn JP, Judd RM. An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001;218:215-223.
23. Coolen BF, Geelen T, Paulis LE, Nicolay K, Strijkers GJ. Regional contrast agent quantification in a mouse model of myocardial infarction using 3D cardiac T1 mapping. J Cardiovasc Magn Reson. 2011;13:56.
24. von Bary C, Makowski M, Preissel A, Keithahn A, Warley A, Spuentrup E, Buecker A, Lazewatsky J, Cesati R, Onthank D, Schickl N, Schachoff S, Hausleiter J, Schomig A, Schwaiger M, Robinson S, Botnar R. MRI of coronary wall remodeling in a swine model of coronary injury using an elastin-binding contrast agent. Circ Cardiovasc Imaging. 2011;4:147-155.
25. Ehling J, Bartneck M, Fech V, Butzbach B, Cesati R, Botnar R, Lammers T, Tacke F. Elastin-based molecular MRI of liver fibrosis. Hepatology. 2013;58:1517-1518.
26. Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M. Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J Clin Invest. 2010;120:2627-2634.
27. Sun M, Chen M, Liu Y, Fukuoka M, Zhou K, Li G, Dawood F, Gramolini A, Liu PP. Cathepsin-L contributes to cardiac repair and remodelling post-infarction. Cardiovasc Res. 2011;89:374-383.
28. van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, Marshall WS, Hill JA, Olson EN. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A. 2008;105:13027-13032.
29. Shioura KM, Geenen DL, Goldspink PH. Sex-related changes in cardiac function following myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol. 2008;295:R528-R534.
30. Wang F, Keimig T, He Q, Ding J, Zhang Z, Pourabdollah-Nejad S, Yang XP. Augmented healing process in female mice with acute myocardial infarction. Gend Med. 2007;4:230-247.
31. Wu JC, Nasseri BA, Bloch KD, Picard MH, Scherrer-Crosbie M. Influence of sex on ventricular remodeling after myocardial infarction in mice. J Am Soc Echocardiogr. 2003;16:1158-1162.
32. Cavasin MA, Tao ZY, Yu AL, Yang XP. Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function. Am J Physiol Heart Circ Physiol. 2006;290:H2043-H2050.
33. Gao XM, Xu Q, Kiriazis H, Dart AM, Du XJ. Mouse model of post-infarct ventricular rupture: time course, strain-and gender-dependency, tensile strength, and histopathology. Cardiovasc Res. 2005;65:469-477.