Overexpression of elastin fragments in infarcted myocardium attenuates scar expansion and heart dysfunction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 6 57-6, 2005, Pages

  Mizuno, Tomohiro ^a   Mickle, Donald A G ^a   Kiani, Chris G ^a   Li, Ren Ke ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

^c HEART AND STROKE FOUNDATION OF CANADA   (Canada)

Author keywords

Cell transplantation; Gene therapy; Myocardial infarction; Ventricular modulation

Indexed keywords

ELASTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; CONTROLLED STUDY; ELASTICITY; EXTRACELLULAR MATRIX; HEART DILATATION; HEART INFARCTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HISTOPATHOLOGY; IN VIVO STUDY; MALE; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCAR FORMATION; TENSILE STRENGTH; WESTERN BLOTTING;

ANIMALS; AORTA; BASE SEQUENCE; CERCOPITHECUS AETHIOPS; CICATRIX; COS CELLS; DNA PRIMERS; ELASTIN; EXTRACELLULAR MATRIX; GENETIC VECTORS; HEART; MYOCARDIAL INFARCTION; PEPTIDE FRAGMENTS; RATS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 19344363862     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00862.2004     Document Type: Article

References (20)

1. Akhyari P, Fedak PWM, Weisel RD, Lee JYJ, Verma S, Mickle DAG, and Li RK. Mechanical stretch regimen enhances the formation of bioengineered autologous cardiac muscle grafts. Circulation 106, Suppl I: I-137-I-142, 2002.
2. Forrest L and Jackson DS. Intermolecular crosslinking of collagen in human and guinea pig scar tissue. Biochim Biophys Acta 229: 681-689, 1971.
3. Ghostine S, Carrion C, Souza LC, Richard P, Bruneval P, Vilquin JT, Pouzet B, Schwartz K, Menasche P, and Hagege AA. Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction. Circulation 106: I-131-I-136, 2002.
4. Gupta KB, Ratcliffe MB, Fallert MA, Edmunds LH Jr, and Bogen DK. Changes in passive mechanical stiffness of myocardial tissue with aneurysm formation. Circulation 89: 2315-2326, 1994.
5. Keeley FW, Bellingham CM, and Woodhouse KA. Elastin as a self-organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin. Philos Trans R Soc Lond B Biol Sci 357: 185-189, 2002.
6. Kielty CM, Sherratt MJ, and Shuttleworth CA. Elastic fibres. J Cell Sci 115: 2817-2828, 2002.
7. Li DY, Brooke B, Davis EC, Mecham RP, Sorensen LK, Boak BB, Eichwald E, and Keating MT. Elastin is an essential determinant of arterial morphogenesis. Nature 393: 276-280, 1998.
8. Li RK, Jia ZQ, Weisel RD, Mickle DAG, Zhang J, Mohabeer MK, Rao V, and Ivanov J. Cardiomyocyte transplantation improves heart function. Ann Thorac Surg 62: 654-661, 1996.
9. Markovitz LJ, Savage EB, Ratcliffe MB, Bavaria JE, Kreiner G, Iozzo RV, Hargrove WC 3rd, Bogen DK, and Edmunds LH Jr. Large animal model of left ventricular aneurysm. Ann Thorac Surg 48: 838-845, 1989.
10. Muller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI, Laird PW, and Kedes L. Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol 34: 107-116, 2002.
11. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J Jr, Honjo T, and Chien KR. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature 415: 171-175, 2002.
12. Parmley WW, Chuck L, Kivowitz C, Matloff JM, and Swan HJ. In vitro length-tension relations of human ventricular aneurysms: relation of stiffness to mechanical disadvantage. Am J Cardiol 32: 889-894, 1973.
13. Pereira L, Lee SY, Gayraud B, Andrikopoulos K, Shapiro SD, Bunton T, Biery NJ, Dietz HC, Sakai LY, and Ramirez F. Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proc Natl Acad Sci USA 96: 3819-3823, 1999.
14. Pfeffer JM, Pfeffer MA, Fletcher PJ, and Braunwald E. Progressive ventricular remodeling-in rat with myocardial infarction. Am J Physiol Heart Circ Physiol 260: H1406-H1414, 1991.
15. Pfeffer MA and Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 81: 1161-1172, 1990.
16. Raya TE, Gay RG, Lancaster L, Aguirre M, Moffett C, and Goldman S. Serial changes in left ventricular relaxation and chamber stiffness after large myocardial infarction in rats. Circulation 77: 1424-1431, 1988.
17. Tomita S, Li RK, Weisel RD, Mickle DAG, and Jia ZQ. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100: II-247-II-256, 1999.
18. White HD, Morris RM, Brown MA, Brandt PW, Whitlock RM, and Wild CJ. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation 76: 44-51, 1987.
19. Yanagisawa H, Davis EC, Starcher BC, Ouchi T, Yanagisawa M, Richardson JA, and Olson EN. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature 415: 168-171, 2002.
20. Yoo KY, Li RK, Weisel RD, Mickle DAG, Li GM, Kim EJ, Tomita S, and Yau TM. Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy. Ann Thorac Surg 70: 859-865. 2000.