Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 290, Issue 5, 2006, Pages

  Cavasin, Maria A ^a,c   Tao, Zhen Yin ^b   Yu, Ai Li ^a   Yang, Xiao Ping ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c HENRY FORD HOSPITAL   (United States)

Author keywords

Hormone manipulation; Infarct expansion index; Left ventricle; Neutrophil infiltration

Indexed keywords

ESTRADIOL; PLACEBO; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; FEMALE; HEART FUNCTION; HEART INFARCTION; HEART RUPTURE; HEART VENTRICLE REMODELING; HEART WEIGHT; HISTOLOGY; MALE; MORPHOLOGY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; TRANSTHORACIC ECHOCARDIOGRAPHY;

ANIMALS; CASTRATION; FEMALE; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIUM; OVARIECTOMY; RUPTURE; SEX FACTORS; SURVIVAL RATE; TESTOSTERONE; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 33646426102     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01121.2005     Document Type: Article

References (26)

1. Ashcroft GS, Dodsworth J, van Boxtel E, Tarnuzzer RW, Horan MA, Schultz GS, and Ferguson MWJ. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels. Nat Med 3: 1209-1215, 1997.
2. Becker RC, Gore JM, Lambrew C, Weaver WD, Rubison RM, French WJ, Tiefenbrunn AJ, Bowlby LJ, and Rogers WJ for the National Registry of Myocardial Infarction participants. A composite view of cardiac rupture in the United States National Registry of Myocardial Infarction. J Am Coll Cardiol 27: 1321-1326, 1996.
3. Cavasin MA, Sankey SS, Yu A-L, Menon S, and Yang X-P. Estrogen and testosterone have opposing effects on chronic cardiac remodeling and function in mice with myocardial infarction. Am J Physiol Heart Circ Physiol 284: H1560-H1569, 2003.
4. Cavasin MA, Tao Z, Menon S, and Yang X-P. Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice. Life Sci 75: 2181-2192, 2004.
5. 1 antagonist, and combined treatment in mice with heart failure. J Cardiovasc Pharmacol 36: 472-480, 2000.
6. Ertl G and Frantz S. Healing after myocardial infarction. Cardiovasc Res 66: 22-32, 2005.
7. Gao X-M, Xu Q, Kiriazis H, Dart AM, and Du XJ. Mouse model of post-infarct ventricular rupture: time course, strain- and gender-dependency, tensile strength, and histopathology. Cardiovasc Res 65: 469-477, 2005.
8. Gaudron P, Kugler I, Hu K, Bauer W, Eilles C, and Ertl G. Time course of cardiac structural, functional and electrical changes in asymptomatic patients after myocardial infarction: their inter-relation and prognostic impact. J Am Coll Cardiol 38: 33-40, 2001.
9. Hutchins KD, Skurnick J, Lavenhar M, and Natarajan GA. Cardiac rupture in acute myocardial infarction: a reassessment. Am J Forensic Med Pathol 23: 78-82, 2002.
10. Iwahashi M, Ooshima A, and Nakano R. Effects of oestrogen on the extracellular matrix in the endometrium of postmenopausal women. J Clin Pathol 50: 755-759, 1997.
11. Junqueira LC and Carneiro J. Blood cells. In: Basic Histology, edited by Junqueira LC and Carneiro J. Los Altos, CA: Lange Medical Publications, 1983, p. 259-273.
12. Lee H-W and Eghbali-Webb M. Estrogen enhances proliferative capacity of cardiac fibroblasts by estrogen receptor- and mitogen-activated protein kinase-dependent pathways. J Mol Cell Cardiol 30: 1359-1368, 1998.
13. Lindsey M, Wedin K, Brown MD, Keller C, Evans AJ, Smolen J, Burns AR, Rossen RD, Michael L, and Entman M. Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion. Circulation 103: 2181-2187, 2001.
14. Litwin SE, Katz SE, Litwin CM, Morgan JP, and Douglas PS. Gender differences in postinfarction left ventricular remodeling. Cardiology 91: 173-183, 1999.
15. Liu Y-H, Yang X-P, Nass O, Sabbah HN, Peterson E, and Carretero OA. Chronic heart failure induced by coronary artery ligation in Lewis inbred rats. Am J Physiol Heart Circ Physiol 272: H722-H727, 1997.
16. MacGregor JI and Jordan VC. Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 50: 151-196, 1998.
17. Madri JA. Inflammation and healing. In: Anderson's Pathology, edited by Kissane JM. St. Louis, MO: Mosby, 1990, vol. 1, p. 67-110.
18. Matsumura S, Iwanaga S, Mochizuki S, Okamoto H, Ogawa S, and Okada Y. Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice. J Clin Invest 115: 599-609, 2005.
19. Rasmussen S, Leth A, Kjoller E, and Pedersen A. Cardiac rupture in acute myocardial infarction: a review of 72 consecutive cases. Acta Med Scand 205: 11-16, 1979.
20. Reardon MJ, Carr CL, Diamond A, Letsou GV, Safi HJ, Espada R, and Baldwin JC. Ischemic left ventricular free wall rupture: prediction, diagnosis, and treatment. Ann Thorac Surg 64: 1509-1513, 1997.
21. Shapira I, Isakov A, Burke M, and Almog C. Cardiac rupture in patients with acute myocardial infarction. Chest 92: 219-223, 1987.
22. Tao Z-Y, Cavasin MA, Yang F, Liu Y-H, and Yang X-P. Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice. Life Sci 74: 1561-1572, 2004.
23. Tyagi SC, Campbell SE, Reddy HK, Tjahja E, and Voelker DJ. Matrix metalloproteinase activity expression in infarcted, noninfarcted and dilated cardiomyopathic human hearts. Mol Cell Biochem 155: 13-21, 1996.
24. Wang M, Tsai BM, Kher A, Baker LB, Wairiuko GM, and Meldrum DR. Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion. Am J Physiol Heart Circ Physiol 288: H221-H226, 2005.
25. 2 kinin receptor gene knockout mice. Circ Res 88: 1072-1079, 2001.
26. Yang X-P, Liu Y-H, Rhaleb N-E, Kurihara N, Kim HE, and Carretero OA. Echocardiographic assessment of cardiac function in conscious and anesthetized mice. Am J Physiol Heart Circ Physiol 277: H1967-H1974, 1999.