Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice

Journal of Clinical Investigation

Volumn 120, Issue 7, 2010, Pages 2627-2634

  Swirski, Filip K ^a   Wildgruber, Moritz ^a   Ueno, Takuya ^a   Figueiredo, Jose Luiz ^a   Panizzi, Peter ^a   Iwamoto, Yoshiko ^a   Zhang, Elizabeth ^a   Stone, James R ^a   Rodriguez, Elisenda ^a   Chen, John W ^a   Pittet, Mikael J ^a   Weissleder, Ralph ^a   Nahrendorf, Matthias ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GADOLINIUM CHELATE; MYELOPEROXIDASE; PEROXIDASE;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; GRAFT REJECTION; HEART TRANSPLANTATION; INFLAMMATION; ISOGRAFT; MONOCYTE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DIAGNOSTIC IMAGING; IMMUNOLOGY; LEUKOCYTE COUNT; MOUSE MUTANT; NEUTROPHIL; PATHOLOGY; PHYSIOLOGY;

ANIMALS; DIAGNOSTIC IMAGING; FLOW CYTOMETRY; GRAFT REJECTION; HEART TRANSPLANTATION; LEUKOCYTE COUNT; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; MYELOID CELLS; NEUTROPHILS; PEROXIDASE; TRANSPLANTATION, ISOGENEIC;

EID: 77954969581     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI42304     Document Type: Article

References (30)

1. Miniati DN, Robbins RC. Heart transplantation: a thirty-year perspective. Annu Rev Med. 2002;53:189-205.
2. Kubo SH, et al. Risk factors for late recurrent rejection after heart transplantation: a multiinstitutional, multivariable analysis. Cardiac Transplant Research Database Group. J Heart Lung Transplant. 1995;14(3):409-418.
3. Gradek WQ, D'Amico C, Smith AL, Vega D, Book WM. Routine surveillance endomyocardial biopsy continues to detect significant rejection late after heart transplantation. J Heart Lung Transplant. 2001;20(5):497-502.
4. Tucker PA 2nd, Jin BS, Gaos CM, Radovancevic B, Frazier OH, Wilansky S. Flail tricuspid leaflet after multiple biopsies following orthotopic heart transplantation: echocardiographic and hemodynamic correlation. J Heart Lung Transplant. 1994;13(3):466-472.
5. Swirski FK, et al. Ly-6Chi monocytes dominate hypercholesterolemia- associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007;117(1):195-205.
6. Tacke F, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest. 2007;117(1):185-194.
7. Swirski FK, Weissleder R, Pittet MJ. Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29(10):1424-1432.
8. Nahrendorf M, et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204(12):3037-3047.
9. Auffray C, et al. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med. 2009;206(3):595-606.
10. Serbina NV, Salazar-Mather TP, Biron CA, Kuziel WA, Pamer EG. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity. 2003;19(1):59-70.
11. Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003;19(1):71-82.
12. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5(12):953-964.
13. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol. 2007;81(3):584-592.
14. Sunderkotter C, et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol. 2004;172(7):4410-4417.
15. Hancock WW, Thomson NM, Atkins RC. Composition of interstitial cellular infiltrate identified by monoclonal antibodies in renal biopsies of rejecting human renal allografts. Transplantation. 1983;35(5):458-463.
16. Christen T, et al. Molecular imaging of innate immune cell function in transplant rejection. Circulation. 2009;119(14):1925-1932.
17. Girlanda R, et al. Monocyte infiltration and kidney allograft dysfunction during acute rejection. Am J Transplant. 2008;8(3):600-607.
18. Swirski FK, et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009;325(5940):612-616.
19. Chen JW, Querol Sans M, Bogdanov A Jr, Weissleder R. Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology. 2006;240(2):473-481.
20. Nahrendorf M, et al. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008;117(9):1153-1160.
21. Yang Z, Berr SS, Gilson WD, Toufektsian MC, French BA. Simultaneous evaluation of infarct size and cardiac function in intact mice by contrast-enhanced cardiac magnetic resonance imaging reveals contractile dysfunction in noninfarcted regions early after myocardial infarction. Circulation. 2004;109(9):1161-1167.
22. Stewart S, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24(11):1710-1720.
23. Narula J, et al. Annexin-V imaging for noninvasive detection of cardiac allograft rejection. Nat Med. 2001;7(12):1347-1352.
24. Frist W, et al. Noninvasive detection of human cardiac transplant rejection with indium-111 antimyosin (Fab) imaging. Circulation. 1987;76(5 pt 2):V81-V85.
25. Kanno S, et al. Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall super-paramagnetic iron oxide particles. Circulation. 2001;104(8):934-938.
26. Aherne T, et al. Magnetic resonance imaging of cardiac transplants: the evaluation of rejection of cardiac allografts with and without immunosuppression. Circulation. 1986;74(1):145-156.
27. Wu YL, et al. In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc Natl Acad Sci U S A. 2006;103(6):1852-1857.
28. Gabrilovich DI, Ngaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9(3):162-174.
29. Jose MD, Ikezumi Y, van Rooijen N, Atkins RC, Chadban SJ. Macrophages act as effectors of tissue damage in acute renal allograft rejection. Transplantation. 2003;76(7):1015-1022.
30. Wyburn KR, Jose MD, Wu H, Atkins RC, Chadban SJ. The role of macrophages in allograft rejection. Transplantation. 2005;80(12):1641-1647.