Self-reporter shikonin-Act-loaded solid lipid nanoparticle: Formulation, physicochemical characterization and geno/cytotoxicity evaluation

European Journal of Pharmaceutical Sciences

Volumn 59, Issue 1, 2014, Pages 49-57

  Eskandani, Morteza ^a,b   Nazemiyeh, Hossein ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acetylshikonin; Bio distribution imaging; Cytotoxicity; Drug delivery; Genotoxicity; Solid lipid nanoparticle

Indexed keywords

ACETYLSHIKONIN; ECHIUM ITALICUM EXTRACT; PLANT EXTRACT; SHIKONIN DERIVATIVE; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; DIACYLGLYCEROL; DRUG CARRIER; GLYCEROL PALMITOSTEARATE; NANOPARTICLE; POLYSORBATE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DIFFUSION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; EPITHELIAL CANCER CELL LINE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LASER DIFFRACTION; LUNG CARCINOMA; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; CELL PROLIFERATION; CHEMISTRY; COMET ASSAY; DRUG EFFECTS; MALE; MEDICINAL CHEMISTRY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; COMET ASSAY; DIGLYCERIDES; DRUG CARRIERS; DRUG STABILITY; HUMANS; MALE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; POLYSORBATES; RATS, SPRAGUE-DAWLEY;

EID: 84900395858     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.04.009     Document Type: Article

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