Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in Lewis lung carcinoma-bearing mice

Yakugaku Zasshi

Volumn 128, Issue 11, 2008, Pages 1681-1688

  Lee, Hyo Jung ^a   Lee, Hyo Jeong ^a   Magesh, Venkataraman ^a   Nam, Dongwoo ^a   Lee, Eun Ok ^a   Ahn, Kwang Seok ^a   Jung, Min Hyung ^b   Ahn, Kyoo Seok ^a   Kim, Dae Keun ^c   Kim, Ji Young ^a   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

^c Woosuk University   (South Korea)

Author keywords

Angiogenesis; Lithospermum erythrorhizon; Shikonin derivative; Vascular endothelial growth factor (VEGF)

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ACETYLSHIKONIN; ISOBUTYROYLSHIKONIN; PLANT EXTRACT; SHIKONIN; UNCLASSIFIED DRUG; UROKINASE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG INHIBITION; DRUG ISOLATION; DRUG STRUCTURE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IC 50; LUNG CARCINOMA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN EXPRESSION; TUMOR GROWTH; UMBILICAL VEIN;

ANIMALS; ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARCINOMA, LEWIS LUNG; CELL MOVEMENT; CELLS, CULTURED; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIAL CELLS; FEMALE; HUMANS; LITHOSPERMUM; MICE; NAPHTHOQUINONES; NEOVASCULARIZATION, PATHOLOGIC; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 56049098575     PISSN: 00316903     EISSN: 13475231     Source Type: Journal    
DOI: 10.1248/yakushi.128.1681     Document Type: Article

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