The influence of acetylshikonin, a natural naphthoquinone, on the production of leukotriene B4 and thromboxane A2 in rat neutrophils

European Journal of Pharmacology

Volumn 607, Issue 1-3, 2009, Pages 234-243

  Hsu, Mei Feng ^a   Chang, Ling Chu ^b   Huang, Li Jiau ^a   Kuo, Sheng Chu ^a   Lee, Hsiao Yun ^c   Lu, Min Chi ^b   Wang, Jih Pyang ^a,c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

5 Lipoxygenase; Acetylshikonin; Arachidonic acid release; Cytosolic phospholipase A2; Extracellular signal regulated kinase; Intracellular free Ca2+; Neutrophil

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLSHIKONIN; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CALCIMYCIN; CALCIUM; CYCLOOXYGENASE 1; CYTOSOLIC PHOSPHOLIPASE A2; DIHYDRORHODAMINE 123; FORMYLMETHIONYLLEUCYLPHENYLALANINE; ICOSANOID; INDOMETACIN; IONOMYCIN; LEUKOTRIENE B4; LINSIDOMINE; LIPID PEROXIDASE; MITOGEN ACTIVATED PROTEIN KINASE; NAPHTHOQUINONE; PEROXYNITRITE; PROSTAGLANDIN D2; THROMBOXANE A2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CELL FREE SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IC 50; LIPID PEROXIDATION; MAST CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; RAM (SHEEP); RAT; SCAVENGING SYSTEM; SEMINAL VESICLE;

ANIMALS; ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; CALCIMYCIN; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEUKOTRIENE B4; MALE; MICE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHOSPHOLIPASES A2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SEMINAL VESICLES; SHEEP; THROMBOXANE A2;

EID: 62149131823     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.02.005     Document Type: Article

References (38)

1. Albert D., Bürkert E., Steinhilber D., and Werz O. Induction of 5-lipoxygenase activation in polymorphonuclear leukocytes by 1-oleoyl-2-acetylglycerol. Biochim. Biophys. Acta 1631 (2003) 85-93
2. Berridge M.J., Bootman M.D., and Roderick H.L. Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev., Mol. Cell Biol. 4 (2003) 517-529
3. Borgeat P., and Samuelsson B. Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. J. Biol. Chem. 2554 (1979) 2643-2646
4. 2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets. Eur. J. Biochem. 245 (1997) 751-759
5. Celotti F., and Laufer S. Anti-inflammatory drugs: new multi-target compounds to face an old problem. The dual inhibition concept. Pharmacol. Res. 43 (2001) 429-436
6. Chang Y.S., Kuo S.C., Weng S.H., Jan S.C., Ko F.N., and Teng C.M. Inhibition of platelet aggregation by shikonin derivatives isolated from Arnebia euchroma. Plant. Med. 59 (1993) 401-404
7. Chen X.S., and Funk C.D. The N-terminal "β-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation. J. Biol. Chem. 276 (2001) 811-818
8. 2+-dependent translocation domain with homology to PKC and GAP. Cell 65 (1991) 1043-1051
9. Coffey M., Peters-Golden M., Fantone J.C., and Sporn P.H. Membrane association of active 5-lipoxygenase in resting cells: evidence for novel regulation of the enzyme in the rat alveolar macrophage. J. Biol. Chem. 267 (1992) 570-576
10. Cuenda A., and Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim. Biophys. Acta 1773 (2007) 1358-1375
11. De Gaetano G., Donati M.B., and Cerletti C. Prevention of thrombosis and vascular inflammation: benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors. Trends Pharmacol. Sci. 24 (2003) 245-252
12. 2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. J. Biol. Chem. 277 (2002) 5061-5073
13. 2 regulation. J. Biol. Chem. 275 (2000) 20146-20156
14. 2. Biochemistry 37 (1998) 8516-8526
15. Hsu M.F., Lu M.C., Tsao L.T., Kuan Y.H., Chen C.C., and Wang J.P. Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils. Biochem. Pharmacol. 67 (2004) 831-840
16. Hsu M.F., Lin C.N., Lu M.C., and Wang J.P. Inhibition of arachidonic acid cascade by norathyriol via the blockade of cyclooxygenase and lipoxygenase activity in neutrophils. Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (2004) 507-515
17. 2s. Biochim. Biophys. Acta 1761 (2006) 1317-1322
18. Kuehl F.A., and Egan R.W. Prostaglandins, arachidonic acid and inflammation. Science 210 (1980) 978-984
19. Majima R., and Kuroda C. The coloring matter of Lithospermum erythrorhizon. Acta Phytochem. 1 (1922) 43-65
20. Maloney C.G., Kutchera W.A., Albertine K.H., McIntyre T.M., Perscott S.M., and Zimmermann G.A. Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils. J. Immunol. 160 (1998) 1402-1410
21. 2 binds with high affinity and specificity to phosphatidylinositol 4,5-bisphosphate resulting in dramatic increases in activity. J. Biol. Chem. 273 (1998) 2184-2191
22. Motohide H. Pharmacological studies on crude plant drugs Shikon and Tooki. (II). Shikonin and acetylshikonin. Nippon Yakurigaku Zasshi 73 (1977) 193-203
23. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J. Biol. Chem. 268 (1993) 1960-1964
24. Putney J.W. Capacitative calcium entry revisited. Cell Calcium 11 (1990) 611-624
25. 2 in regulating arachidonic acid release in macrophages. J. Biol. Chem. 273 (1998) 8203-8211
26. Rådmark O., Werz O., Steinhilber D., and Samuelsson B. 5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem. Sci. 32 (2007) 332-341
27. Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220 (1983) 568-575
28. Samuelsson B. The discovery of the leukotrienes. Am. J. Respir. Crit. Care Med. 161 (2000) S2-S6
29. Schatz-Munding M., Hatzelmann A., and Ullrich V. The involvement of extracellular calcium in the formation of 5-lipoxygenase metabolites by human polymorphonuclear leukocytes. Eur. J. Biochem. 197 (1991) 487-493
30. Schildknecht S., Daiber A., Ghisla S., Cohen R.A., and Bachschmid M.M. Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite. FASEB J. 22 (2008) 215-224
31. Tintinger G., Steel H.C., and Anderson R. Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control. Clin. Exp. Immunol. 141 (2005) 191-200
32. Vane J.R. Prostaglandins as mediators of inflammation. Adv. Prostaglandin Thromboxane Res. 2 (1976) 791-801
33. Wang J.P., and Kuo S.C. Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils. Biochem. Pharmacol. 53 (1997) 1173-1177
34. Wang J.P., Hsu M.F., Raung S.L., Chen C.C., Kuo J.S., and Teng C.M. Anti-inflammatory and analgesic effects of magnolol. Naunyn-Schmiedeberg's Arch. Pharmacol. 346 (1992) 707-712
35. Wang J.P., Raung S.L., Chang L.C., and Kuo S.C. Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. Eur. J. Pharmacol. 272 (1995) 87-95
36. Wang J.P., Tsao L.T., Raung S.L., Hsu M.F., and Kuo S.C. Investigation of the inhibition by acetylshikonin of the respiratory burst in rat neutrophils. Br. J. Pharmacol. 121 (1997) 409-416
37. Werz O. 5-Lipoxygenase: cellular biology and molecular pharmacology. Curr. Drug Targets Inflamm. Allergy 1 (2002) 23-44
38. Werz O., Bürkert E., Fischer L., Szellas D., Dishart D., Samuelsson B., Rådmark O., and Steinhilber D. Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J. 16 (2002) 1441-1443