Emodin inhibits extracellular matrix synthesis by suppressing p38 and ERK1/2 pathways in TGF-β 1-stimulated NRK-49F cells

Molecular Medicine Reports

Volumn 4, Issue 3, 2011, Pages 505-509

  Zhu, Bin ^a   Lin, Yi ^a   Zhu, Cai Feng ^a   Zhu, Xiao Ling ^a   Huang, Chen Zhao ^a   Lu, Ying ^a   Cheng, Xiao Xia ^a   Wang, Yong Jun ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Emodin; Extracellular matrix; Mitogen activated protein kinase; Renal fibrosis

Indexed keywords

COLLAGEN TYPE 3; EMODIN; FIBRONECTIN; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE 3; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FIBROSIS; KIDNEY CELL; NONHUMAN; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

CELL DEATH; CELL LINE; COLLAGEN TYPE III; EMODIN; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; FIBRONECTINS; L-LACTATE DEHYDROGENASE; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79953803456     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.444     Document Type: Article

References (27)

1. Zhan Y, Li D, Wei H, et al: Emodin on hepatic fibrosis in rats. Chin Med J 113: 599-601, 2000.
2. Wang CH, Gao ZQ, Ye B, et al: Effect of emodin on pancreatic fibrosis in rats. World J Gastroenterol 13: 378-382, 2007. (Pubitemid 46178971)
3. Chen XH, Sun RS, Hu JM, et al: Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice. Clin Exp Pharmacol Physiol 36: 146-153, 2009.
4. Li X, Liu W, Wang Q, et al: Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose. Mol Cell Endocrinol 307: 157-162, 2009.
5. Wang R, Wan Q, Zhang Y, et al: Emodin suppresses interleukin-1beta induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK. Life Sci 80: 2481-2488, 2007. (Pubitemid 46818295)
6. Kutz SM, Hordines J, McKeown-Longo PJ and Higgins PJ: TGF-beta1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion. J Cell Sci 114: 3905-3914, 2001. (Pubitemid 33094705)
7. Seeker GA, Shortt AJ, Sampson E, Schwarz QP, Schultz GS and Daniels JT: TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling. Exp Cell Res 314: 131-142, 2008. (Pubitemid 350180781)
8. Nagai Y, Miyata K, Sun GP, et al: Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fbroblasts. Hypertension 46: 1039-1045, 2005.
9. Lin CL, Wang FS, Kuo YR, et al: Ras modulation of superoxide activates ERK-dependent fbronectin expression in diabetes-induced renal injuries. Kidney Int 69: 1593-1600, 2006.
10. Chin BY, Mohsenin A, Li SX, Choi AM and Choi ME: Stimulation of pro-alpha(1)(I) collagen by TGF-beta(1) in mesangial cells: role of the p38 MAPK pathway. Am J Physiol 280: F495-F504, 2001.
11. Niculescu-Duvaz I, Phanish MK, Colville-Nash P and Dockrell ME: The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent. Nephron Exp Nephrol 105: e108-e116, 2007. (Pubitemid 46496818)
12. Sekine S, Nitta K, Uchida K, Yumura W and Nihei H: Possible involvement of mitogen-activated protein kinase in the angiotensin II-induced fibronectin synthesis in renal interstitial fibroblasts. Arch Biochem Biophys 415: 63-68, 2003. (Pubitemid 36687917)
13. Rodriguez-Pena AB, Grande MT, Eleno N, et al: Activation of Erk1/2 and Akt following unilateral ureteral obstruction. Kidney Int 74: 196-209, 2008. (Pubitemid 351915085)
14. Stambe C, Atkins RC, Tesch GH, Masaki T, Schreiner GF and Nikolic-Paterson DJ: The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis. J Am Soc Nephrol 15: 370-379, 2004. (Pubitemid 38140777)
15. Ma FY, Flanc RS, Tesch GH, et al: A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol 18: 472-484, 2007. (Pubitemid 46193313)
16. Fraser D, Brunskill N, Ito T and Phillips A: Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop. Am J Pathol 163: 2565-2574, 2003. (Pubitemid 37466497)
17. Zhu B, Wang YJ, Zhu CF, et al: Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-{beta}1-stimulated NRK-49F cells. Nephrol Dial Transplant 25: 3180-3191, 2010.
18. Dong MX, Jia Y, Zhang YB, et al: Emodin protects rat liver from CC1(4)-induced fbrogenesis via inhibition of hepatic stellate cells activation. World J Gastroenterol 15: 4753-4762, 2009.
19. Gui M, Zhang YF, Xiao ZY, et al: Inhibitory effect of emodin on tissue inhibitor of metalloproteinases-1 (TIMP-1) expression in rat hepatic stellate cells. Dig Dis Sci 52: 200-207, 2007. (Pubitemid 46122067)
20. Lee J, Jung E, Huh S, et al: Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). Life Sci 79: 2480-2485, 2006. (Pubitemid 44794361)
21. Wang J, Huang H, Liu P, et al: Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats. Eur J Pharmacol 553: 297-303, 2006. (Pubitemid 44779584)
22. Hu Q, Noor M, Wong YF, et al: In vitro anti-fibrotic activities of herbal compounds and herbs. Nephrol Dial Transplant 24: 3033-3041, 2009.
23. Huang Q, Shen HM and Ong CN: Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol 68: 361-371, 2004. (Pubitemid 38757705)
24. Kitano A, Saika S, Yamanaka O, et al: Emodin suppression of ocular surface infammatory reaction. Invest Ophthalmol Vis Sci 48: 5013-5022, 2007. (Pubitemid 351260911)
25. Kim MS, Park MJ, Kim SJ, et al: Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells. Int J Oncol 27: 839-846, 2005.
26. Kwak HJ, Park MJ, Park CM, et al: Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation. Int J Cancer 118: 2711-2720, 2006.
27. Lu HF, Lai KC, Hsu SC, et al: Involvement of matrix meta1-loproteinases on the inhibition of cells invasion and migration by emodin in human neuroblastoma SH-SY5Y cells. Neurochem Res 34: 1575-1583, 2009.