The potential role of increasing the release of mouse β-defensin-14 in the treatment of osteomyelitis in mice: A primary study

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Zhu, Chen ^a,b   Wang, Jiaxing ^a   Cheng, Tao ^a   Li, Qingtian ^a   Shen, Hao ^a   Qin, Hui ^a   Cheng, Mengqi ^a   Zhang, Xianlong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ANISOMYCIN; BETA DEFENSIN; BETA DEFENSIN 14; COLLAGEN TYPE 1; OSTEOCALCIN; UNCLASSIFIED DRUG; BETA-DEFENSIN 3, HUMAN; BETA-DEFENSIN-14, MOUSE; HEMOGLOBIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BODY WEIGHT; CLINICAL ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE COUNT; LIMIT OF DETECTION; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; OPTICAL DENSITY; OSTEOMYELITIS; PERIPROSTHETIC JOINT INFECTION; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNOVIUM; TOTAL HIP PROSTHESIS; ANIMAL; BACTERIAL COUNT; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; OSTEOBLAST; PATHOLOGY; SURGERY; TIBIA; WESTERN BLOTTING;

ANIMALS; BETA-DEFENSINS; BLOTTING, WESTERN; BODY TEMPERATURE; BODY WEIGHT; COLONY COUNT, MICROBIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HEMOGLOBINS; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOCYTE COUNT; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; OSTEOBLASTS; OSTEOMYELITIS; REAL-TIME POLYMERASE CHAIN REACTION; TIBIA;

EID: 84900299028     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086874     Document Type: Article

References (56)

1. Lew DP, Waldvogel FA (1997) Osteomyelitis. N Engl J Med 336: 999-1007.
2. Lention JR (2003) Prosthetic joint infections: bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis 36: 1157-1161.
3. Rolo J, Miragaia M, Turlej-Rogacka A, Empel J, Bouchami O, et al. (2012) High genetic diversity among community-associated Staphylococcus aureus in Europe: results from a multicenter study. PLoS One 7: e34768.
4. Montanaro L, Speziale P, Campoccia D, Ravaioli S, Cangini I, et al. (2011) Scenery of Staphylococcus implant infections in orthopedics. Future Microbiol 6: 1329-1349.
5. Cunningham R, Cockayne A, Humphreys H (1996) Clinical and molecular aspects of the pathogenesis of Staphylococcus aureus bone and joint infections. J Med Microbiol 44: 157-164. (Pubitemid 26101536)
6. Campoccia D, Montanaro L, Speziale P, Arciola CR (2010) Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use. Biomaterials 31: 6363-6377.
7. Shi Z, Neoh KG, Kang ET, Poh C, Wang W (2009) Titanium with surface-grafted dextran and immobilized bone morphogenetic protein-2 for inhibition of bacterial adhesion and enhancement of osteoblast functions. Tissue Eng Part A 15: 417-426.
8. Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, et al. (2010) Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 10: 597-602.
9. Espadinha D, Faria NA, Miragaia M, Lito LM, Melo-Cristino J, et al. (2013) Extensive dissemination of methicillin-resistant Staphylococcus aureus (MRSA) between the hospital and the community in a country with a high prevalence of nosocomial MRSA. PLoS One 8: e59960.
10. Hancock RE (2005) Mechanism of action of newer antibiotics for gram-positive pathogens. Lancet Infect Dis 5: 209-218.
11. Pazgier M, Hoover DM, Yang D, Lu W, Lubkowski J (2006) Human beta-defensins. Cell Mol Life Sci 63: 1294-1313.
12. Warnke PH, Springer IN, Russo PA, Wiltfang J, Essig H, et al. (2006) Innate immunity in human bone. Bone 38: 400-408. (Pubitemid 43255435)
13. Maisetta G, Batoni G, Esin S, Florio W, Bottai D, et al. (2006) In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Antimicrob Agents Chemother 50: 806-809. (Pubitemid 43191008)
14. Zhu C, Tan H, Cheng T, Shen H, Shao J, et al. (2013) Human β-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation. J Surg Res 183: 204-213.
15. Zhu C, He N, Cheng T, Tan H, Guo Y, et al. (2013) Ultrasound-targeted microbubble destruction enhances human β-defensin 3 activity against antibiotic-resistant staphylococcus biofilms. Inflammation 36: 983-996.
16. Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, et al. (2002) Identifi- cation of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. J Immunol 169: 2516-2523. (Pubitemid 34920996)
17. Hinrichsen K, Podschun R, Schubert S, Schröder JM, Harder J, et al. (2008) Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3. Antimicrob Agents Chemother 52: 1876-1879. (Pubitemid 351614694)
18. Röhrl J, Yang D, Oppenheim JJ, Hehlgans T (2008) Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta- defensin 3. J Biol Chem 283: 5414-5419.
19. Zhu C, Qin H, Cheng T, Tan HL, Guo YY, et al. (2013) Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways. Int J Mol Med 31: 1484-1494.
20. Xing F, Yu Z, Liu J, Di J, Zeng S, et al. (2008) Anisomycin inhibits the behaviors of T cells and the allogeneic skin transplantation in mice. J Immunother 31: 858-870.
21. Kochi SK, Collier RJ (1993) DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis. Exp Cell Res 208: 296-302. (Pubitemid 23274516)
22. Condorelli G, Trencia A, Vigliotta G, Perfetti A, Goglia U, et al. (2002) Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti- apoptotic function. J Biol Chem 277: 11013-11018. (Pubitemid 34952858)
23. Barrientos RM, O'Reilly RC, Rudy JW (2002) Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration. Behav Brain Res 134: 299-306. (Pubitemid 34912710)
24. Baumbauer KM, Young EE, Hoy KC Jr, France JL, Joynes RL (2006) Intrathecal infusions of anisomycin impact the learning deficit but not the learning effect observed in spinal rats that have received instrumental training. Behav Brain Res 173: 299-309. (Pubitemid 44291834)
25. Bernardi RE, Lattal KM, Berger SP (2007) Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Behav Neurosci 121: 156-163. (Pubitemid 46328634)
26. Li JY, huang JY, Li M, Zhang H, Xing B, et al. (2012) Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro. Acta Pharmacol Sin 33: 935-940.
27. Widaa A, Claro T, Foster TJ, O'Brien FJ, Kerrigan SW (2012) Staphylococcus aureus protein A plays a critical role in mediating bone destruction and loss in bone osteomyelitis. PLoS One 7: e40586.
28. Khatiwala CB, Peyton SR, Metzke M, Putnam AJ (2007) The regulation of osteogenesis by ECM rigidity in MC3T3-E1 cells requires MAPK activation. J Cell Physiol 211: 661-672. (Pubitemid 46683034)
29. Kapur S, Baylink DJ, Lau KH (2003) Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. Bone 32: 241-251. (Pubitemid 36349527)
30. Klees RF, Salasznyk RM, Kingsley K, Williams WA, Boskey A, et al. (2005) Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway. Mol Biol Cell 16: 881-890. (Pubitemid 40165579)
31. Nihonyanagi S, Kanoh Y, Okada K, Uozumi T, Kazuyama Y, et al. (2012) Clinical usefulness of multiplex PCR lateral flow in MRSA detection: a novel, rapid genetic testing method. Inflammation 35: 927-934.
32. Lucke M, Schmidmaier G, Sadoni S, Wildemann B, Schiller R, et al. (2003) Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats. Bone 32: 521-531. (Pubitemid 39665711)
33. Varoga D, Wruck CJ, Tohidnezhad M, Brandenburg L, Paulsen F, et al. (2009) Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3. Histochem Cell Biol 131: 207-218.
34. Ren W, Yang SY, Wooley PH (2004) A novel murine model of orthopaedic wear-debris associated osteolysis. Scand J Rheumatol 33: 349-357. (Pubitemid 39421221)
35. Hein-Kristensen L, Jørgensen MJ, Ravn H, Wiese L, Kurtzhals J, et al. (2010) Simultaneous administration of vitamin A and DTP vaccine modulates the immune response in a murine cerebral malaria model. Scand J Immunol 72: 302-308.
36. Pan X, Mao X, Cheng T, Peng X, Zhang X, et al. (2012) Up-regulated expression of MIF by interfacial membrane fibroblasts and macrophages around aseptically loosened implants. J Surg Res 176: 484-489.
37. Paulsen F, Pufe T, Conradi L, Varoga D, Tsokos M, et al. (2002) Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes. J Pathol 198: 369-377. (Pubitemid 35277388)
38. Ahrens K, Schunck M, Podda GF, Meingassner J, Stuetz A, et al. (2011) Mechanical and metabolic injury to the skin barrier leads to increased expression of murine β-defensin-1, -3, and -14. J Invest Dermatol 131: 443-452.
39. Tan H, Peng Z, Li Q, Xu X, Guo S, et al. (2012) The use of quaternised chitosan- loaded PMMA to inhibit biofilm formation and downregulate the virulence- associated gene expression of antibiotic-resistant staphylococcus. Biomaterials 33: 365-377.
40. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
41. Littlewood-Evans AJ, Hattenberger MR, Lüscher C, Pataki A, Zak O, et al. (1997) Local expression of tumor necrosis factor alpha in an experimental model of acute osteomyelitis in rats. Infect Immun 65: 3438-3443. (Pubitemid 27342433)
42. Ganz T, Lehrer RI (1995) Defensins. Pharmacol Ther 66: 191-205.
43. Lehrer RI, Barton A, Daher KA, Harwig SS, Ganz T, et al. (1989) Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest 84: 553-561. (Pubitemid 19196987)
44. Hoover DM, Rajashankar KR, Blumenthal R, Puri A, Oppenheim JJ, et al. (2000) The structure of human β-defensin-2 shows evidence of higher order oligomeri- zation. J Biol Chem 275: 32911-32918.
45. Menzies BE, Kenoyer A (2006) Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun 74: 6847-6854. (Pubitemid 44913160)
46. Röhrl J, Yang D, Oppenheim JJ, Hehlgans T (2010) Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. J Immunol 184: 6688-6694.
47. Funderburg N, Lederman MM, Feng Z, Drage MG, Jadlowsky J, et al. (2007) Human beta-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proc Natl Acad Sci USA 104: 18631-18635. (Pubitemid 350210748)
48. Presicce P,Giannelli S,Taddeo A,Villa ML, Della Bella S (2009) Human defensins activate monocyte-derived dendritic cells, promote the production of pro- inflammatory cytokines, and up-regulate the surface expression of CD91. J Leukoc Biol 86: 941-948.
49. Yu TC, Liu Y, Tan Y, Jiang Y, Zheng X, et al. (2004) Shock waves increase T-cell proliferation or IL-2 expression by activating p38 MAP kinase. Acta Biochim Biophys Sin 36: 741-748. (Pubitemid 40395039)
50. Kim JM, White JM, Shaw AS, Sleckman BP (2005) MAPK p38 alpha is dispensable for lymphocyte development and proliferation. J Immunol 174: 1239-1244.
51. Ma GF, Ali A, Verzijl N, et al. (2006) Increased collagen degradation around loosened total hip replacement implants. Arthritis Rheum 54: 2928-2933. (Pubitemid 44497772)
52. Walakovits LA, Moore VL, Bhardwaj N, Gallick GS, Lark MW (1992) Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury. Arthritis Rheum 35: 35-42.
53. Yoshida K, Kobayashi K, Yamagata N, Iwabuchi H, Katsura T, et al. (1992) Inflammatory cytokines and enzymes in synovial fluid of patients with rheumatoid arthritis and other arthritis. Int Arch Allergy Immunol 98: 286-292.
54. Lippross S, Klueter T, Steubesand N, Oestern S, Mentlein R, et al. (2012) Multiple trauma induces serum production of host defence peptides. Injury 43: 137-142.
55. Liberatore M, Pala A, Scaccianoce S, Anagnostou C, Di Tondo U, et al. (2009) Microbial targeting of 99 mTc-labeled recombinant human beta-defensin-3 in an animal model of infection: a feasibility pilot study. J Nucl Med 50: 823-826.
56. F. Yurt Lambrecht, O Yilmaz, P Unak, B Seyitoglu, K Durkan, et al. (2008) Imaging of bacterial infection with 99 m Tc-labeled HBD-1. J Radioanal Nucl Ch 277: 555-559.