Multiple trauma induces serum production of host defence peptides

Injury

Volumn 43, Issue 2, 2012, Pages 137-142

  Lippross, Sebastian ^a   Klueter, Tim ^a   Steubesand, Nadine ^a   Oestern, Stefanie ^a   Mentlein, Rolf ^b   Hildebrandt, Frank ^c   Podschun, Rainer ^a   Pufe, Thomas ^d   Seekamp, Andreas ^a   Varoga, Deike ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Antimicrobial peptides; Cathelicidin; Human beta defensin; Polytrauma; Trauma surgery

Indexed keywords

BETA DEFENSIN 2; BETA DEFENSIN 3; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; GAMMA INTERFERON; INTERLEUKIN 6;

ADOLESCENT; ADULT; AGED; ANTIBACTERIAL ACTIVITY; ARTICLE; BLOOD ANALYSIS; COMPLEMENT SYSTEM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; IMMUNOSTIMULATION; INHIBITION KINETICS; MALE; MULTIPLE TRAUMA; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN DETERMINATION; ULTRAFILTRATION;

ADOLESCENT; ADULT; AGED; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; BLOOD DONORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-6; MALE; MIDDLE AGED; MULTIPLE TRAUMA; SEPSIS; YOUNG ADULT;

EID: 84855827374     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/j.injury.2011.03.044     Document Type: Article

References (33)

1. M. Keel, and O. Trentz Pathophysiology of polytrauma Injury 36 6 2005 691 709 (Pubitemid 40732303)
2. A. Lenz, G.A. Franklin, and W.G. Cheadle Systemic inflammation after trauma Injury 38 12 2007 1336 1345 (Pubitemid 350192404)
3. N. Smith, D. Weyman, and G. Findlay The management of trauma victims in England and wales: a study by the national confidential enquiry into patient outcome and death Eur J Cardiothorac Surg 36 2 2009 340 343
4. R. Baccala, R. Gonzalez-Quintial, and B.R. Lawson Sensors of the innate immune system: their mode of action Nat Rev Rheumatol 5 8 2009 448 456
5. S.B. Flohe, J.M. Bangen, and S. Flohe Origin of immunomodulation after soft tissue trauma: potential involvement of extracellular heat-shock proteins Shock 27 5 2007 494 502 (Pubitemid 46626076)
6. A. Oberholzer, M. Keel, and R. Zellweger Incidence of septic complications and multiple organ failure in severely injured patients is sex specific J Trauma 48 5 2000 932 937 (Pubitemid 30435962)
7. C. Probst, B.A. Zelle, and N.A. Sittaro Late death after multiple severe trauma: when does it occur and what are the causes? J Trauma 66 4 2009 1212 1217
8. M. Zasloff Antimicrobial peptides of multicellular organisms Nature 415 January (6870) 2002 389 395 (Pubitemid 34100944)
9. J. Harder, J. Bartels, E. Christophers, and J.M. Schroder Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic J Biol Chem 276 February (8) 2001 5707 5713
10. J. Harder, J. Bartels, E. Christophers, and J.M. Schroder A peptide antibiotic from human skin Nature 387 June (6636) 1997 861
11. D. Varoga, M. Tohidnezhad, and F. Paulsen The role of human beta-defensin-2 in bone J Anat 213 6 2008 749 757
12. D. Varoga, F. Paulsen, and S. Kohrs Expression and regulation of human beta-defensin-2 in osteoarthritic cartilage J Pathol 209 2 2006 166 173 (Pubitemid 43805411)
13. F. Paulsen, T. Pufe, and L. Conradi Antimicrobial peptides are expressed and produced in healthy and inflammed human synovial membranes J Pathol 198 3 2002 369 377 (Pubitemid 35277388)
14. F. Paulsen, T. Pufe, W. Petersen, and B. Tillmann Expression of natural peptide antibiotics in human articular cartilage and synovial membrane Clin Diagn Lab Immunol 8 5 2001 1021 1023 (Pubitemid 32868326)
15. D. Varoga, C.J. Wruck, and M. Tohidnezhad Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3 Histochem Cell Biol 131 2 2009 207 218
16. D. Varoga, T. Pufe, and R. Mentlein Expression and regulation of antimicrobial peptides in articular joints Ann Anat 187 5-6 2005 499 508 (Pubitemid 41715508)
17. D. Varoga, E. Klostermeier, and F. Paulsen The antimicrobial peptide HBD-2 and the toll-like receptors-2 and -4 are induced in synovial membranes in case of septic arthritis Virchows Arch May 2009
18. P.K. Singh, H.P. Jia, and K. Wiles Production of beta-defensins by human airway epithelia Proc Natl Acad Sci USA 95 December (25) 1998 14961 14966 (Pubitemid 29003739)
19. N.H. Salzman, D. Ghosh, and K.M. Huttner Protection against enteric Salmonellosis in transgenic mice expressing a human intestinal defensin Nature 422 April (6931) 2003 522 526 (Pubitemid 36433647)
20. C.L. Bevins, and F.T. Liu Rosacea: skin innate immunity gone awry? Nat Med 13 8 2007 904 906 (Pubitemid 47222032)
21. K. Yamasaki, A. Di Nardo, and A. Bardan Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea Nat Med 13 8 2007 975 980 (Pubitemid 47222043)
22. E.A. Nordahl, V. Rydengard, and P. Nyberg Activation of the complement system generates antibacterial peptides Proc Natl Acad Sci USA 101 November (48) 2004 16879 16884 (Pubitemid 39601332)
23. R.D. Soltis, D. Hasz, M.J. Morris, and I.D. Wilson The effect of heat inactivation of serum on aggregation of immunoglobulins Immunology 36 1 1979 37 45 (Pubitemid 9229575)
24. B. Schluter, B. Konig, and U. Bergmann Interleukin 6 - a potential mediator of lethal sepsis after major thermal trauma: evidence for increased IL-6 production by peripheral blood mononuclear cells J Trauma 31 12 1991 1663 1670
25. C. Albanesi, H.R. Fairchild, and S. Madonna IL-4 and IL-13 negatively regulate tnf-alpha- and ifn-gamma-induced beta-defensin expression through STAT-6 suppressor of cytokine signaling (SOCS)-1, and SOCS-3 J Immunol 179 July (2) 2007 984 992
26. B. Du, Y. Long, and H. Liu Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae bloodstream infection: risk factors and clinical outcome Intensive Care Med 28 12 2002 1718 1723 (Pubitemid 35435472)
27. P.Y. Ong, T. Ohtake, and C. Brandt Endogenous antimicrobial peptides and skin infections in atopic dermatitis N Engl J Med 347 October (15) 2002 1151 1160
28. M. Adib-Conquy, and J.M. Cavaillon Stress molecules in sepsis and systemic inflammatory response syndrome FEBS Lett 581 July (19) 2007 3723 3733 (Pubitemid 47080996)
29. G. Diamond, V. Kaiser, and J. Rhodes Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells Infect Immun 68 1 2000 113 119 (Pubitemid 30016685)
30. R. Bals, X. Wang, and Z. Wu Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung J Clin Invest 102 September (5) 1998 874 880 (Pubitemid 28419232)
31. A. Fahlgren, S. Hammarstrom, A. Danielsson, and M.L. Hammarstrom Beta-defensin-3 and -4 in intestinal epithelial cells display increased mrna expression in ulcerative colitis Clin Exp Immunol 137 2 2004 379 385 (Pubitemid 39013085)
32. N. Kanda, T. Ishikawa, and M. Kamata Increased serum leucine, leucine-37 levels in psoriasis: positive and negative feedback loops of leucine, leucine-37 and pro- or anti-inflammatory cytokines Hum Immunol 71 12 2010 1161 1171
33. W.G. Rice, T. Ganz, and J.M. Kinkade Jr. Defensin-rich dense granules of human neutrophils Blood 70 3 1987 757 765 (Pubitemid 18027409)