Intrathecal infusions of anisomycin impact the learning deficit but not the learning effect observed in spinal rats that have received instrumental training

Behavioural Brain Research

Volumn 173, Issue 2, 2006, Pages 299-309

  Baumbauer, Kyle M ^a   Young, Erin E ^a   Hoy Jr , Kevin C ^a   France, Jill L ^b   Joynes, Robin L ^b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b KENT STATE UNIVERSITY   (United States)

Author keywords

Anisomycin; Instrumental learning; Protein synthesis; Spinal cord; Spinal learning

Indexed keywords

ANISOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; INSTRUMENTAL CONDITIONING; LEARNING DISORDER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; STATE DEPENDENT LEARNING; TRAINING; TREATMENT OUTCOME;

ANIMALS; ANISOMYCIN; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; HINDLIMB; INJECTIONS, SPINAL; MALE; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; SPINAL CORD INJURIES; TIME FACTORS;

EID: 33747882056     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2006.06.041     Document Type: Article

References (35)

1. Baumbauer K.M., Young E.E., Hoy Jr. K.C., and Joynes R.L. Administration of an inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII) reverses the noncontingent shock learning deficit observed in spinal rats. Behav Neurosci 120 (2006)
2. Beggs A.L., Steinmetz J.E., and Patterson M.M. Classical conditioning of a flexor nerve response in spinal cats: effects of tibial nerve CS and a differential conditioning paradigm. Behav Neurosci 99 (1985) 496-508
3. Bolding K.A., Hook M.A., Ferguson A.R., and Grau J.W. The general protein kinase C inhibitor, bisindolylmaleimide-I, dose-dependently prevents a shock-induced behavioral deficit in spinalized rats. Abstract viewer/itinerary planner. (2003), Society for Neuroscience, Washington, DC CD-ROM
4. Bourtchouladze R., Abel T., Berman N., Gordon R., Lapidus K., and Kandel E.R. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learn Mem 5 (1998) 365-374
5. Buerger A.A., and Chopin S.F. Instrumental avoidance conditioning in spinal vertebrates. Adv Psychobiol 3 (1976) 437-461
6. Buerger A.A., and Dawson A.M. Spinal kittens: long-term increases in electromyograms due to a conditioning routine. Physiol Behav 14 (1968) 297-304
7. Crown E.D., Ferguson A.R., Joynes R.L., and Grau J.W. Instrumental learning within the spinal cord. IV. Induction and retention of the behavioral deficit observed after noncontingent shock. Behav Neurosci 116 (2002) 1032-1051
8. Davis S., Butcher S.P., and Morris R.G. The NMDA receptor antagonist d-2-amino-5-phosphonopentanoate (d-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci 12 (1992) 21-34
9. Davis H.P., and Squire L.R. Protein synthesis and memory: a review. Psychol Bull 96 (1984) 518-559
10. Durkovic R.G. Classical conditioning, sensitization, and habituation in the spinal cat. Physiol Behav 14 (1975) 297-304
11. Ferguson A.R., Crown E.D., Patton B.C., and Grau J.W. Intrathecal administration of the NMDA antagonist MK-801 prevents the behavioral deficit observed after noncontingent shock in spinalized rats. Program no. 166.7 abstract viewer/itinerary planner (2002), Society for Neuroscience, Washington, DC CD-ROM
12. Flood J.F., Rosenzweig M.R., Bennet E.L., and Orme A.E. The influence and duration of protein synthesis inhibition on memory. Physiol Behav 10 (1973) 555-562
13. Fung J., and Barbeau H. Effect of conditioning cutaneomuscular stimulation on the soleus H-reflex in normal and spastic paretic subjects during walking and standing. J Neurophysiol 72 (1994) 2090-2104
14. Gomez-Pinilla F., Ying Z., Ferguson A., Crown E., Edgerton V.R., and Grau A. BDNF supports spinal cord learning. Program no. 836.20 abstract viewer/itinerary planner (2004), Society for Neuroscience, Washington, DC CD-ROM
15. Grau J.W., Barstow D.G., and Joynes R.L. Instrumental learning within the spinal cord. I. Behavioral properties. Behav Neurosci 112 (1998) 1366-1386
16. Hou W.-Y., Shyu B.-C., Chen T.-M., Shieh J.-Y., and Sun W.-Z. Protein synthesis inhibitor cycloheximide dose-dependently decreases formalin-induced c-Fos protein and behavioral hyperalgesia in rats. Neurosci Lett 227 (1997) 99-102
17. Hu N.-W., Zhang H.-M., Hu X.-D., Li M.-T., Zhang T., Zhou L.-J., et al. Protein synthesis inhibition blocks the late-phase LTP of C-fibre evoked field potentials in rat spinal dorsal horn. J Neurophysiol 89 (2003) 2354-2359
18. Huie J.R., Gomez-Pinilla F., Ying Z., Edgerton V.R., and Grau J. BDNF enables learning in the rat spinal cord. Program no. 175.16 abstract viewer/itinerary planner (2005), Society for Neuroscience, Washington, DC CD-ROM
19. Huie J.R., Hoy K.C., Miranda R.C., and Grau J.W. BDNF facilitates learning in the rat spinal cord. Abstract viewer/itinerary planner (2006), Society for Neuroscience, Washington, DC
20. Joynes R.L., and Grau J.W. Mechanisms of Pavlovian conditioning: role of protection from habituation in spinal conditioning. Behav Neurosci 110 (1996) 1375-1387
21. Joynes R.L., and Grau J.W. Instrumental learning within the spinal cord. III. Prior exposure to noncontingent shock induces a behavioral deficit that is blocked by an opioid antagonist. Neuro Learn Mem 82 (2004) 35-51
22. Joynes R.L., Janjua K.R., and Grau J.W. Instrumental learning within the spinal cord. VI. The NMDA receptor antagonist, AP5, disrupts the acquisition and maintenance of an acquired flexion response. Behav Brain Res 154 (2004) 431-438
23. Kim J.J., DeCola J.P., Landeira-Fernandez J., and Fanselow M.S. N-Methyl-d-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning. Behav Neurosci 105 (1991) 126-133
24. Liu X.G., and Sandkühler J. Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-d-aspartic acid receptor blockage. Neurosci Lett 191 (1995) 43-46
25. Meiri N., and Rosenblum K. Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task. Brain Res 789 (1998) 48-55
26. Patton B.C., Hook M.A., Ferguson A.R., Crown E.D., and Grau J.W. The behavioral deficit observed following noncontingent shock in spinalized rats is prevented by the protein synthesis inhibitor cycloheximide. Behav Neurosci 118 (2004) 653-658
27. Rosenblum K., Meiri N., and Dudai Y. Taste memory: the role of protein synthesis in gustatory cortex. Behav Neurol Biol 59 (1993) 49-56
28. Schafe G.E., Nadel N.V., Sullivan G.M., Harris A., and LeDoux J.E. Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase. Learn Mem 6 (1999) 97-110
29. Segal R.L., and Wolf S.L. Operant conditioning of spinal stretch reflexes in patients with spinal cord injuries. Exp Neurol 130 (1994) 202-213
30. Wolpaw J.R., and Carp J.S. Memory traces in spinal cord. Trends Neurosci 13 (1990) 137-142
31. Wolpaw J.R., Lee C., and Carp J.S. Operant conditioned plasticity in spinal cord. Ann NY Acad Sci 627 (1991) 338-348
32. Xiong W., Kojic L.Z., Zhang L., Prassad S.S., Douglas R., Wang Y., et al. Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex. Brain Res 1085 (2006) 68-76
33. Yaksh T.H., and Rudy T.A. Chronic catheterization of the spinal cord subarachnoid space. Physiol Behav 17 (1976) 1031-1036
34. Ying S.-W., Futter M., Rosenblum K., Webber M.J., Hunt S.P., Bliss T.V.P., et al. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement of ERK activation coupled to CREB and upregulation of ARC synthesis. J Neurosci 22 (2002) 1532-1540
35. Yashpal K., Fisher K., Chabot J.G., and Coderre T.J. Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats. Pain 94 (2001) 17-29