Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro

Acta Pharmacologica Sinica

Volumn 33, Issue 7, 2012, Pages 935-940

  Li, Jun Yang ^a   Huang, Jia Yuan ^b   Li, Meng ^a   Zhang, Han ^a   Xing, Biao ^a   Chen, Gong ^a   Wei, Dong ^a   Gu, Pei Yuan ^a   Hu, Wei Xing ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

anisomycin; apoptosis; glioma; JNK; p38 MAPK; protein phosphatase 2A

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CHOLECYSTOKININ OCTAPEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PROTEIN EXPRESSION; TUMOR CELL LINE; WESTERN BLOTTING;

ANISOMYCIN; ANTI-BACTERIAL AGENTS; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; DOWN-REGULATION; ENZYME ACTIVATION; GLIOBLASTOMA; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN PHOSPHATASE 2; PROTEIN SUBUNITS; PROTEIN SYNTHESIS INHIBITORS;

EID: 84863677229     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.46     Document Type: Article

References (25)

1. Gold PE. Protein synthesis inhibition and memory: formation vs amnesia. Neurobiol Learn Mem 2008; 89: 201-11.
2. Yang H, Choi HJ, Park SH, Kim JS, Moon Y. Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells. Biochem Pharmacol 2009; 78: 1205-13.
3. Lunghi P, Tabilio A, Pinelli S, Valmadre G, Ridolo E, Albertini R, et al. Expression and activation of SHC/MAP kinase pathway in primary acute myeloid leukemia blasts. Hematol J 2001; 2: 70-80.
4. Caricchio R, D'Adamio L, Cohen PL. Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line. Cell Death Differ 2002; 9: 574-80.
5. Clerk A, Sugden PH. Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes. Biochem J 1997; 325: 801-10.
6. Mawji IA, Simpson CD, Gronda M, Williams MA, Hurren R, Henderson CJ, et al. A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Res 2007; 67: 8307-15.
7. Piekarski DJ, Seto T, Zucker I. The protein synthesis inhibitor anisomycin reduces sex behavior during a critical period after testosterone treatment in male Syrian hamsters. Physiol Behav 2011; 105: 215-9.
8. Sadowski RN, Canal CE, Gold PE. Lidocaine attenuates anisomycininduced amnesia and release of norepinephrine in the amygdala. Neurobiol Learn Mem 2011; 96: 136-42.
9. Malysheva MV, Grigoryev AA, Bulycheva TI, Zatsepina OV. Enhanced sensitivity of nucleoli in human proliferating cells to inhibition of protein synthesis with anisomycin. Bull Exp Biol Med 2010; 150: 258-62.
10. Croons V, Martinet W, Herman AG, Timmermans JP, De Meyer GR. The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase. J Pharmacol Exp Ther 2009; 329: 856-64.
11. Desgranges B, Levy F, Ferreira G. Anisomycin infusion in amygdala impairs consolidation of odor aversion memory. Brain Res 2008; 1236: 166-75.
12. Wang Q, Zhang JY, Liu SJ, Li HL. Overactivated mitogen-activated protein kinase by anisomycin induces tau hyperphosphorylation. Sheng Li Xue Bao 2008; 60: 485-91.
13. Qiao S, Murakami K, Zhao Q, Wang B, Seo H, Yamashita H, et al. Mimosine-induced apoptosis in C6 glioma cells requires the release of mitochondria-derived reactive oxygen species and p38, JNK activation. Neurochem Res 2012; 37: 417-27.
14. Junttila MR, Li SP, Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 2008; 22: 954-65.
15. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270: 1326-31.
16. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994; 124: 619-26.
17. Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol 2001; 13: 555-62.
18. Mawji IA, Simpson CD, Hurren R, Gronda M, Williams MA, Filmus J, et al. Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation. J Natl Cancer Inst 2007; 99: 811-22.
19. Frisch SM. Evidence for a function of death-receptor-related, deathdomain-containing proteins in anoikis. Curr Biol 1999; 9: 1047-9.
20. Rosen K, Shi W, Calabretta B, Filmus J. Cell detachment triggers p38 mitogen-activated protein kinase-dependent overexpression of Fas ligand. A novel mechanism of Anoikis of intestinal epithelial cells. J Biol Chem 2002; 277: 46123-30.
21. Ashley DM, Riffkin CD, Muscat AM, Knight MJ, Kaye AH, Novak U, et al. Caspase 8 is absent or low in many ex vivo gliomas. Cancer 2005; 104: 1487-96.
22. G otz J, Probst A, Ehler E, Hemmings B, Kues W. Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A 1998; 95: 12370-5.
23. He X, Anderson JC, del Pozo O, Gu YQ, Tang X, Martin GB. Silencing of subfamily I of protein phosphatase 2A catalytic subunits results in activation of plant defense responses and localized cell death. Plant J 2004; 38: 563-77.
24. Li X, Scuderi A, Letsou A, Virshup DM. B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Mol Cell Biol 2002; 22: 3674-84.
25. Wong LL, Zhang D, Chang CF, Koay ES. Silencing of the PP2A catalytic subunit causes HER-2/neu positive breast cancer cells to undergo apoptosis. Exp Cell Res 2010; 316: 3387-96.