Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in Osteomyelitis

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Widaa, Amro ^a   Claro, Tania ^a   Foster, Timothy J ^b   O'Brien, Fergal J ^a,b   Kerrigan, Steven W ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; STAPHYLOCOCCUS PROTEIN A;

ARTICLE; BINDING AFFINITY; BONE DESTRUCTION; CELL DIVISION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOMYELITIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION;

CELL MOVEMENT; CELL PROLIFERATION; HUMANS; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; OSTEOLYSIS; OSTEOMYELITIS; RANK LIGAND; STAPHYLOCOCCAL PROTEIN A; STAPHYLOCOCCUS AUREUS; TIME FACTORS;

STAPHYLOCOCCUS AUREUS;

EID: 84863819824     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040586     Document Type: Article

References (46)

1. Eriksen EF, (2010) Cellular mechanisms of bone remodeling. Rev Endocr Metab Disord 11: 219-227.
2. Whyte MP, (1994) Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization. Endocr Rev 15: 439-461.
3. Brodsky B, Persikov AV, (2005) Molecular structure of the collagen triple helix. Adv Protein Chem 70: 301-339.
4. Roach HI, (1994) Why does bone matrix contain non-collagenous proteins? The possible roles of osteocalcin, osteonectin, osteopontin and bone sialoprotein in bone mineralisation and resorption. Cell Biol Int 18: 617-628.
5. Roodman GD, (1996) Advances in bone biology: the osteoclast. Endocr Rev 17: 308-332.
6. Boyle WJ, Simonet WS, Lacey DL, (2003) Osteoclast differentiation and activation. Nature 423: 337-342.
7. Boyce BF, Xing L, (2008) Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 473: 139-146.
8. Goldenberg DL, (1998) Septic arthritis. Lancet 351: 197-202.
9. Lew DP, Waldvogel FA, (2004) Osteomyelitis. Lancet 364: 369-379.
10. Berendt T, Byren I, (2004) Bone and joint infection. Clin Med 4: 510-518.
11. Wright JA, Nair SP, (2010) Interaction of staphylococci with bone. Int J Med Microbiol 300: 193-204.
12. Lazzarini L, Mader JT, Calhoun JH, (2004) Osteomyelitis in long bones. J Bone Joint Surg Am 86-A: 2305-2318.
13. Rao N, Ziran BH, Lipsky BA, (2011) Treating osteomyelitis: antibiotics and surgery. Plast Reconstr Surg 127: 177S-187S.
14. Foster TJ, (2009) Colonization and infection of the human host by staphylococci: adhesion, survival and immune evasion. Vet Dermatol 20: 456-470.
15. Patti JM, Allen BL, McGavin MJ, Hook M, (1994) MSCRAMM-mediated adherence of microorganisms to host tissues. Annu Rev Microbiol 48: 585-617.
16. Hudson MC, Ramp WK, Frankenburg KP, (1999) Staphylococcus aureus adhesion to bone matrix and bone-associated biomaterials. FEMS Microbiol Lett 173: 279-284.
17. Dziewanowska K, Carson AR, Patti JM, Deobald CF, Bayles KW, et al. (2000) Staphylococcal fibronectin binding protein interacts with heat shock protein 60 and integrins: role in internalization by epithelial cells. Infect Immun 68: 6321-6328.
18. Ahmed S, Meghji S, Williams RJ, Henderson B, Brock JH, et al. (2001) Staphylococcus aureus fibronectin binding proteins are essential for internalization by osteoblasts but do not account for differences in intracellular levels of bacteria. Infect Immun 69: 2872-2877.
19. Claro T, Widaa A, O'Seaghdha M, Miajlovic H, Foster TJ, et al. (2011) Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis. PLoS One 6: e18748.
20. Cedergren L, Andersson R, Jansson B, Uhlen M, Nilsson B, (1993) Mutational analysis of the interaction between staphylococcal protein A and human IgG1. Protein Eng 6: 441-448.
21. Graille M, Stura EA, Corper AL, Sutton BJ, Taussig MJ, et al. (2000) Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity. Proc Natl Acad Sci U S A 97: 5399-5404.
22. O'Seaghdha M, van Schooten CJ, Kerrigan SW, Emsley J, Silverman GJ, et al. (2006) Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions. FEBS J 273: 4831-4841.
23. Gomez MI, Lee A, Reddy B, Muir A, Soong G, et al. (2004) Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat Med 10: 842-848.
24. Gomez MI, O'Seaghdha M, Magargee M, Foster TJ, Prince AS, (2006) Staphylococcus aureus protein A activates TNFR1 signaling through conserved IgG binding domains. J Biol Chem 281: 20190-20196.
25. Gomez MI, Seaghdha MO, Prince AS, (2007) Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling. EMBO J 26: 701-709.
26. Uhlen M, Guss B, Nilsson B, Gotz F, Lindberg M, (1984) Expression of the gene encoding protein A in Staphylococcus aureus and coagulase-negative staphylococci. J Bacteriol 159: 713-719.
27. Duffy GP, Ahsan T, O'Brien T, Barry F, Nerem RM, (2009) Bone marrow-derived mesenchymal stem cells promote angiogenic processes in a time- and dose-dependent manner in vitro. Tissue Eng Part A 15: 2459-2470.
28. Murshed M, Harmey D, Millan JL, McKee MD, Karsenty G, (2005) Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 19: 1093-1104.
29. Evans CA, Jellis J, Hughes SP, Remick DG, Friedland JS, (1998) Tumor necrosis factor-alpha, interleukin-6, and interleukin-8 secretion and the acute-phase response in patients with bacterial and tuberculous osteomyelitis. J Infect Dis 177: 1582-1587.
30. Klosterhalfen B, Peters KM, Tons C, Hauptmann S, Klein CL, et al. (1996) Local and systemic inflammatory mediator release in patients with acute and chronic posttraumatic osteomyelitis. J Trauma 40: 372-378.
31. Gilbert LC, Rubin J, Nanes MS, (2005) The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis. Am J Physiol Endocrinol Metab 288: E1011-1018.
32. Bu R, Borysenko CW, Li Y, Cao L, Sabokbar A, et al. (2003) Expression and function of TNF-family proteins and receptors in human osteoblasts. Bone 33: 760-770.
33. Gilbert LC, Rubin J, Nanes MS, (2005) The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis. American Journal of Physiology- Endocrinology And Metabolism 288: E1011-E1018.
34. Rosenquist JB, Ohlin A, Lerner UH, (1996) Cytokine-induced inhibition of bone matrix proteins is not mediated by prostaglandins. Inflamm Res 45: 457-463.
35. Taichman RS, Hauschka PV, (1992) Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. Inflammation 16: 587-601.
36. Li NH, Ouchi Y, Okamoto Y, Masuyama A, Kaneki M, et al. (1991) Effect of parathyroid hormone on release of interleukin 1 and interleukin 6 from cultured mouse osteoblastic cells. Biochem Biophys Res Commun 179: 236-242.
37. Pivirotto LA, Cissel DS, Keeting PE, (1995) Sex hormones mediate interleukin-1 beta production by human osteoblastic HOBIT cells. Mol Cell Endocrinol 111: 67-74.
38. Yoshii T, Magara S, Miyai D, Nishimura H, Kuroki E, et al. (2002) Local levels of interleukin-1beta,-4,-6 and tumor necrosis factor alpha in an experimental model of murine osteomyelitis due to staphylococcus aureus. Cytokine 19: 59-65.
39. Garcia-Alvarez F, Navarro-Zorraquino M, Castro A, Grasa JM, Pastor C, et al. (2009) Effect of age on cytokine response in an experimental model of osteomyelitis. Biogerontology 10: 649-658.
40. Teitelbaum SL, Ross FP, (2003) Genetic regulation of osteoclast development and function. Nat Rev Genet 4: 638-649.
41. Redlich K, Hayer S, Maier A, Dunstan CR, Tohidast-Akrad M, et al. (2002) Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis Rheum 46: 785-792.
42. Redlich K, Hayer S, Ricci R, David JP, Tohidast-Akrad M, et al. (2002) Osteoclasts are essential for TNF-alpha-mediated joint destruction. J Clin Invest 110: 1419-1427.
43. Wesson CA, Deringer J, Liou LE, Bayles KW, Bohach GA, et al. (2000) Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3. Infect Immun 68: 2998-3001.
44. Menzies BE, Kourteva I, (1998) Internalization of Staphylococcus aureus by endothelial cells induces apoptosis. Infect Immun 66: 5994-5998.
45. Tucker KA, Reilly SS, Leslie CS, Hudson MC, (2000) Intracellular Staphylococcus aureus induces apoptosis in mouse osteoblasts. FEMS Microbiol Lett 186: 151-156.
46. Grundmeier M, Hussain M, Becker P, Heilmann C, Peters G, et al. (2004) Truncation of Fibronectin-Binding Proteins in staphylococcus aureus Strain Newman Leads to Deficient Adherence and Host Cell Invasion Due to Loss of teh Cell Wall Anchor Function. Infect Immun 72: 7155-7163.