Retinal pigment epithelial cell death by the alternative complement cascade: Role of membrane regulatory proteins, calcium, PKC, and oxidative stress

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 5, 2014, Pages 3012-3021

  Yang, Ping ^a   Baciu, Peter ^b   Parker Kerrigan, Brittany C ^b   Etheridge, Menna ^b   Sung, Eric ^b   Toimil, Brett A ^a   Berchuck, Jacob E ^a   Jaffe, Glenn J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b ALLERGAN INC   (United States)

Author keywords

AMD; Calcium; Complement; Oxidative stress; PKC; RPE

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; COMPLEMENT COMPONENT C1Q; LACTATE DEHYDROGENASE; POLYCLONAL ANTIBODY; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ADULT; ARTICLE; CALCIUM DEPLETION; CELL COUNT; CELL DEATH; CELL VIABILITY; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MIDDLE AGED; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; WESTERN BLOTTING;

AMD; CALCIUM; COMPLEMENT; OXIDATIVE STRESS; PKC; RPE;

ANTIBODIES; CALCIUM; CELL DEATH; CELL LINE; COMPLEMENT PATHWAY, ALTERNATIVE; COMPLEMENT SYSTEM PROTEINS; HUMANS; MACULAR DEGENERATION; MEMBRANE PROTEINS; OXIDATIVE STRESS; PROTEIN KINASE C; RETINAL PIGMENT EPITHELIUM;

EID: 84900034024     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-13554     Document Type: Article

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