All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 4, 2013, Pages 2669-2677

  Berchuck, Jacob E ^a   Yang, Ping ^b   Toimil, Brett A ^b   Ma, Zhe ^b   Baciu, Peter ^c   Jaffe, Glenn J ^b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY   (United States)

^c ALLERGAN INC   (United States)

Author keywords

Age related macular degeneration; All trans retinal; Alternative complement pathway; Oxidative damage; Retinal pigment epithelium

Indexed keywords

CD59 ANTIGEN; COMPLEMENT COMPONENT C1Q; COMPLEMENT FIXING ANTIBODY; LACTATE DEHYDROGENASE; MEMBRANE COFACTOR PROTEIN; REACTIVE OXYGEN METABOLITE; RESVERATROL; RETINAL;

ADULT; ARTICLE; CELL DEATH; CELL VIABILITY; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANGIOGENESIS INHIBITORS; CELL DEATH; CELLS, CULTURED; COMPLEMENT PATHWAY, ALTERNATIVE; FLOW CYTOMETRY; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; RETINAL PIGMENT EPITHELIUM; RIBONUCLEOTIDE REDUCTASES; STILBENES;

EID: 84876086514     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11020     Document Type: Article

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