Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r

Journal of Biological Chemistry

Volumn 285, Issue 16, 2010, Pages 11863-11869

  Major, Balázs ^a   Kardos, József ^a,b   Kékesi, Katalin Adrienna ^b   Lorincz, Zsolt ^a   Závodszky, Péter ^a   Gál, Péter ^a  

^a INSTITUTE OF ENZYMOLOGY   (Hungary)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOACTIVATION; CLASSICAL PATHWAY; COMPLEMENT SYSTEMS; CONFORMATIONAL FLEXIBILITY; FOLDED STRUCTURES; FREEFORMS; FUNCTIONAL MODEL; GLOBULAR PROTEINS; INTRINSICALLY UNSTRUCTURED PROTEINS; ISOTHERMAL TITRATION CALORIMETRY; MARGINAL STABILITY; NON-CATALYTIC; PHYSICAL NATURE; POLYPEPTIDE CHAIN; SERINE PROTEASE;

AMINO ACIDS; PHOSPHATASES; PROTEINS;

CALCIUM;

CALCIUM ION; COMPLEMENT COMPONENT C1R; ENZYME PRECURSOR; PROTEIN CCP1; PROTEIN CUB2; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM BINDING; CALCIUM SIGNALING; COMPLEMENT CLASSICAL PATHWAY; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE AMPLIFICATION; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE;

BASE SEQUENCE; CALCIUM; COMPLEMENT C1R; DNA PRIMERS; ENZYME ACTIVATION; HUMANS; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 77951216899     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.098541     Document Type: Article

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