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Volumn 114, Issue 6, 2014, Pages 464-471

Sensitization of hepatocellular carcinoma cells to Apo2L/TRAIL by a novel Akt/NF-κB signalling inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DULANERMIN; I KAPPA B; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; SURVIVIN; TRANSCRIPTION FACTOR RELA; CASPASE 3; CASPASE 8; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLE DERIVATIVE; METHANOL; OSU-A9 AGENT; RELA PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

EID: 84900025657     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12190     Document Type: Article
Times cited : (32)

References (37)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-76.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 31144437639 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: therapy and prevention
    • Blum HE. Hepatocellular carcinoma: therapy and prevention. World J Gastroenterol 2005;11:7391-400.
    • (2005) World J Gastroenterol , vol.11 , pp. 7391-7400
    • Blum, H.E.1
  • 3
    • 12344289067 scopus 로고    scopus 로고
    • Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma
    • Nakanishi K, Sakamoto M, Yamasaki S, Todo S, Hirohashi S. Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma. Cancer 2005;103:307-12.
    • (2005) Cancer , vol.103 , pp. 307-312
    • Nakanishi, K.1    Sakamoto, M.2    Yamasaki, S.3    Todo, S.4    Hirohashi, S.5
  • 4
    • 0037108089 scopus 로고    scopus 로고
    • Role of Rel/NF-kappaB transcription factors in apoptosis of human hepatocellular carcinoma cells
    • Chiao PJ, Na R, Niu J, Sclabas GM, Dong Q, Curley SA. Role of Rel/NF-kappaB transcription factors in apoptosis of human hepatocellular carcinoma cells. Cancer 2002;95:1696-705.
    • (2002) Cancer , vol.95 , pp. 1696-1705
    • Chiao, P.J.1    Na, R.2    Niu, J.3    Sclabas, G.M.4    Dong, Q.5    Curley, S.A.6
  • 5
    • 70350438403 scopus 로고    scopus 로고
    • Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma
    • Omar HA, Sargeant AM, Weng JR, Wang D, Kulp SK, Patel T et al. Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. Mol Pharmacol 2009;76:957-68.
    • (2009) Mol Pharmacol , vol.76 , pp. 957-968
    • Omar, H.A.1    Sargeant, A.M.2    Weng, J.R.3    Wang, D.4    Kulp, S.K.5    Patel, T.6
  • 6
    • 77957334057 scopus 로고    scopus 로고
    • A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro
    • Weng JR, Bai LY, Omar HA, Sargeant AM, Yeh CT, Chen YY et al. A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro. Oral Oncol 2010;46:748-54.
    • (2010) Oral Oncol , vol.46 , pp. 748-754
    • Weng, J.R.1    Bai, L.Y.2    Omar, H.A.3    Sargeant, A.M.4    Yeh, C.T.5    Chen, Y.Y.6
  • 7
    • 70349986398 scopus 로고    scopus 로고
    • OSU-A9, a potent indole-3-carbinol derivative, suppresses breast tumor growth by targeting the Akt-NF-kappaB pathway and stress response signaling
    • Weng JR, Tsai CH, Omar HA, Sargeant AM, Wang D, Kulp SK et al. OSU-A9, a potent indole-3-carbinol derivative, suppresses breast tumor growth by targeting the Akt-NF-kappaB pathway and stress response signaling. Carcinogenesis 2009;30:1702-9.
    • (2009) Carcinogenesis , vol.30 , pp. 1702-1709
    • Weng, J.R.1    Tsai, C.H.2    Omar, H.A.3    Sargeant, A.M.4    Wang, D.5    Kulp, S.K.6
  • 8
    • 84884722125 scopus 로고    scopus 로고
    • OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways
    • Omar HA, Arafa E-SA, Salama SA, Arab HH, Wu CH, Weng JR. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways. Toxicol Appl Pharmacol 2013;272:616-24.
    • (2013) Toxicol Appl Pharmacol , vol.272 , pp. 616-624
    • Omar, H.A.1    Arafa, E.-S.2    Salama, S.A.3    Arab, H.H.4    Wu, C.H.5    Weng, J.R.6
  • 9
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • Nakanishi C, Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 2005;5:297-309.
    • (2005) Nat Rev Cancer , vol.5 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 10
    • 34347272996 scopus 로고    scopus 로고
    • Clearing the TRAIL for cancer therapy
    • Hall MA, Cleveland JL. Clearing the TRAIL for cancer therapy. Cancer Cell 2007;12:4-6.
    • (2007) Cancer Cell , vol.12 , pp. 4-6
    • Hall, M.A.1    Cleveland, J.L.2
  • 12
    • 35348881412 scopus 로고    scopus 로고
    • TRAIL death receptors and cancer therapeutics
    • Huang Y, Sheikh MS. TRAIL death receptors and cancer therapeutics. Toxicol Appl Pharmacol 2007;224:284-9.
    • (2007) Toxicol Appl Pharmacol , vol.224 , pp. 284-289
    • Huang, Y.1    Sheikh, M.S.2
  • 13
    • 77956321948 scopus 로고    scopus 로고
    • Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells
    • Xu J, Zhou JY, Wei WZ, Wu GS. Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. PLoS One 2010;5:e10226-33.
    • (2010) PLoS One , vol.5
    • Xu, J.1    Zhou, J.Y.2    Wei, W.Z.3    Wu, G.S.4
  • 14
    • 66449131460 scopus 로고    scopus 로고
    • Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    • Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP et al. Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 2009;284:11121-33.
    • (2009) J Biol Chem , vol.284 , pp. 11121-11133
    • Chen, K.F.1    Yeh, P.Y.2    Hsu, C.3    Hsu, C.H.4    Lu, Y.S.5    Hsieh, H.P.6
  • 15
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    • Beg AA, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996;274:782-4.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 16
    • 0033177897 scopus 로고    scopus 로고
    • NF- kappa B and chemoresistance: potentiation of cancer drugs via inhibition of NF- kappa B
    • Cusack JC, Liu R, Baldwin AS. NF- kappa B and chemoresistance: potentiation of cancer drugs via inhibition of NF- kappa B. Drug Resist Updat 1999;2:271-3.
    • (1999) Drug Resist Updat , vol.2 , pp. 271-273
    • Cusack, J.C.1    Liu, R.2    Baldwin, A.S.3
  • 17
    • 0036895749 scopus 로고    scopus 로고
    • TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells
    • Kim YS, Schwabe RF, Qian T, Lemasters JJ, Brenner DA. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology 2002;36:1498-508.
    • (2002) Hepatology , vol.36 , pp. 1498-1508
    • Kim, Y.S.1    Schwabe, R.F.2    Qian, T.3    Lemasters, J.J.4    Brenner, D.A.5
  • 19
    • 0033839749 scopus 로고    scopus 로고
    • Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines
    • Yamanaka T, Shiraki K, Sugimoto K, Ito T, Fujikawa K, Ito M et al. Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines. Hepatology 2000;32:482-90.
    • (2000) Hepatology , vol.32 , pp. 482-490
    • Yamanaka, T.1    Shiraki, K.2    Sugimoto, K.3    Ito, T.4    Fujikawa, K.5    Ito, M.6
  • 20
    • 35648993596 scopus 로고    scopus 로고
    • Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization
    • Meng XW, Lee SH, Dai H, Loegering D, Yu C, Flatten K et al. Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization. J Biol Chem 2007;282:29831-46.
    • (2007) J Biol Chem , vol.282 , pp. 29831-29846
    • Meng, X.W.1    Lee, S.H.2    Dai, H.3    Loegering, D.4    Yu, C.5    Flatten, K.6
  • 21
    • 34347246278 scopus 로고    scopus 로고
    • Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death
    • Ricci MS, Kim SH, Ogi K, Plastaras JP, Ling J, Wang W et al. Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell 2007;12:66-80.
    • (2007) Cancer Cell , vol.12 , pp. 66-80
    • Ricci, M.S.1    Kim, S.H.2    Ogi, K.3    Plastaras, J.P.4    Ling, J.5    Wang, W.6
  • 22
    • 2442663096 scopus 로고    scopus 로고
    • Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells
    • Taniai M, Grambihler A, Higuchi H, Werneburg N, Bronk SF, Farrugia DJ et al. Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells. Cancer Res 2004;64:3517-24.
    • (2004) Cancer Res , vol.64 , pp. 3517-3524
    • Taniai, M.1    Grambihler, A.2    Higuchi, H.3    Werneburg, N.4    Bronk, S.F.5    Farrugia, D.J.6
  • 23
    • 34548050174 scopus 로고    scopus 로고
    • A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells
    • Weng JR, Tsai CH, Kulp SK, Wang D, Lin CH, Yang HC et al. A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells. Cancer Res 2007;67:7815-24.
    • (2007) Cancer Res , vol.67 , pp. 7815-7824
    • Weng, J.R.1    Tsai, C.H.2    Kulp, S.K.3    Wang, D.4    Lin, C.H.5    Yang, H.C.6
  • 24
    • 84880136915 scopus 로고    scopus 로고
    • Synthesis, anti-breast cancer activity, and molecular modeling of some benzothiazole and benzoxazole derivatives
    • Abdelgawad MA, Belal A, Omar HA, Hegazy L, Rateb ME. Synthesis, anti-breast cancer activity, and molecular modeling of some benzothiazole and benzoxazole derivatives. Arch Pharm 2013;346:534-41.
    • (2013) Arch Pharm , vol.346 , pp. 534-541
    • Abdelgawad, M.A.1    Belal, A.2    Omar, H.A.3    Hegazy, L.4    Rateb, M.E.5
  • 25
    • 33749029926 scopus 로고    scopus 로고
    • Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer
    • Kulp SK, Chen CS, Wang DS, Chen CY. Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer. Clin Cancer Res 2006;12:5199-206.
    • (2006) Clin Cancer Res , vol.12 , pp. 5199-5206
    • Kulp, S.K.1    Chen, C.S.2    Wang, D.S.3    Chen, C.Y.4
  • 28
    • 27744609173 scopus 로고    scopus 로고
    • Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5)
    • Jung EM, Lim JH, Lee TJ, Park JW, Choi KS, Kwon TK. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Carcinogenesis 2005;26:1905-13.
    • (2005) Carcinogenesis , vol.26 , pp. 1905-1913
    • Jung, E.M.1    Lim, J.H.2    Lee, T.J.3    Park, J.W.4    Choi, K.S.5    Kwon, T.K.6
  • 29
    • 32944475745 scopus 로고    scopus 로고
    • Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5
    • Kim H, Kim EH, Eom YW, Kim WH, Kwon TK, Lee SJ et al. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Cancer Res 2006;66:1740-50.
    • (2006) Cancer Res , vol.66 , pp. 1740-1750
    • Kim, H.1    Kim, E.H.2    Eom, Y.W.3    Kim, W.H.4    Kwon, T.K.5    Lee, S.J.6
  • 30
    • 0033821215 scopus 로고    scopus 로고
    • The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase
    • Lin Y, Devin A, Cook A, Keane MM, Kelliher M, Lipkowitz S et al. The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase. Mol Cell Biol 2000;20:6638-45.
    • (2000) Mol Cell Biol , vol.20 , pp. 6638-6645
    • Lin, Y.1    Devin, A.2    Cook, A.3    Keane, M.M.4    Kelliher, M.5    Lipkowitz, S.6
  • 31
    • 0141891256 scopus 로고    scopus 로고
    • Suppression of NF-kappa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL
    • Chawla-Sarkar M, Bauer JA, Lupica JA, Morrison BH, Tang Z, Oates RK et al. Suppression of NF-kappa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL. J Biol Chem 2003;278:39461-9.
    • (2003) J Biol Chem , vol.278 , pp. 39461-39469
    • Chawla-Sarkar, M.1    Bauer, J.A.2    Lupica, J.A.3    Morrison, B.H.4    Tang, Z.5    Oates, R.K.6
  • 32
    • 77951043153 scopus 로고    scopus 로고
    • The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis
    • Pellerito O, Calvaruso G, Portanova P, De Blasio A, Santulli A, Vento R et al. The synthetic cannabinoid WIN 55, 212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis. Mol Pharmacol 2010;77:854-63.
    • (2010) Mol Pharmacol , vol.77 , pp. 854-863
    • Pellerito, O.1    Calvaruso, G.2    Portanova, P.3    De Blasio, A.4    Santulli, A.5    Vento, R.6
  • 33
    • 63649143578 scopus 로고    scopus 로고
    • Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB
    • Wang C, Chen T, Zhang N, Yang M, Li B, Lu X et al. Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB. J Biol Chem 2009;284:3804-13.
    • (2009) J Biol Chem , vol.284 , pp. 3804-3813
    • Wang, C.1    Chen, T.2    Zhang, N.3    Yang, M.4    Li, B.5    Lu, X.6
  • 34
    • 4344607589 scopus 로고    scopus 로고
    • Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
    • Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC et al. Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ 2004;11(Suppl. 1):S86-96.
    • (2004) Cell Death Differ , vol.11 , Issue.SUPPL. 1
    • Ganten, T.M.1    Haas, T.L.2    Sykora, J.3    Stahl, H.4    Sprick, M.R.5    Fas, S.C.6
  • 35
    • 84984559474 scopus 로고    scopus 로고
    • Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
    • Chen KF, Tai WT, Liu TH, Huang HP, Lin YC, Shiau CW et al. Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3. Clin Cancer Res 2010;16:5189-99.
    • (2010) Clin Cancer Res , vol.16 , pp. 5189-5199
    • Chen, K.F.1    Tai, W.T.2    Liu, T.H.3    Huang, H.P.4    Lin, Y.C.5    Shiau, C.W.6
  • 36
    • 33748554165 scopus 로고    scopus 로고
    • Survivin downregulation by siRNA sensitizes human hepatoma cells to TRAIL-induced apoptosis
    • Nakao K, Hamasaki K, Ichikawa T, Arima K, Eguchi K, Ishii N. Survivin downregulation by siRNA sensitizes human hepatoma cells to TRAIL-induced apoptosis. Oncol Rep 2006;16:389-92.
    • (2006) Oncol Rep , vol.16 , pp. 389-392
    • Nakao, K.1    Hamasaki, K.2    Ichikawa, T.3    Arima, K.4    Eguchi, K.5    Ishii, N.6
  • 37
    • 0038018408 scopus 로고    scopus 로고
    • Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP
    • Jeon KI, Rih JK, Kim HJ, Lee YJ, Cho CH, Goldberg ID et al. Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP. FEBS Lett 2003;544:246-51.
    • (2003) FEBS Lett , vol.544 , pp. 246-251
    • Jeon, K.I.1    Rih, J.K.2    Kim, H.J.3    Lee, Y.J.4    Cho, C.H.5    Goldberg, I.D.6


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