Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses

Acta Neuropathologica

Volumn 127, Issue 5, 2014, Pages 713-729

  Schweingruber, Nils ^a   Fischer, Henrike J ^a   Fischer, Lisa ^a   Van Den Brandt, Jens ^a,d   Karabinskaya, Anna ^a   Labi, Verena ^b,e   Villunger, Andreas ^b   Kretzschmar, Benedikt ^a   Huppke, Peter ^a   Simons, Mikael ^a   Tuckermann, Jan P ^c   Flügel, Alexander ^a   Lühder, Fred ^a   Reichardt, Holger M ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY OF ULM   (Germany)

^d Medical University of Greifswald   (Germany)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Apoptosis; CXCR4; EAE; Glucocorticoids; MS patients; Multiple sclerosis

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; GLUCOCORTICOID; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; METHYLPREDNISOLONE; PLERIXAFOR; NEUROPROTECTIVE AGENT;

APOPTOSIS; ARTICLE; CELL MIGRATION; CELLULAR DISTRIBUTION; DIMERIZATION; DISEASE COURSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG PULSE THERAPY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ADULT; AGED; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL MOTION; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; METABOLISM; MIDDLE AGED; MULTIPLE SCLEROSIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPINAL CORD; TRANSGENIC MOUSE;

ADULT; AGED; ANIMALS; APOPTOSIS; CELL MOVEMENT; CHEMOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; MULTIPLE SCLEROSIS; NEUROPROTECTIVE AGENTS; SPINAL CORD; T-LYMPHOCYTES;

EID: 84899986621     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1248-4     Document Type: Article

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