Increased expression of MIP-3α/CCL20 in peripheral blood mononuclear cells from patients with ulcerative colitis and its down-regulation by sulfasalazine and glucocorticoid treatment

Inflammatory Bowel Diseases

Volumn 11, Issue 12, 2005, Pages 1070-1079

  Lee, Hyun Ju ^a   Choi, Suck Chei ^b   Lee, Moo Hyung ^a   Oh, Hyun Mee ^a   Choi, Eun Young ^a   Choi, Eun Ju ^a   Yun, Ki Jung ^b   Seo, Geom Seog ^b   Kim, Sang Wook ^c   Lee, Jeong Geun ^b   Han, Weon Cheol ^b   Park, Kie In ^d   Jun, Chang Duk ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Wonkwang University   (South Korea)

^c Jeonbuk National University Medical School and Hospital   (South Korea)

^d Chonbuk National University   (South Korea)

Author keywords

CCL20; CCR6; Inflammatory bowel diseases; Peripheral blood mononuclear cells

Indexed keywords

GLUCOCORTICOID; INTERLEUKIN 1; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESALAZINE; MESSENGER RNA; METRONIDAZOLE; QUINOLONE; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD SAMPLING; CELL LINE; CELL POPULATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ACTIVITY; DISEASE SEVERITY; DOWN REGULATION; ENTERITIS; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; INTESTINE EPITHELIUM CELL; KOREA; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; ULCERATIVE COLITIS; UPREGULATION;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMOKINES, CC; COLITIS, ULCERATIVE; DEXAMETHASONE; DOWN-REGULATION; FEMALE; GLUCOCORTICOIDS; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOCYTES, MONONUCLEAR; MACROPHAGE INFLAMMATORY PROTEINS; MALE; MESALAMINE; SULFASALAZINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 27944505074     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/01.MIB.0000187576.26043.ac     Document Type: Article

References (36)

1. Middel P, Reich K, Polzien F, et al. Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease. Gut. 2001;49:795-803.
2. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411:599-603.
3. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411:603-606.
4. Ogura Y, Lala S, Xin W, et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut. 2003;52:1591-1597.
5. Tokuhiro S, Yamada R, Chang X, et al. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet. 2003;35:341-348.
6. Hieshima K, Imai T, Opdenakker G, et al. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem. 1997;272:5846-5853.
7. Schutyser E, Struyf S, Van Damme J. The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev. 2003;14:409-426.
8. Kwon JH, Keates S, Bassani L, et al. Colonic epithelial cells are a major site of macrophage inflammatory protein 3α (MIP-3α) production in normal colon and inflammatory bowel disease. Gut. 2002;51:818-826.
9. Kaser A, Ludwiczek O, Holzmann S, et al. Increased expression of CCL20 in human inflammatory bowel disease. J Clin Immunol. 2004;24:74-85.
10. Truelove SC, Witts LJ. Cortisone in ulcerative colitis. final report on a therapeutic trial. Br Med J. 1955;4947:1041-1048.
11. Scapini P, Laudanna C, Pinardi C, et al. Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3α)/CCL20 and MIP-3β/CCL19. Eur J Immunol. 2001;31:1981-1988.
12. Choi EY, Kim EC, Oh HM, et al. Iron chelator triggers inflammatory signals in human intestinal epithelial cells: involvement of p38 and extracellular signal-regulated kinase signaling pathways. J Immunol. 2004;172:7069-7077.
13. Holland PM, Abramson RD, Watson R, et al. Detection of specific polymerase chain reaction product by utilizing the 5′-3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc Natl Acad Sci USA. 1991;88:7276-7280.
14. Crotty B, Rosenberg WM, Aronson JK, et al. Inhibition of binding of interferon-gamma to its receptor by salicylates used in inflammatory bowel disease. Gut. 1992;33:1353-1357.
15. Saitoh O, Matsuse R, Sugi K, et al. Cyclosporine A inhibits interleukin-8 production in a human colon epithelial cell line (HT-29). J Gastroenterol. 1997;32:605-610.
16. Sierro F, Dubois B, Coste A, et al. Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc Natl Acad Sci USA. 2001;98:13722-13727.
17. Doering J, Begue B, Lentze MJ, et al. Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease. Gut. 2004;53:1632-1638.
18. Huang GT, Eckmann L, Savidge TC, et al. Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion. J Clin Invest. 1996;98:572-583.
19. Rossi DL, Vicari AP, Franz-Bacon K, et al. Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3α and MIP-3β. J Immunol. 1997;158:1033-1036.
20. Nakayama T, Fujisawa R, Yamada H, et al. Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3α/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int Immunol. 2001;13:95-103.
21. Holub MC, Mako E, Devay T, et al. Increased interleukin-6 levels, interleukin-6 receptor and gp130 expression in peripheral lymphocytes of patients with inflammatory bowel disease. Scand J Gastroenterol Suppl. 1998;228:47-50.
22. Murakami H, Akbar SM, Matsui H, et al. Macrophage migration inhibitory factor in the sera and at the colonic mucosa in patients with ulcerative colitis: clinical implications and pathogenic significance. Eur J Clin Invest. 2001;31:337-343.
23. Izadpanah A, Dwinell MB, Eckmann L, et al. Regulated MIP-3α/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. Am J Physiol Gastrointest Liver Physiol. 2001;280:G710-G719.
24. Brannigan AE, O'Connell PR, Hurley H, et al. Neutrophil apoptosis is delayed in patients with inflammatory bowel disease. Shock. 2000;13:361-366.
25. Ina K, Kusugami K, Hosokawa T, et al. Increased mucosal production of granulocyte colony-stimulating factor is related to a delay in neutrophil apoptosis in Inflammatory Bowel disease. J Gastroenterol Hepatol. 1999;14:46-53.
26. Jaleel MA, Tsai AC, Sarkar S, et al. Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival. Mol Hum Reprod. 2004;10:901-909.
27. Banas B, Wornle M, Berger T, et al. Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J Immunol. 2002;168:4301-4307.
28. Ahmad T, Satsangi J, McGovern D, et al. Review article: the genetics of inflammatory bowel disease. Aliment Pharmacol Ther. 2001;15:731-748.
29. Toyoda H, Wang SJ, Yang HY, et al. Distinct associations of HLA class II genes with inflammatory bowel disease. Gastroenterology. 1993;104:741-748.
30. Klein W, Tromm A, Griga T, et al. A polymorphism in the IL11 gene is associated with ulcerative colitis. Genes Immun. 2002;3:494-496.
31. Kojima Y, Kinouchi Y, Takahashi S, et al. Inflammatory bowel disease is associated with a novel promoter polymorphism of natural resistance-associated macrophage protein 1 (NRAMP1) gene. Tissue Antigens. 2001;58:379-384.
32. Parkes M, Satsangi J, Jewell D. Contribution of the IL-2 and IL-10 genes to inflammatory bowel disease (IBD) susceptibility. Clin Exp Immunol. 1998;113:28-32.
33. Frenzel H, Hampe J, Huse K, et al. Mutation detection and physical mapping of the CD11 gene cluster in association with inflammatory bowel disease. Immunogenetics. 2002;53:835-842.
34. Klein W, Tromm A, Griga T, et al. Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases. Genes Immun. 2001;2:287-289.
35. Low JH, Williams FA, Yang X, et al. Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. Inflamm Bowel Dis. 2004;10:173-181.
36. van Heel DA, Fisher SA, Kirby A, et al. Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet. 2004;13:763-770.