메뉴 건너뛰기




Volumn 129, Issue 10, 2006, Pages 2635-2647

Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis

Author keywords

Cell migration; CXCR 3; Experimental autoimmune encephalomyelitis; Immunotherapy; Regulatory T cells

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CYTOKINE; ENHANCED GREEN FLUORESCENT PROTEIN; GAMMA INTERFERON; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY JJ316; UNCLASSIFIED DRUG;

EID: 33749464498     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awl213     Document Type: Article
Times cited : (70)

References (50)
  • 2
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigenspecific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • Ben-Nun A, Wekerle H, Cohen IR. The rapid isolation of clonable antigenspecific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 1981; 11: 195-9.
    • (1981) Eur J Immunol , vol.11 , pp. 195-199
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 3
    • 23744517125 scopus 로고    scopus 로고
    • Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
    • Beyersdorf N, Gaupp S, Balbach K, Schmidt J, Toyka KV, Lin CH, et al. Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J Exp Med 2005; 202: 445-55.
    • (2005) J Exp Med , vol.202 , pp. 445-455
    • Beyersdorf, N.1    Gaupp, S.2    Balbach, K.3    Schmidt, J.4    Toyka, K.V.5    Lin, C.H.6
  • 4
    • 27144495833 scopus 로고    scopus 로고
    • How do CD4+CD25+ regulatory T cells control autoimmunity?
    • Bluestone JA, Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol 2005; 17: 638-42.
    • (2005) Curr Opin Immunol , vol.17 , pp. 638-642
    • Bluestone, J.A.1    Tang, Q.2
  • 6
    • 20444414184 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis
    • Denning TL, Kim G, Kronenberg M. Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis. J Immunol 2005; 174: 7487-91.
    • (2005) J Immunol , vol.174 , pp. 7487-7491
    • Denning, T.L.1    Kim, G.2    Kronenberg, M.3
  • 7
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms
    • Engelhardt B, Ransohoff RM. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol 2005; 26: 485-95.
    • (2005) Trends Immunol , vol.26 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 9
    • 0344780200 scopus 로고    scopus 로고
    • Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses
    • Flügel A, Willem M, Berkowicz T, Wekerle H. Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nat Med 1999; 5: 843-7.
    • (1999) Nat Med , vol.5 , pp. 843-847
    • Flügel, A.1    Willem, M.2    Berkowicz, T.3    Wekerle, H.4
  • 10
    • 0035005143 scopus 로고    scopus 로고
    • Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
    • Flügel A, Berkowicz T, Ritter T, Labeur M, Jenne DE, Li Z, et al. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity 2001; 14: 547-60.
    • (2001) Immunity , vol.14 , pp. 547-560
    • Flügel, A.1    Berkowicz, T.2    Ritter, T.3    Labeur, M.4    Jenne, D.E.5    Li, Z.6
  • 11
    • 0029036160 scopus 로고
    • T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease
    • Gold R, Giegerich G, Hartung HP, Toyka KV. T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable- region V beta 8.2-positive T cells are not essential for induction and course of disease. Proc Natl Acad Sci USA 1995; 92: 5850-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5850-5854
    • Gold, R.1    Giegerich, G.2    Hartung, H.P.3    Toyka, K.V.4
  • 12
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 Years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold R, Linington C, Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006; 129: 1953-71.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 13
    • 0036196305 scopus 로고    scopus 로고
    • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: Highly potent regulators of diabetes that require TRANCE-RANK signals
    • Green EA, Choi Y, Flavell RA. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 2002; 16: 183-91.
    • (2002) Immunity , vol.16 , pp. 183-191
    • Green, E.A.1    Choi, Y.2    Flavell, R.A.3
  • 14
    • 2942692037 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
    • Herman AE, Freeman GJ, Mathis D, Benoist C. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med 2004; 199: 1479-89.
    • (2004) J Exp Med , vol.199 , pp. 1479-1489
    • Herman, A.E.1    Freeman, G.J.2    Mathis, D.3    Benoist, C.4
  • 16
    • 2942674466 scopus 로고    scopus 로고
    • Foxp3: A critical regulator of the development and function of regulatory T cells
    • Hori S, Sakaguchi S. Foxp3: a critical regulator of the development and function of regulatory T cells. Microbes Infect 2004; 6: 745-51.
    • (2004) Microbes Infect , vol.6 , pp. 745-751
    • Hori, S.1    Sakaguchi, S.2
  • 17
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999; 162: 5317-26.
    • (1999) J Immunol , vol.162 , pp. 5317-5326
    • Itoh, M.1    Takahashi, T.2    Sakaguchi, N.3    Kuniyasu, Y.4    Shimizu, J.5    Otsuka, F.6
  • 18
    • 0029057866 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis in Lewis rats by antibodies against CD2
    • Jung S, Toyka K, Hartung HP. Suppression of experimental autoimmune encephalomyelitis in Lewis rats by antibodies against CD2. Eur J Immunol 1995; 25: 1391-8.
    • (1995) Eur J Immunol , vol.25 , pp. 1391-1398
    • Jung, S.1    Toyka, K.2    Hartung, H.P.3
  • 19
    • 15944425718 scopus 로고    scopus 로고
    • CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset
    • Kleinewietfeld M, Puentes F, Borsellino G, Battistini L, Rotzschke O, Falk K. CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset. Blood 2005; 105: 2877-86.
    • (2005) Blood , vol.105 , pp. 2877-2886
    • Kleinewietfeld, M.1    Puentes, F.2    Borsellino, G.3    Battistini, L.4    Rotzschke, O.5    Falk, K.6
  • 20
    • 0036838536 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • Kohm AP, Carpentier PA, Anger HA, Miller SD. Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 2002; 169: 4712-6.
    • (2002) J Immunol , vol.169 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 21
    • 0037352740 scopus 로고    scopus 로고
    • Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist
    • Lin CH, Hünig T. Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist. Eur J Immunol 2003; 33: 626-38.
    • (2003) Eur J Immunol , vol.33 , pp. 626-638
    • Lin, C.H.1    Hünig, T.2
  • 22
    • 15944428160 scopus 로고    scopus 로고
    • In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3
    • Lundsgaard D, Holm TL, Hornum L, Markholst H. In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3. Diabetes 2005; 54: 1040-7.
    • (2005) Diabetes , vol.54 , pp. 1040-1047
    • Lundsgaard, D.1    Holm, T.L.2    Hornum, L.3    Markholst, H.4
  • 23
    • 0034622276 scopus 로고    scopus 로고
    • Science, medicine and the future: Tolerance and autoimmunity
    • Mackay IR. Science, medicine and the future: tolerance and autoimmunity. Br Med J 2000; 321: 93-6.
    • (2000) Br Med J , vol.321 , pp. 93-96
    • Mackay, I.R.1
  • 25
    • 23844478869 scopus 로고    scopus 로고
    • Natural recovery and protection from autoimmune encephalomyelitis: Contribution of CD4+CD25+ regulatory cells within the central nervous system
    • McGeachy MJ, Stephens LA, Anderton SM. Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system. J Immunol 2005; 175: 3025-32.
    • (2005) J Immunol , vol.175 , pp. 3025-3032
    • McGeachy, M.J.1    Stephens, L.A.2    Anderton, S.M.3
  • 26
    • 0142043832 scopus 로고    scopus 로고
    • Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression
    • Moldovan IR, Rudick RA, Cotleur AC, Born SE, Lee JC, Karafa MT, et al. Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression. J Neuroimmunol 2003; 141: 132-40.
    • (2003) J Neuroimmunol , vol.141 , pp. 132-140
    • Moldovan, I.R.1    Rudick, R.A.2    Cotleur, A.C.3    Born, S.E.4    Lee, J.C.5    Karafa, M.T.6
  • 28
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
    • Mottet C, Uhlig HH, Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003; 170: 3939-43.
    • (2003) J Immunol , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 29
    • 26944480376 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control the progression from periinsulitis to destructive insulitis in murine autoimmune diabetes
    • Ott PA, Anderson MR, Tary-Lehmann M, Lehmann PV. CD4+CD25+ regulatory T cells control the progression from periinsulitis to destructive insulitis in murine autoimmune diabetes. Cell Immunol 2005; 235: 1-11.
    • (2005) Cell Immunol , vol.235 , pp. 1-11
    • Ott, P.A.1    Anderson, M.R.2    Tary-Lehmann, M.3    Lehmann, P.V.4
  • 30
    • 0035128996 scopus 로고    scopus 로고
    • Genetic models for CNS inflammation
    • Owens T, Wekerle H, Antel J. Genetic models for CNS inflammation. Nat Med 2001; 7: 161-6.
    • (2001) Nat Med , vol.7 , pp. 161-166
    • Owens, T.1    Wekerle, H.2    Antel, J.3
  • 31
    • 15444370426 scopus 로고    scopus 로고
    • Impaired postthymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats
    • Poussier P, Ning T, Murphy T, Dabrowski D, Ramanathan S. Impaired postthymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. J Immunol 2005; 174: 4081-9.
    • (2005) J Immunol , vol.174 , pp. 4081-4089
    • Poussier, P.1    Ning, T.2    Murphy, T.3    Dabrowski, D.4    Ramanathan, S.5
  • 32
    • 33645885041 scopus 로고    scopus 로고
    • EAE: Pitfalls outweigh virtues of screening potential treatments for multiple sclerosis
    • Ransohoff RM. EAE: pitfalls outweigh virtues of screening potential treatments for multiple sclerosis. Trends Immunol 2006; 27: 167-8.
    • (2006) Trends Immunol , vol.27 , pp. 167-168
    • Ransohoff, R.M.1
  • 33
    • 0032419459 scopus 로고    scopus 로고
    • Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE
    • Renno T, Taupin V, Bourbonniere L, Verge G, Tran E, De Simone R, et al. Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE. Mol Cell Neurosci 1998; 12: 376-89.
    • (1998) Mol Cell Neurosci , vol.12 , pp. 376-389
    • Renno, T.1    Taupin, V.2    Bourbonniere, L.3    Verge, G.4    Tran, E.5    De Simone, R.6
  • 34
    • 0345422709 scopus 로고    scopus 로고
    • Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo
    • Rodriguez-Palmero M, Hara T, Thumbs A, Hünig T. Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo. Eur J Immunol 1999; 29: 3914-24.
    • (1999) Eur J Immunol , vol.29 , pp. 3914-3924
    • Rodriguez-Palmero, M.1    Hara, T.2    Thumbs, A.3    Hünig, T.4
  • 36
    • 4344657757 scopus 로고    scopus 로고
    • CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression and tissue invasion
    • Sarween N, Chodos A, Raykundalia C, Khan M, Abbas AK, Walker LS. CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression and tissue invasion. J Immunol 2004; 173: 2942-51.
    • (2004) J Immunol , vol.173 , pp. 2942-2951
    • Sarween, N.1    Chodos, A.2    Raykundalia, C.3    Khan, M.4    Abbas, A.K.5    Walker, L.S.6
  • 37
    • 0038643708 scopus 로고    scopus 로고
    • Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies
    • Schmidt J, Elflein K, Stienekemeier M, Rodriguez-Palmero M, Schneider C, Toyka KV, et al. Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies. J Neuroimmunol 2003a; 140: 143-52.
    • (2003) J Neuroimmunol , vol.140 , pp. 143-152
    • Schmidt, J.1    Elflein, K.2    Stienekemeier, M.3    Rodriguez-Palmero, M.4    Schneider, C.5    Toyka, K.V.6
  • 38
    • 0043268760 scopus 로고    scopus 로고
    • Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis
    • Schmidt J, Metselaar JM, Wauben MH, Toyka KV, Storm G, Gold R. Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis. Brain 2003b; 126: 1895-904.
    • (2003) Brain , vol.126 , pp. 1895-1904
    • Schmidt, J.1    Metselaar, J.M.2    Wauben, M.H.3    Toyka, K.V.4    Storm, G.5    Gold, R.6
  • 39
    • 0033559346 scopus 로고    scopus 로고
    • Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
    • Sorensen TL, Tani M, Jensen J, Pierce V, Lucchinetti C, Folcik VA, et al. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 1999; 103: 807-15.
    • (1999) J Clin Invest , vol.103 , pp. 807-815
    • Sorensen, T.L.1    Tani, M.2    Jensen, J.3    Pierce, V.4    Lucchinetti, C.5    Folcik, V.A.6
  • 40
    • 0036275625 scopus 로고    scopus 로고
    • Multiple sclerosis: A study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system
    • Sorensen TL, Trebst C, Kivisakk P, Klaege KL, Majmudar A, Ravid R, et al. Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. J Neuroimmunol 2002; 127: 59-68.
    • (2002) J Neuroimmunol , vol.127 , pp. 59-68
    • Sorensen, T.L.1    Trebst, C.2    Kivisakk, P.3    Klaege, K.L.4    Majmudar, A.5    Ravid, R.6
  • 41
    • 0035707638 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in the rat: Lessons in T-cell immunology and autoreactivity
    • Swanborg RH. Experimental autoimmune encephalomyelitis in the rat: lessons in T-cell immunology and autoreactivity. Immunol Rev 2001; 184: 129-35.
    • (2001) Immunol Rev , vol.184 , pp. 129-135
    • Swanborg, R.H.1
  • 42
    • 0031034123 scopus 로고    scopus 로고
    • CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28
    • Tacke M, Hanke G, Hanke T, Hünig T. CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur J Immunol 1997; 27: 239-47.
    • (1997) Eur J Immunol , vol.27 , pp. 239-247
    • Tacke, M.1    Hanke, G.2    Hanke, T.3    Hünig, T.4
  • 44
    • 3142723251 scopus 로고    scopus 로고
    • Lentivirally generated eGFP-transgenic rats allow efficient cell tracking in vivo
    • van den Brandt J, Wang D, Kwon SH, Heinkelein M, Reichardt HM. Lentivirally generated eGFP-transgenic rats allow efficient cell tracking in vivo. Genesis 2004b; 39: 94-9.
    • (2004) Genesis , vol.39 , pp. 94-99
    • Van Den Brandt, J.1    Wang, D.2    Kwon, S.H.3    Heinkelein, M.4    Reichardt, H.M.5
  • 45
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199: 971-9.
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 46
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 2005; 6: 338-44.
    • (2005) Nat Immunol , vol.6 , pp. 338-344
    • Von Boehmer, H.1
  • 47
    • 22644437303 scopus 로고    scopus 로고
    • CD4+CD25+-regulatory T cells from mouse to man
    • Wing K, Suri-Payer E, Rudin A. CD4+CD25+-regulatory T cells from mouse to man. Scand J Immunol 2005; 62: 1-15.
    • (2005) Scand J Immunol , vol.62 , pp. 1-15
    • Wing, K.1    Suri-Payer, E.2    Rudin, A.3
  • 48
    • 0038341894 scopus 로고    scopus 로고
    • Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation
    • Xie JH, Nomura N, Lu M, Chen SL, Koch GE, Weng Y, et al. Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation. J Leukoc Biol 2003; 73: 771-80.
    • (2003) J Leukoc Biol , vol.73 , pp. 771-780
    • Xie, J.H.1    Nomura, N.2    Lu, M.3    Chen, S.L.4    Koch, G.E.5    Weng, Y.6
  • 49
    • 0035421324 scopus 로고    scopus 로고
    • Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE)
    • Yura M, Takahashi I, Serada M, Koshio T, Nakagami K, Yuki Y, et al. Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). J Autoimmun 2001; 17: 17-25.
    • (2001) J Autoimmun , vol.17 , pp. 17-25
    • Yura, M.1    Takahashi, I.2    Serada, M.3    Koshio, T.4    Nakagami, K.5    Yuki, Y.6
  • 50
    • 0029019590 scopus 로고
    • Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat
    • Zettl UK, Gold R, Toyka KV, Hartung HP. Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat. J Neuropathol Exp Neurol 1995; 54: 540-7.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 540-547
    • Zettl, U.K.1    Gold, R.2    Toyka, K.V.3    Hartung, H.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.