SCOPUS 정보 검색 플랫폼

Volumn 9, Issue 5, 2014, Pages 940-952

In silico design, synthesis, and screening of novel deoxyhypusine synthase inhibitors targeting HIV-1 replication

(8) Schroeder, Marcus a Kolodzik, Adrian a Pfaff, Katharina a Priyadarshini, Poornima b Krepstakies, Marcel b Hauber, Joachim b Rarey, Matthias a Meier, Chris a

a UNIVERSITY OF HAMBURG (Germany)

b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY (Germany)

Author keywords

antiviral agents; drug design; enzymes; HIV; inhibitors

Indexed keywords

ANTIVIRUS AGENT; DEOXYHYPUSINE SYNTHASE; DEOXYHYPUSINE SYNTHASE INHIBITOR; ENZYME INHIBITOR; HYPUSINE; INITIATION FACTOR 5A; N 1 GUANYL 1,7 DIAMINOHEPTANE; UNCLASSIFIED DRUG; OXIDOREDUCTASE;

ARTICLE; BINDING AFFINITY; CELL CULTURE; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DOSE RESPONSE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CELLS, CULTURED; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84899941090 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300481 Document Type: Article

Times cited : (10)

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