Improved syntheses of 5′- S -(2-Aminoethyl)-6- N -(4-nitrobenzyl)- 5′-thioadenosine (SAENTA), analogues, and fluorescent probe conjugates: Analysis of cell-surface human equilibrative nucleoside transporter 1 (hENT1) levels for prediction of the antitumor efficacy of gemcitabine

Journal of Medicinal Chemistry

Volumn 53, Issue 16, 2010, Pages 6040-6053

  Robins, Morris J ^a   Peng, Yunshan ^a   Damaraju, Vijaya L ^b   Mowles, Delores ^b   Barron, Geraldine ^b   Tackaberry, Tracey ^b   Young, James D ^b   Cass, Carol E ^b  

^a Brigham Young University   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5' (2 AMINOETHYL) 6 N (4 NITROBENZYL) 5' THIOADENOSINE; 5' [2 (6 AMINOHEXANAMIDO)]ETHYL 6 N (4 NITROBENZYL) 5' THIOADENOSINE; ADENOSINE DERIVATIVE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; FLUORIDE; GEMCITABINE; PURINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONCENTRATION (PARAMETERS); CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION SYSTEM; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; NUCLEOSIDE TRANSPORT; SYNTHESIS;

ADENOSINE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DEOXYCYTIDINE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HUMANS; MICE; OOCYTES; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOINOSINE; THIONUCLEOSIDES; XENOPUS; YEASTS;

EID: 77955866444     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100432w     Document Type: Article

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