Synthesis and structural optimization of multiple H-bonding region of diarylalkyl (thio)amides as novel TRPV1 antagonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 24, 2009, Pages 8149-8160

  Li, Fu Nan ^a   Kim, Nam Jung ^a   Chang, Dong Jo ^a   Jang, Jaebong ^a   Jang, Hannah ^a   Jung, Jong Wha ^a   Min, Kyung Hoon ^b   Jeong, Yeon Su ^c   Kim, Sun Young ^c   Park, Young Ho ^c   Kim, Hee Doo ^d   Park, Hyeung Geun ^a   Suh, Young Ger ^a  

^a Seoul National University   (South Korea)

^b Chung Ang University   (South Korea)

^c AmorePacific Corporation   (South Korea)

^d Sookmyung Women's University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 3 (4 TERT BUTYLPHENYL) N [3 FLUORO 4 (METHYLSULFONAMIDO) 5 VINYLBENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [2 CHLORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [2 CHLORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANETHIOAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 (METHYLSULFONAMIDO) 4 (TRIFLUOROMETHYL)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 ACETYLENE 5 FLUORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 CHLORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 CHLORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANETHIOAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 CHLORO 5 METHYL 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 CYANO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 CYANO 5 FLUORO 4 (METHYLSULFONAMIDO) 5 VINYLBENZYL]PROPANETHIOAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 CYANO 5 FLUORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 CYCLOPROPYL 5 FLUORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 ETHYL 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 FLUORO 4 (METHYLSULFONAMIDO) 5 VINYLBENZYL]PROPANETHIOAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 FLUORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 FLUORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANETHIOAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 IODO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [3 IODO 4 (METHYLSULFONAMIDO)BENZYL]PROPANETHIOAMIDE; 3 (4 TERT BUTYLPHENYL) N [3,5 DIMETHYL 4 (METHYLSULFONAMIDO)ENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [4 (METHYLSULFONAMIDO) 2 (TRIFLUOROMETHYL)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [4 (METHYLSULFONAMIDO) 2 (TRIFLUOROMETHYL)BENZYL]PROPANETHIOAMIDE; 3 (4 TERT BUTYLPHENYL) N [4 (METHYLSULFONAMIDO) 3 (TRIFLUOROMETHYL)BENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [4 (METHYLSULFONAMIDO) 3 NITROBENZYL]PROPANAMIDE; 3 (4 TERT BUTYLPHENYL) N [4 (METHYLSULFONAMIDO) 3 VINYLBENZYL]PROPANAMIDE; ANALGESIC AGENT; CALCIUM 45; METHYL 5 [[3 (4 TERT BUTYLPHENYL)PROPANAMIDO]METHYL] 2 (METHYLSULFONAMIDO)BENZOATE; THIOAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BINDING SITES; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

RATTUS;

EID: 71849103872     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.043     Document Type: Article

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