Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 8, 1996, Pages 1664-1675

  Boden, Phil ^a   Eden, Jon M ^a   Hodgson, Julie ^a   Horwell, David C ^a   Hughes, John ^a   McKnight, Alexander T ^a   Lewthwaite, Russell A ^a   Pritchard, Martyn C ^a   Raphy, Jenny ^a   Meecham, Ken ^a   Ratcliffe, Giles S ^a   Suman Chauhan, Nirmala ^a   Woodruff, Geoffrey N ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

[1 [[1 METHYL 2 PHENYL 1 [(7 UREIDOHEPTYL)CARBAMOYL]ETHYL]CARBAMOYL] 2 PHENYLETHYL]CARBAMIC ACID TERT BUTYL ESTER; [2 (2,3 DIFLUOROPHENYL) 1 METHYL 1 [(7 UREIDOHEPTYL)CARBAMOYL]ETHYL]CARBAMIC ACID 2 METHYL 1 PHENYLPROPYL ESTER; DIPEPTIDE; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR ANTAGONIST; PD 157672; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANALGESIA; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CHO CELL; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; MOLECULAR CLONING; NONHUMAN; PARKINSON DISEASE; RECEPTOR AFFINITY; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; DIPEPTIDES; GUINEA PIGS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTOIDS; RECEPTORS, NEUROKININ-3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15844384484     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950892r     Document Type: Article

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